Advertisement

Fever in Non-infectious Diseases

  • #x203A; Fever is commonly found in children with haematological disorders, of which sickle cell anaemia is the most common.

  • › An important cause of febrile illnesses in children with haemolytic disorders is infection with human parvovirus B19 (HPV B19).

  • › Children with cancer are often neutropenic and any associated fever needs urgent medical attention because of possible underlying serious bacterial infections, which may be responsible for 50% of deaths

  • › Fever in children with cancer may be due either to the disease (neoplastic fever) or to infection. The diagnosis of neoplastic fever should only be considered after exclusion of infection.

  • › Early administration of antibiotics to children with febrile neutropenia prior to confirming the infection has improved the survival in these children.

  • › In rheumatology, children with juvenile idiopathic arthritis have the highest incidence of fever. Children may present with persistent fever of unknown origin and are often subjected to intensive investigations, including many trials of antibiotics and occasionally laparotomy.

  • › In Kawasaki disease, fever has diagnostic and prognostic importance: higher temperature during days 10-13 of the disease and its continuation for more than 14 days is a risk factor associated with coronary involvement.

  • › Fever following vaccination is common and usually trivial. It is not a contraindication to further doses of vaccines.

Keywords

Juvenile Idiopathic Arthritis Kawasaki Disease Familial Mediterranean Fever Rheumatic Fever Macrophage Activation Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

Haematology

  1. 1.
    Platt OS, Thorington BD, Brambilla DJ, et al. Pain in sickle cell disease: rates and risk factors. N Engl J Med 1991; 325: 11–16PubMedGoogle Scholar
  2. 2.
    Smith WK, Zhao H, Hodinka RL, et al. Epidemiology of human parvovirus B19 in children with sickle cell anaemia. Blood 2004; 103: 422–7CrossRefGoogle Scholar
  3. 3.
    Powars D, Overturf GD, Wilkins J. Commentary in sickle cell and SC disease. J Pediatr 1983; 103: 242–4PubMedCrossRefGoogle Scholar
  4. 4.
    McIntosh S, Rocks Y, Ritchey K, et al. Fever in young children with sickle cell disease. J Pediatr 1980; 96: 199–204PubMedCrossRefGoogle Scholar
  5. 5.
    Smith AW, Hendrichse RG, Harrison C, et al. Iron deficiency anaemia and its response to oral iron: report of a study in rural Gambian children treated at home by their mothers. Ann Trop Paediatr 1989; 9: 17–23PubMedGoogle Scholar
  6. 6.
    Gera T, Sachdev HPS. Effects of iron supplementation on incidence of infectious illness in children: systematic review. Br Med J 2002; 325: 1142–4.CrossRefGoogle Scholar
  7. 7.
    McKee LC. Fever in megaloblastic anaemia. South Med J 1979; 72: 1423–4PubMedGoogle Scholar
  8. 8.
    Igbal M P. Megaloblastic anaemia in a hospital-based population. Med Sci Res 2000; 28: 45–7Google Scholar
  9. 9.
    Welborn JL, Hersch J. Blood transfusion reactions: which are life-threatening and which are not? Postgrad Med 1991; 90: 125–38PubMedGoogle Scholar

Neoplastic Diseases

  1. 10.
    Sasse EC, Sasse AD, Bandalise SR, et al. Colony-stimulating factors for prevention of myelosuppressive therapy. Cochrane Libr 2006; no 4.Google Scholar
  2. 11.
    Lobell M, Boggs DR, Wintrope MM. The clinical significance of fever in Hodgkin’s disease. Arch Intern Med 1966; 117: 335–42Google Scholar

Rheumatic Diseases

  1. 12.
    Calabro JJ, Marchesano JM. Fever associated with juvenile rheumatoid arthritis. N Engl J Med 1967; 276: 11–18PubMedCrossRefGoogle Scholar
  2. 13.
    Tucker LB et al, Adult- and childhood-onset systemic lupus erythematosus: a comparison of onset, clinical features, serology, and outcome. Rheumatology 1995; 34: 866–872CrossRefGoogle Scholar
  3. 14.
    Love LA, Leff RL, Fraser DD, et al. A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore) 1991; 70: 360–74Google Scholar
  4. 15.
    Koran G, Lavi S, Rose V, et al. Kawasaki disease: review of risk factors for coronary aneurysms. J Pediatr 1986; 108: 388–92CrossRefGoogle Scholar
  5. 16.
    Salo E, Pelkonen P, Pettay O. Outbreak of Kawasaki disease in Finland. Acta Paediatr Scand 1986; 75: 75–80PubMedCrossRefGoogle Scholar

Fever after vaccination

  1. 17.
    Miller E. Overview of recent clinical trials of acellular pertussis vaccines. Biologicals 1999; 27: 79–86PubMedCrossRefGoogle Scholar
  2. 18.
    Tozzi AE, Olin P. Common side effects in the Italian and Stockholm I trials. Dev Biol Stand 1997; 89: 105–8PubMedGoogle Scholar

Sarcoidosis

  1. 19.
    Hoffman AL, Millman N, Byq KE. Childhood sarcoidosis in Denmark 1979–1994: incidence, clinical features and laboratory results at presentation in 48 children. Acta Pediatr Int Paediatr 2004; 93: 30–6Google Scholar
  2. 20.
    Pietinalho A, Ohmichi M, Hiraga Y, et al. The mode of presentation of sarcoidosis in Finland and in Hokkaido, Japan. Sarcoidosis Vasc Diffuse Lung Dis 1996; 13: 159–66PubMedGoogle Scholar
  3. 21.
    Nolan J P, Klatskin G. The fever of sarcoidosis. Ann Intern Med 1964; 61: 455–61PubMedGoogle Scholar

Familial Mediterranean Fever

  1. 22.
    McDermott MF. A common pathway in periodic fever syndromes. Trends Immunol 2004; 25: 457–60PubMedCrossRefGoogle Scholar
  2. 23.
    Zemer D, Pras M, Sohar E, et al. Colchicine in the prevention and treatment of the amyloidosis of FMF. N Engl J Med 1986; 314: 1001–5PubMedGoogle Scholar

Sweet Syndrome

  1. 24.
    Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol 1964; 76: 349–56PubMedCrossRefGoogle Scholar
  2. 25.
    Boatman B W, Talor RC, Klein LE, et al. Sweet's syndrome in children. South Med J 1994; 87: 193–6PubMedCrossRefGoogle Scholar

Familial Dysautonomia

  1. 26.
    Axelrod FB, Proges R F, Sein ME. Neonatal recognition of familial dysautonomia. J Pediatr 1987; 110: 946–8PubMedCrossRefGoogle Scholar
  2. 27.
    Tirosh I, Hoffer V, Finkelstein Y, et al. Heat stroke in familial dysautonomia. Pediatr Neurol 2003; 29: 164–66PubMedCrossRefGoogle Scholar

Fever associated with teething

  1. 28.
    Guthrie L. Teething. Br Med J 1998; 2: 486Google Scholar
  2. 29.
    Illingworth RS. The Normal Child, 3rd edn. Churchill, London. 1964, pp. 77–80Google Scholar
  3. 30.
    Jaber I, Cohen IJ, Mor A. Fever associated with teething. Arch Dis Child 1992; 67: 233–4PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Personalised recommendations