Ischaemic and Inflammatory Biomarkers in Cardiovascular Disease

  • Gopinath Gnanasegaran
  • Gregory Shabo
  • John R. Buscombe


Despite major advances in diagnosis and management, coronary artery disease continues to be a major public health problem. Patients with chest pain represent a heterogeneous group with varying presentation or severity of coronary artery disease and cardiac risk. Early prognostic evaluation of future cardiovascular risk is necessary for the application of appropriate treatment and optimal management in patients with chest pain. The role of cardiac markers in the diagnosis and management of patients with chest pain or in patients with suspected acute coronary syndromes (ACS) have improved dramatically with major technological advances. Currently various serum markers such as creatine kinase (CK)-MB, lactate dehydrogenase (LDH), myoglobin and cardiac troponins T (cTnT) and I (cTnI) are readily available and used as plasma diagnostic markers of myocardial necrosis in acute myocardial infarction (AMI) [1–18] (Table 7.1).


Acute Coronary Syndrome Acute Myocardial Infarction Creatine Kinase Acute Myocardial Infarction Cardiac Troponin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Gopinath Gnanasegaran
    • 1
  • Gregory Shabo
    • 1
  • John R. Buscombe
    • 2
  1. 1.Department of Nuclear MedicineGuy’s & St. Thomas’ Hospital NHS Foundation TrustLondonUK
  2. 2.Department of Nuclear MedicineRoyal Free HospitalLondonUK

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