Skip to main content
SpringerLink
Log in

Hair Diseases (Alopecia Areata and Androgenetic Alopecia)

  • Chapter
Therapy of Skin Diseases

  • 1523 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Gilhar A, Ullmann Y, Berkutzki T et al (1998) Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 101:62–67

    Article  PubMed  CAS  Google Scholar 

  2. Gilhar A, Landau M, Assy B et al (2001) (2001) Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice. J Invest Dermatol 117:1357–1362

    Article  PubMed  CAS  Google Scholar 

  3. Colombe BW, Lou CD, Price VH (1999) The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. J Investig Dermatol Symp Proc 4:216–219

    Article  PubMed  CAS  Google Scholar 

  4. MacDonald Hull SP, Wood ML, Hutchinson PE et al (2003) Guidelines for the management of alopecia areata. Br J Dermatol 149:692–699

    Article  PubMed  CAS  Google Scholar 

  5. Madani S, Shapiro J (2000) Alopecia areata update. J Am Acad Dermatol 42:549–566

    PubMed  CAS  Google Scholar 

  6. Paus R, NickoloffBJ, Ito T (2005) A ‘hairy’ privilege. Trends Immunol 26:32–40

    Article  PubMed  CAS  Google Scholar 

  7. McElwee KJ, Boggess D, King LE Jr et al (1998) Experimental induction of alopecia areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts. J Invest Dermatol 111:797–803

    Article  PubMed  CAS  Google Scholar 

  8. McElwee KJ, Freyschmidt-Paul P, Hoffmann R et al (2005) Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(−) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/ HeJ mouse model. J Invest Dermatol 124:947–957

    Article  PubMed  CAS  Google Scholar 

  9. Sundberg JP, Boggess D, Silva KA et al (2003) Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice. J Invest Dermatol 120:771–775

    Article  PubMed  CAS  Google Scholar 

  10. Safavi KH, Muller SA, Suman VJ et al (1995) Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc 70:628–633

    Article  PubMed  CAS  Google Scholar 

  11. Goh C, Finkel M, Christos PJ et al (2006) Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol 20:1055–1060

    Article  PubMed  CAS  Google Scholar 

  12. Olsen E, Hordinsky M, McDonald-Hull S et al (1999) Alopecia areata investigational assessment guidelines. National Alopecia Areata Foundation. J Am Acad Dermatol 40:242–246

    Article  PubMed  CAS  Google Scholar 

  13. Tosti A, Iorizzo M, Botta GL et al (2006) Efficacy and safety of a new clobetasol propionate 0.05% foam in alopecia areata: a randomized, double-blind placebo-controlled trial. J Eur Acad Dermatol Venereol 20:1243–1247

    Article  PubMed  Google Scholar 

  14. Olsen EA, Carson SC, Turney EA (1992) Systemic steroids with or without 2% topical minoxidil in the treatment of alopecia areata. Arch Dermatol 128:1467–1473

    Article  PubMed  CAS  Google Scholar 

  15. Happle R, Hausen BM, Wiesner-Menzel L (1983) Diphencyprone in the treatment of alopecia areata. Acta Derm Venereol (Stockh) 63:49–52

    CAS  Google Scholar 

  16. Rokhsar CK, Shupack JL, Vafai JJ et al (1998) Efficacy of topical sensitizers in the treatment of alopecia areata. J Am Acad Dermatol 39:751–761

    Article  PubMed  CAS  Google Scholar 

  17. Yoshino T, Asada H, Ando Y et al (2001) Impaired responses of peripheral blood mononuclear cells to T-cell stimulants in alopecia areata patients with a poor response to topical immunotherapy. Br J Dermatol 145:415–421

    Article  PubMed  CAS  Google Scholar 

  18. Wiseman MC, Shapiro J, MacDonald N et al (2001) Predictive model for immunotherapy of alopecia areata with diphencyprone. Arch Dermatol 137:1063–1068

    PubMed  CAS  Google Scholar 

  19. Tosti A, Guidetti MS, Bardazzi F et al (1996) Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis. J Am Acad Dermatol 35:199–201

    Article  PubMed  CAS  Google Scholar 

  20. Buhl AE (1991) Minoxidil's action in hair follicles. J Invest Dermatol 96 (suppl):735–745

    Article  Google Scholar 

  21. Fiedler-Weiss VC (1987) Topical minoxidil solution (1% and 5%) in the treatment of alopecia areata. J Am Acad Dermatol 16:745–748

    Article  PubMed  CAS  Google Scholar 

  22. Price VH (1987) Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata. J Am Acad Dermatol 16:730–736

    Article  PubMed  CAS  Google Scholar 

  23. Fiedler-Weiss VC, Buys CM (1987) Evaluation of anthralin in the treatment of alopecia areata. Arch Dermatol 123:1491–1493

    Article  PubMed  CAS  Google Scholar 

  24. Nelson DA, Spielvogel RL (1985) Anthralin therapy for alopecia areata. Int J Dermatol 24:606–607

    PubMed  CAS  Google Scholar 

  25. Claudy AL, Gagnaire D (1983) PUVA treatment of alopecia areata. Arch Dermatol 119:975–978

    Article  PubMed  CAS  Google Scholar 

  26. Mitchell AJ, Douglass MC (1985) Topical photochemother-apy for alopecia areata. J Am Acad Dermatol 12:644–649

    Article  PubMed  CAS  Google Scholar 

  27. van der Schaar WW, Sillevis SJ (1984) An evaluation of PUVA-therapy for alopecia areata. Dermatologica 168:250–252

    Article  PubMed  Google Scholar 

  28. Friedli A, Labarthe MP, Engelhardt E et al (1998) Pulse methylprednisolone therapy for severe alopecia areata: an open prospective study of 45 patients. J Am Acad Dermatol 39:597–602

    Article  PubMed  CAS  Google Scholar 

  29. Kar BR, Handa S, Dogra S et al (2005) Placebo-controlled oral pulse prednisolone therapy in alopecia areata. J Am Acad Dermatol 52:287–290

    Article  PubMed  Google Scholar 

  30. Nakajima T, Inui S, Itami S (2007) Pulse corticosteroid therapy for alopecia areata: study of 139 patients. Dermatology. 215:320–324

    Article  PubMed  CAS  Google Scholar 

  31. Gupta A, Ellis C, Cooper K et al (1990) Oral cyclosporine for the treatmentof alopecia areata: a clinical and immuno-histochemical analysis. J Am Acad Dermatol 22:242–250

    Article  PubMed  CAS  Google Scholar 

  32. Shapiro J, Lui H, Tron V et al (1997) Systemic cyclosporine and low-dose prednisone in the treatment of chronic severe alopecia areata: a clinical and immunopathologic evaluation. J Am Acad Dermatol 36:114–117

    Article  PubMed  CAS  Google Scholar 

  33. Hay IC, Jamieson M, Ormerod AD (1998) Randomized trial of aromatherapy. Successful treatment for alopecia areata. Arch Dermatol 134:1349–1352

    CAS  Google Scholar 

  34. Ettefagh L, Nedorost S, Mirmirani P (2004) Alopecia areata in a patient using infliximab: new insights into the role of tumor necrosis factor on human hair follicles. Arch Dermatol 140:1012

    Article  PubMed  Google Scholar 

  35. Posten W, Swan J (2005) Recurrence of alopecia areata in a patient receiving etanercept injections. Arch Dermatol 141:759–760

    Article  PubMed  Google Scholar 

  36. Strober BE, Siu K, Alexis AF et al (2005) Etanercept does not effectively treat moderate to severe alopecia areata: an open-label study. J AmAcad Dermatol 52:159–163

    Article  Google Scholar 

  37. Heffernan MP, Hurley M Y, Martin KS et al (2005) Alefacept for alopecia areata. Arch Dermatol 141:1513–1516

    Article  PubMed  Google Scholar 

  38. Kaelin U, Hassan AS, Braathen LR et al (2006) Treatment of alopecia areata partim universalis with efalizumab. J Am Acad Dermatol 55:529–532

    Article  PubMed  Google Scholar 

  39. Carnahan MC, Goldstein DA (2000) Ocular complications of topical, peri-ocular, and systemic corticosteroids. Curr Opin Ophthalmol 11:478–483

    Article  PubMed  CAS  Google Scholar 

  40. Alam M, Gross EA, Savin RC (1999) Severe urticarial reaction to diphenylcyclopropenonetherapy for alopecia areata. J Am Acad Dermatol 40:110–112

    Article  PubMed  CAS  Google Scholar 

  41. MacDonald Hull SP, Norris JF, Cotterill JA (1989) Vitiligo following sensitisation with diphencyprone. Br J Dermatol 120:323

    Article  PubMed  CAS  Google Scholar 

  42. Gip L, Lodin A, Molin L (1969) Alopecia areata. A follow-up investigation of outpatient material. Acta Derm Venereol (Stockh) 49:180–188

    CAS  Google Scholar 

  43. Walker SA, Rothman S (1950) Alopecia areata: a statistical study and consideration of endocrine influences. J Invest Dermatol 14:403–413

    PubMed  CAS  Google Scholar 

  44. Weise K, Kretzschmar L, Jonh SM et al (1996) Topical immunotherapy in alopecia areata: anamnestic and clinical criteria of prognostic significance. Dermatology 192:129–133

    Article  PubMed  CAS  Google Scholar 

  45. De Waard-van der Spek FB, Oranje AP, De Raeymaecker DM et al (1989) Juvenile versus maturity-onset alopecia areata — a comparative retrospective clinical study. Clin Exp Dermatol 14:429–433

    Article  PubMed  Google Scholar 

  46. Muller SA, Winkelmann RK (1963) Alopecia areata. Arch Dermatol 88:290–297

    Article  PubMed  CAS  Google Scholar 

  47. Tosti A, Bellavista S, Iorizzo M (2006) Alopecia areata: a long term follow-up study of 191 patients. J Am Acad Dermatol 55:438–441

    Article  PubMed  Google Scholar 

  48. Hamilton JB (1942) Male hormone stimulation is a prerequisite and an incitant in common baldness. Am J Anatomy 71:451–480

    Article  Google Scholar 

  49. Randall VA, Hibberts NA, Thornton MJ et al (2000) The hair follicle: a paradoxical androgen target organ. Horm Res 54:243–250

    Article  PubMed  CAS  Google Scholar 

  50. Hamada K, Thornton MJ, Laing I et al (1996) The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles concurs with hair growth in 5 α-reductase deficiency. J Invest Dermatol 106:1017–1022

    Article  PubMed  CAS  Google Scholar 

  51. Hibberts NA, Howell AE, Randall VA (1998) Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp. J Endocrinol 156:59–65

    Article  PubMed  CAS  Google Scholar 

  52. Itami S, Kurata S, Sonoda T et al (1995) Interaction between dermal papilla cells and follicular epithelial cells in vitro. Br J Dermatol 132:527–532

    PubMed  CAS  Google Scholar 

  53. Randall VA, Thornton MJ, Messenger AG (1992) Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp. J Endocrinol 133:141–147

    Article  PubMed  CAS  Google Scholar 

  54. Thornton MJ, Laing I, Hamada K et al (1993) Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells. Clin Endocrinol (Oxf) 39:633–639

    Article  CAS  Google Scholar 

  55. Foitzik K, Lindner G, Mueller-Roever S et al (2000) Control of murine hair follicle regression (catagen) by TGF-β 1 in vivo. FASEB J 14:752–760

    PubMed  CAS  Google Scholar 

  56. Inui S, Fukuzato Y, Nakajima T et al (2002) Androgen-inducible TGF- β 1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understand paradoxical effects of androgen on human hair growth. FASEB J 16:1967–1969

    PubMed  CAS  Google Scholar 

  57. Ludwig E (1977) Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol 97:247–254

    Article  PubMed  CAS  Google Scholar 

  58. Norwood OT (1975) Male pattern baldness: classification and incidence. South Med J 68:1359–1365

    Article  PubMed  CAS  Google Scholar 

  59. Ross EK, Shapiro J (2005) Management of hair loss. Dermatol Clin 23:227–243

    PubMed  Google Scholar 

  60. Gormley GJ, Stoner E, Rittmaster RS et al (1990) Effects of finasteride (MK-906), a 5 α -reductase inhibitor, on circulating androgens in male volunteers. J Clin Endocrinol Metab 70:1136–1141

    Article  PubMed  CAS  Google Scholar 

  61. Kawashima M, Mizoguchi M, Igarashi A et al (2006) Long term (3 years) efficucy and safety profiles of finasteride in Japanese men with AGA (androgenetic alopecia). Jpn J Clin Dermatol 60:521–530 (in Japanese)

    Google Scholar 

  62. Price VH (1999) Treatment of hair loss. N Engl J Med 341:964–973

    Article  PubMed  CAS  Google Scholar 

  63. Li M, Marubayashi A, Nakaya Y et al (2001) Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol 117:1594–1600

    Article  PubMed  CAS  Google Scholar 

  64. Adamopoulos DA, Karamertzanis M, Nicopoulou S et al (1997) Beneficial effect of spironolactone on androgenic alopecia. Clin Endocrinol (Oxf) 47:759–760

    Article  CAS  Google Scholar 

  65. Peereboom-Wynia JD, van der Willigen AH, van Joost T et al (1989) The effect of cyproterone acetate on hair roots and hair shaft diameter in androgenetic alopecia in females. Acta Derm Venereol 69:395–398

    PubMed  CAS  Google Scholar 

  66. Okuda S (1939) Clinical and experimental studies of transplantation of living hairs. Jpn J Dermatol Urol 46:135–138 (in Japanese)

    Google Scholar 

  67. Inui S, Itami S (2006) Reversal of androgenetic alopecia by topical ketoconazole: relevance of anti-androgenic activity. J Dermatol Sci. doi:10.1016/j.jdermsci.2006.08.011

    Google Scholar 

  68. Iorizzo M, Vincenzi C, Voudouris S et al (2006) Finasteride treatment of female pattern hair loss. Arch Dermatol 142:298–302

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, 2-2 (G5), Yamadaoka, Suita-shi, Osaka, 565-0871, Japan

    Satoshi Itami & Shigeki Inui

Authors
  1. Satoshi Itami
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shigeki Inui
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Satoshi Itami .

Editor information

Editors and Affiliations

  1. Universitätsklinikum Köln Klinik und Poliklinik für Dermatologie und Venerologie, Kerpener Str. 62, Köln, 50924, Germany

    Thomas Krieg

  2. Dept. Dermatology, Columbia University Medical Center, 12th Floor, Herbert Irving Pavilion 161 Fort Washington Ave, New York, NY, 10032, USA

    David R. Bickers

  3. Dept. Dermatology & Cutaneous Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Yoshiki Miyachi

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Itami, S., Inui, S. (2010). Hair Diseases (Alopecia Areata and Androgenetic Alopecia). In: Krieg, T., Bickers, D.R., Miyachi, Y. (eds) Therapy of Skin Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78814-0_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-78814-0_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78813-3

  • Online ISBN: 978-3-540-78814-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation