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Iron as a risk factor in neurological diseases

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Abstract

In this review the properties of iron in various human brain structures (e.g. Substantia nigra, globus pallidus, hippocampus) were analyzed to assess the possibility of initiation of oxidative stress leading to such diseases as Parkinson’s and Alzheimer’s disease, and progressive supranuclear palsy. Our own studies with the use of Mössbauer spectroscopy, electron microscopy and enzyme-linked immuno-absorbent assay (ELISA) were confronted with other methods used in other laboratories. Our results suggest that hippocampus is the most fragile for oxidative stress structure in human brain (the death of nervous cells in hippocampus leads to Alzheimer’s disease). Changes in iron metabolism were also found in substantia nigra (the death of nervous cells of this structure produces Parkinson’s disease) and in globus pallidus (neurodegeneration of this structure causes progressive supranuclear palsy).

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Authors and Affiliations

  1. Faculty of Physics, Warsaw University of Technology, Warsaw, Poland

    Jolanta Galazka-Friedman

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  1. Jolanta Galazka-Friedman
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Correspondence to Jolanta Galazka-Friedman .

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Editors and Affiliations

  1. Indian Institute of Technology Kanpur, Kanpur, India

    N. S. Gajbhiye

  2. University of Pune, Pune, India

    S. K. Date

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Galazka-Friedman, J. (2008). Iron as a risk factor in neurological diseases. In: Gajbhiye, N.S., Date, S.K. (eds) ICAME 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78697-9_5

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