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Myocardial Perfusion Imaging for Risk Stratification in Suspected or Known Coronary Artery Disease: Current Status and Limitations

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Integrating Cardiology for Nuclear Medicine Physicians

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Abstract

Coronary artery disease (CAD) remains the leading cause of morbidity and mortality in the western world. Early detection and risk stratification of underlying (CHD) is a major step in clinical decision-making. As discussed in the other chapters, myocardial perfusion imaging (MPI) using thallium-201(Tl-201) or technetium- 99m (Tc-99m) sestamibi or tetrofosmin, is used in various clinical settings to provide invaluable information on myocardial perfusion, left ventricular volumes and left ventricular function, and prognosis. MPI has the ability to localize hemodynamically important coronary stenosis; thus yielding positive results by increasing demand myocardial ischemia during exercise or inducing inhomogeneous distribution of radiotracers during pharmacological stress testing with dipyridamole or adenosine [1].

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Author information

Authors and Affiliations

  1. The Brody School of Medicine, Department of Medicine, Section of Cardiology, East Carolina University, 28858-4354, Greenville, NC, USA

    Firas A. Ghanem & Assad Movahed

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  1. Firas A. Ghanem
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  2. Assad Movahed
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Editors and Affiliations

  1. The Brody School of Medicine, Department of Medicine, Section of Cardiology, East Carolina University, 600 Moye Blvd., 27858-4354, Greenville, NC, USA

    Assad Movahed

  2. Department of Nuclear Medicine, Guy’s & St Thomas’ Hospital NHS Foundation Trust, St. Thomas Street, SE1 9RT, London, UK

    Gopinath Gnanasegaran

  3. Department of Nuclear Medicine, Royal Free Hospital, Pond Street, NW3 2QG, London, UK

    John Buscombe  & Margaret Hall  & 

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Ghanem, F., Movahed, A. (2009). Myocardial Perfusion Imaging for Risk Stratification in Suspected or Known Coronary Artery Disease: Current Status and Limitations. In: Movahed, A., Gnanasegaran, G., Buscombe, J., Hall, M. (eds) Integrating Cardiology for Nuclear Medicine Physicians. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78674-0_20

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  • DOI: https://doi.org/10.1007/978-3-540-78674-0_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78673-3

  • Online ISBN: 978-3-540-78674-0

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