Abstract
Men value highly their reproductive health as part of a full life. Consequently its preservation is an essential consideration in medical care and dissatisfaction can be anticipated should the focus on the presenting disease and its treatment neglect the often unstated, but nevertheless deeply felt, men's expectations that they retain full reproductive functions.
Keywords
- Erectile Dysfunction
- Testosterone Level
- Familial Mediterranean Fever
- Testosterone Replacement Therapy
- Hypogonadotropic Hypogonadism
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Abbasi AA, Prasad AS, Ortega J, Congco E, Oberleas D (1976) Gonadal function abnormalities in sickle cell anemia. Studies in adult male patients. Ann Intern Med 85:601–605
Abs R, Verhelst J, Maeyaert J, Van Buyten JP, Opsomer F, Adriaensen H, Verlooy J, Van Havenbergh T, Smet M, Van Acker K (2000) Endocrine consequences of long-term intrathecal administration of opioids. J Clin Endocrinol Metab 85:2215–2222
Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G (2005) Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients. Brain 128:659–670
Agbaje IM, Rogers DA, McVicar CM, McClure N, Atkinson AB, Mallidis C, Lewis SE (2007) Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod 22:1871–1877
Agbaraji VO, Scott RB, Leto S, Kingslow LW (1988) Fertility studies in sickle cell disease: semen analysis in adult male patients. Int J Fertil 33:347–352
Agirregoitia E, Valdivia A, Carracedo A, Casis L, Gil J, Subiran N, Ochoa C, Irazusta J (2006) Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility. J Clin Endocrinol Metab 91:4969–4975
Akbari F, Alavi M, Esteghamati A, Mehrsai A, Djaladat H, Zohrevand R, Pourmand G (2003) Effect of renal transplantation on sperm quality and sex hormone levels. BJU Int 92:281–283
Akhondzadeh S, Rezaei F, Larijani B, Nejatisafa AA, Kashani L, Abbasi SH (2006) Correlation between testosterone, gonad-otropins and prolactin and severity of negative symptoms in male patients with chronic schizophrenia. Schizophr Res 84:405–410
Al-Ghazo MA, Bani-Hani KE, Amarin ZO (2005) Tuberculous epididymitis and fertility in North Jordan. Saudi Med J 26:1212–1215
Albaaj F, Sivalingham M, Haynes P, McKinnon G, Foley RN, Waldek S, O'Donoghue DJ, Kalra PA (2006) Prevalence of hypogonadism in male patients with renal failure. Postgrad Med J 82:693–696
AraujoAB, Kupelian V, Page ST, Handelsman DJ, BremnerWJ, McKinlay JB (2007) Sex steroids and all-cause and cause-specific mortality in men. Arch Intern Med 167:1252–1260
Arnon J, Meirow D, Lewis-Roness H, Ornoy A (2001) Genetic and teratogenic effects of cancer treatments on gametes and embryos. Hum Reprod Update 7:394–403
Atsuta N, Watanabe H, Ito M, Banno H, Suzuki K, Katsuno M, Tanaka F, Tamakoshi A, Sobue G (2006) Natural history of spinal and bulbar muscular atrophy (SBMA): a study of 223 Japanese patients. Brain 129:1446–1455
Bagatell CJ, BremnerWJ (1990) Sperm counts and reproductive hormones in male marathoners and lean controls. Fertil Steril 53:688–692
Ballal SH, Domoto DT, Polack DC, Marciulonis P, Martin KJ (1991) Androgens potentiate the effects of erythropoietin in the treatment of anemia of end-stage renal disease. Am J Kid Dis 17:29–33
Banerji A, Sloane DE, Sheffer AL (2008) Hereditary angioe-dema: a current state-of-the-art review, V: attenuated androgens for the treatment of hereditary angioedema. Ann Allergy Asthma Immunol 100:S19–22
Barrett-Connor E (1992) Lower endogenous androgen levels and dyslipidemia in men with non-insulin-dependent diabetes mellitus. Ann Intern Med 117:807–811
Bauer J, Stoffel-Wagner B, Flugel D, Kluge M, Schramm J, Bidlingmaier F, Elger CE (2000) Serum androgens return to normal after temporal lobe epilepsy surgery in men. Neurology 55:820–824
Bauer J, Blumenthal S, Reuber M, Stoffel-Wagner B (2004) Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy. Neurology 62:243–246
Ben-Chetrit E, Levy M (2003) Reproductive system in familial Mediterranean fever: an overview. Ann Rheum Dis 62:916–919
Berkovitz GD, Wilson DP, Carpenter NJ, Brown TR, Migeon CJ (1986) Gonadal function in men with the Martin-Bell (frag-ile-X) syndrome. Am J Med Genet 23:227–239
Bhasin S, Storer TW, Asbel-Sethi N, Kilbourne A, Hays R, Sinha-Hikim I, Shen R, Arver S, Beall G (1998) Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels. J Clin Endocrinol Metab 83:3155–3162
Bhasin S, Parker RA, Sattler F, Haubrich R, Alston B, Umbleja T, ShikumaCM (2007) Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity. J Clin Endocrinol Metab 92:1049–1057
Bokemeyer C, Schmoll HJ, van Rhee J, Kuczyk M, Schuppert F, Poliwoda H (1994) Long-term gonadal toxicity after therapy for Hodgkin's and non-Hodgkin's lymphoma. Ann Hematol 68:105–110
Bolumar F, Olsen J, Boldsen J (1996) Smoking reduces fecundity: a European multicenter study on infertility and subfe-cundity. The European Study Group on Infertility and Subfecundity. Am J Epidemiol 143:578–587
Bona G, Marinello D, Oderda G (2002) Mechanisms of abnormal puberty in coeliac disease. Horm Res 57(2):63–65
Bronspiegel-Weintrob N, Oliver NF, Tyler B, Andrews DF, Freedman MH, Holland FJ (1990) Effect of age at the start of iron chelation therapy on gonadal function in beta-thalas-semia major. N Engl J Med 323:713–719
Brown DJ, Hill ST, Baker HW (2006) Male fertility and sexual function after spinal cord injury. Prog Brain Res 152:427–439
Bullmann C, Faust M, Hoffmann A, Heppner C, Jockenhovel F, Muller-Wieland D, Krone W (2000) Five cases with central diabetes insipidus and hypogonadism as first presentation of neurosarcoidosis. Eur J Endocrinol 142:365–372
Buvat J, Lemaire A, Ardaens K, Buvat-Herbaut M, Racadot A (1983) Profile of gonadal hormones in 8 cases of male anorexia nervosa studied before and during weight gain. Ann Endocrinol 44:229–234
Cantu JM, Scaglia HE, Medina M, Gonzalez-Diddi M, Moranto T, Moreno ME, Perez-Palacios G (1976) Inherited congenital normofunctional testicular hyperplasia and mental deficiency. Hum Genet 33:23–33
Carani C, Isidori AM, Granata A, Carosa E, Maggi M, Lenzi A, Jannini EA (2005) Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J Clin Endocrinol Metab 90:6472–6479
Carlsen E, Andersson AM, Petersen JH, Skakkebaek NE (2003) History of febrile illness and variation in semen quality. Hum Reprod 18:2089–2092
Castilla-Cortazar I, Garcia M, Quiroga J, Diez N, Diez-Caballero F, Calvo A, Diaz M, Prieto J (2000) Insulin-like growth fac-tor-I reverts testicular atrophy in rats with advanced cirrhosis. Hepatology 31:592–600
Castilla-Cortazar I, Diez N, Garcia-Fernandez M, Puche JE, Diez-Caballero F, Quiroga J, Diaz-Sanchez M, Castilla A, Casares AD, Varela-Nieto I, Prieto J, Gonzalez-Baron S (2004) Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1. World J Gastroenterol 10:2529–2534
Chen RY, Wittert GA, Andrews GR (2006) Relative androgen deficiency in relation to obesity and metabolic status in older men. Diabetes Obes Metab 8:429–435
Chia SE, Lim ST, Tay SK, Lim ST (2000) Factors associated with male infertility: a case-control study of 218 infertile and 240 fertile men. Bjog 107:55–61
Chillon M, Casals T, Mercier B, Bassas L, Lissens W, Silber S, Romey MC, Ruiz-Romero J, Verlingue C, Claustres M, et al. (1995) Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens. N Engl J Med 332:1475–1480
Claahsen-van der Grinten HL, Otten BJ, Hermus AR, Sweep FC, Hulsbergen-van de Kaa CA (2008) Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage. Fertil Steril 89:597–601
Cosentino MJ, Chey WY, Takihara H, Cockett ATK (1984) The effects of sulphsalazine on human male fertility potential and seminal prostaglandins. J Urol 132:682–686
Crawford BA, Spaliviero JA, Simpson JM, Handelsman DJ (1998) Testing the gonadal regression-cytoprotection hypothesis. Cancer Res 58:5105–5109
Crawford BA, Liu PY, Kean MT, Bleasel JF, Handelsman DJ (2003) Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment. J Clin Endocrinol Metab 88:3167–3176
Crino A, Schiaffini R, Ciampalini P, Spera S, Beccaria L, Benzi F, Bosio L, Corrias A, Gargantini L, Salvatoni A, Tonini G, Trifiro G, Livieri C (2003) Hypogonadism and pubertal development in Prader-Willi syndrome. Eur J Pediatr 162:327–333
Crittenden JA, Handelsman DJ, Stewart GJ (1992) Semen analysis in human immunodeficiency virus infection. Fertil Steril 57:1294–1299
Cundy T, Butler J, Bomford A, Williams R (1993) Reversibility of hypogonadotrophic hypogonadism associated with genetic hemochromatosis. Clin Endocrinol 38:617–620
Cunningham KA, Beagley KW (2008) Male genital tract chla-mydial infection: implications for pathology and infertility. BiolReprod 79:180–189
Cutolo M, Balleari E, Giusti M, Intra E, Accardo S (1991) Androgen replacement therapy in male patients with rheumatoid arthritis. Arthr Rheum 34:1–5
daCunhaMF, Meistrich ML, Fuller LM, Cundiff JH, Hagemeister FB, Velasquez WS, McLaughlin P, Riggs SA, Cabanillas FF, Salvador PG (1984) Recovery of spermatogenesis after treatment for Hodgkins disease: limiting dose of MOPP chemotherapy. J Clin Oncol 2:571–577
Daniell HW, Lentz R, Mazer NA (2006) Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency. J Pain 7:200–210
Darnton SJ, Zgainski B, Grenier I, Allister K, Hiller L, McManus KG, Steyn RS (1999) The use of an anabolic steroid (nan-drolone decanoate) to improve nutritional status after esoph-ageal resection for carcinoma. Dis Esophagus 12:283–288
de la Balze FA, Arrillaga F, Mancini RE, Janches M, Davidson OW, Gurtman AI (1962) Male hypogonadism in hypothy-roidism: a study of six cases. J Clin Endocrinol Metab 22:212–222
de Paepe ME, Waxman M (1989) Testicular atrophy in AIDS: a study of 57 autopsy cases. Hum Pathol 20:210–214
Denzer C, Weibel A, Muche R, Karges B, Sorgo W, Wabitsch M (2007) Pubertal development in obese children and adolescents. Int J Obes 31:1509–1519
Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P (2004) Frequent occurrence of hypogonado-tropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab 89:5462–5468
Diamond T, Stiehl D, Posen S (1991) Effects of testosterone and venesection on spinal and peripheral bone mineral in six hypogonadal men with hemochromatosis. J Bone Min Res 6:39–43
Dimitrova D, Kalaydjiev S, Mendizova A, Piryova E, Nakov L (2005) Circulating antibodies to human spermatozoa in patients with ulcerative colitis. Fertil Steril 84:1533–1535
Dong Q, Hawker F, McWilliam D, Bangah M, Burger H, Handelsman DJ (1992) Circulating inhibin and testosterone levels in men with critical illness. Clin Endocrinol 36:399–404
Doumouchtsis KK, Kostakis AI, Doumouchtsis SK, Grapsa EI, Passalidou IA, Tziamalis MP, Poulakou MV, Vlachos IS, Perrea DN (2008) The effect of sexual hormone abnormalities on proximal femur bone mineral density in hemodialysis patients and the possible role of RANKL. Hemodial Int 12:100–107
Dube MP, Parker RA, Mulligan K, Tebas P, Robbins GK, Roubenoff R, Grinspoon SK (2007) Effects of potent antiret-roviral therapy on free testosterone levels and fat-free mass in men in a prospective, randomized trial: A5005s, a sub-study of AIDS Clinical Trials Group Study 384. Clin Infect Dis 45:120–126
Dunkel L, Raivio T, Laine J, Holmberg C (1997) Circulating luteinizing hormone receptor inhibitor(s) in boys with chronic renal failure. Kid Int 51:777–784
Dunsmuir WD, Holmes SA (1996) The aetiology and management of erectile, ejaculatory, and fertility problems in men with diabetes mellitus. Diabet Med 13:700–708
Eiam-Ong S, Buranaosot S, Eiam-Ong S, Wathanavaha A, Pansin P (2007) Nutritional effect of nandrolone decanoate in predialysis patients with chronic kidney disease. J Ren Nutr 17:173–178
Eiholzer U, l'Allemand D, Rousson V, Schlumpf M, Gasser T, Girard J, Gruters A, Simoni M (2006) Hypothalamic and gonadal components of hypogonadism in boys with Prader-Labhart-Willi syndrome. J Clin Endocrinol Metab 91:892–898
Emanuele MA, Emanuele N (2001) Alcohol and the male reproductive system. Alcohol Res Health 25:282–287
English KM, Steeds RP, Jones TH, Diver MJ, Channer KS (2000) Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation 102:1906–1911
Esfahani AF, Eftekhari M, Zenooz N, Saghari M (2004) Gonadal function in patients with differentiated thyroid cancer treated with (131)I. Hell J Nucl Med 7:52–55
Falus A, Feher KG, Walcz E, Brozik M, Fust G, Hidvegi T, Feher T, Meretey K (1990) Hormonal regulation of complement biosynthesis in human cell lines -I. Androgens and gamma-interferon stimulate the biosynthesis and gene expression of C1 inhibitor in human cell lines U937 and HepG2. Mol Immunol 27:191–195
Farthing MJR, Dawson AM (1983) Impaired semen quality in Crohn's disease - drugs, ill health, or undernutrition? Scand J Gastroenterol 18:57–60
Fenwick PB, Toone BK, Wheeler MJ, Nanjee MN, Grant R, Brown D (1985) Sexual behaviour in a centre for epilepsy. Acta Neurol Scand 71:428–435
Francis RB, Kasper CK (1983) Reproduction in hemophilia. JAMA 250:3192–3195
Frank MM (2008) 8. Hereditary angioedema. J Allergy Clin Immunol 121:S398–401; quiz S419
Frias J, Torres JM, Miranda MT, Ruiz E, Ortega E (2002) Effects of acute alcohol intoxication on pituitary-gonadal axis hormones, pituitary-adrenal axis hormones, beta-endorphin and prolactin in human adults of both sexes. Alcohol 37:169–173
Garber KB, Visootsak J, Warren ST (2008) Fragile X syndrome. Eur J Hum Genet 16:666–672
Garcia JM, Li H, Mann D, Epner D, Hayes TG, Marcelli M, Cunningham GR (2006) Hypogonadism in male patients with cancer. Cancer 106:2583–2591
Genesca A, Miro R, Caballin MR, Benet J, Germa JR, Egozcue J (1990) Sperm chromosome studies in individuals treated for testicular cancer. Hum Reprod 5:286–290
Gluud C, Bennett P, Dietrichson O, Johnsen SG, Ranek L, Svendsen LB, Juhl E (1981) Short-term parenteral and pero-ral testosterone administration in men with alcoholic cirrhosis. Scand J Gastroenterol 16:749–755
Gordon D, Beastall GH, Thomson JA, Sturrock RD (1986) Androgenic status and sexual function in males with rheumatoid arthritis and ankylosing spondylitis. Quart J Med 231:671–679
Gray A, Feldman HA, McKinlay JB, Longcope C (1991) Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 73:1016–1025
Greenfield DM, Walters SJ, Coleman RE, Hancock BW, Eastell R, Davies HA, Snowden JA, Derogatis L, Shalet SM, Ross RJ (2007) Prevalence and consequences of androgen deficiency in young male cancer survivors in a controlled cross-sectional study. J Clin Endocrinol Metab 92:3476–3482
Griggs RC, Pandya S, Florence JM, Brooke MH, Kingston W, Miller JP, Chutkow J, Herr BE, Moxley RT (1989) Randomized controlled trial of testosterone in myotonic dystrophy. Neurology 39:219–222
Grinspoon S, Corcoran C, Lee K, Burrows B, Hubbard J, Katznelson L, Walsh M, Guccione A, Cannan J, Heller H, Basgoz N, Klibanski A (1996) Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting. J Clin Endocrinol Metab 81:4051–4058
Grinspoon S, Corcoran C, Askari H, Schoenfeld D, Wolf L, Burrows B, Walsh M, Hayden D, Parlman K, Anderson E, Basgoz N, Klibanski A (1998) Effects of androgen administration in men with the AIDS wasting syndrome. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 129:18–26
Grossmann M, Thomas MC, Panagiotopoulos S, Sharpe K, Macisaac RJ, Clarke S, Zajac JD, Jerums G (2008) Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab 93:1834–1840
Grunnert E, Nyfors A, Hansen KB (1977) Studies on human semen in topical corticosteroid-treated and in methotrexate-treated psoriatics. Dermatologica 154:78–84
Grunstein RR, Handelsman DJ, Lawrence SJ, Blackwell C, Caterson ID, Sullivan CE (1989) Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy. J Clin Endocrinol Metab 68:352–358
Haimov-Kochman R, Ben-Chetrit E (1998) The effect of colchi-cine treatment on sperm production and function: a review. Hum Reprod 13:360–362
Hall GM, Larbre JP, Spector TD, Perry LA, Da Silva JA (1996) A randomized trial of testosterone therapy in males with rheumatoid arthritis. Br J Rheumatol 35:568–573
Handelsman DJ (1985) Hypothalamic-pituitary gonadal dysfunction in chronic renal failure, dialysis, and renal transplantation. Endocr Rev 6:151–182
Handelsman DJ, Dong Q (1992) Ontogenic regression: a model of stress and reproduction. In: Sheppard K, Boublik JH, Funder JW (eds) Stress and reproduction, vol 86. Raven Press, New York, pp 333–345
Handelsman DJ, Dong Q (1993) Hypothalamo-pituitary gonadal axis in chronic renal failure. Endocrinol Metab Clin North Am 22:145–161
Handelsman DJ, Staraj S (1985) Testicular size: the effects of aging, malnutrition, and illness. J Androl 6:144–151
Handelsman DJ, Turtle JR (1983) Testicular damage after radioactive iodine (I-131) therapy for thyroid cancer. Clin Endocrinol 18:465–472
Handelsman DJ, Yue DK, Turtle JR (1983) Hypogonadism and massive testicular infiltration due to amyloidosis. J Urol 129:610–612
Handelsman DJ, Conway AJ, Boylan LM, Turtle JR (1984) Young's syndrome. Obstructive azoospermia and chronic sinopulmonary infections. N Engl J Med 310:3–9
Handelsman DJ, Strasser S, McDonald JA, Conway AJ, McCaughan GW (1995) Hypothalamic-pituitary testicular function in end-stage non-alcoholic liver disease before and after liver transplantation. Clin Endocrinol 43:331–337
Herzog AG, Klein P, Jacobs AR (1998) Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism. Neurology 50:782–784
Hill M, Milan S, Cunningham D, Mansi J, Smith I, Catovsky D, Gore M, Zulian G, Selby P, Horwich A, et al. (1995) Evaluation of the efficacy of the VEEP regimen in adult Hodgkin's disease with assessment of gonadal and cardiac toxicity. J Clin Oncol 13:387–395
Howell SJ, Shalet SM (2005) Spermatogenesis after cancer treatment: damage and recovery. J Natl Cancer Inst Monogr 34:12–17
Howell SJ, Radford JA, Adams JE, Smets EM, Warburton R, Shalet SM (2001) Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy. Clin Endocrinol 55:315–324
Hubert D, Patrat C, Guibert J, Thiounn N, Bienvenu T, Viot G, Jouannet P, Epelboin S (2006) Results of assisted reproductive technique in men with cystic fibrosis. Hum Reprod 21:1232–1236
Hughes GS, Mathur RS, Margolius HS (1989) Sex steroid hormones are altered in essential hypertension. J Hypertens 7:181–187
Hviid A, Rubin S, Muhlemann K (2008) Mumps. Lancet 371:932–944
Hyer S, Vini L, O'Connell M, Pratt B, Harmer C (2002) Testicular dose and fertility in men following I(131) therapy for thyroid cancer. Clin Endocrinol 56:755–758
Inci K, Duzova A, Aki FT, Bilginer Y, Erkan I, Tasar C, Bakkaloglu A, Bakkaloglu M (2006) Semen variables and hormone profiles after kidney transplantation during adolescence. Transplant Proc 38:541–542
Isojarvi J (2008) Disorders of reproduction in patients with epilepsy: antiepileptic drug related mechanisms. Seizure 17:111–119
Jaaskelainen J, Kiekara O, Hippelainen M, Voutilainen R (2000) Pituitary gonadal axis and child rate in males with classical 21-hydroxylase deficiency. J Endocrinol Invest 23:23–27
tremor/ataxia syndrome in a premutation carrier population. JAMA 291:460–469
Jaffe A, Chen Y, Kisch ES, Fischel B, Alon M, Stern N (1996) Erectile dysfunction in hypertensive subjects. Assessment of potential determinants. Hypertension 28:859–862
Jaffe MD (1977) Effect of testosterone cypionate on postexer-cise ST segment depression. Br Heart J 39:1217–1222
Jensen TK, Hjollund NH, Henriksen TB, Scheike T, Kolstad H, Giwercman A, Ernst E, Bonde JP, Skakkebaek NE, Olsen J (1998) Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy. BMJ 317:505–510
Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH, Skakkebaek NE (2004) Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 82:863–870
Jin B, McCaughan GW, Handelsman DJ (1999) Effects of liver disease and transplantation on the human prostate. J Androl 20:559–565
Johansen KL, Mulligan K, Schambelan M (1999) Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial. JAMA 281:1275–1281
Jones RD, Hugh Jones T, Channer KS (2004) The influence of testosterone upon vascular reactivity. Eur J Endocrinol 151:29–37
Kalaydjiev S, Dimitrova D, Mitov I, Dikov I, Nakov L (2007) Serum sperm antibodies after diarrhoeal diseases. Andrologia 39:101–108
Kamischke A, Kemper DE, Castel MA, Luthke M, Rolf C, Behre HM, Magnussen H, Nieschlag E (1998) Testosterone levels in men with chronic obstructive pulmonary disease with or without glucocorticoid therapy. Eur Respir J 11:41–45
Kandeel FR, Swerdloff RS (1988) Role of temperature in regulation of spermatogenesis and the use of heating as a method for contraception. Fertil Steril 49:1–23
Kaneda Y, Fujii A (2000) Effects of chronic neuroleptic administration on the hypothalamo-pituitary-gonadal axis of male schizophrenics. Prog Neuropsychopharmacol Biol Psychiatry 24:251–258
Kapoor D, Goodwin E, Channer KS, Jones TH (2006) Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercho-lesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol 154:899–906
Karadag F, Ozcan H, Karul AB, Yilmaz M, Cildag O (2007) Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease. Int J Clin Pract [Epub]
Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G (2006) Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA). Exp Neurol 200:8–18
Kaymakoglu S, Okten A, Cakaloglu Y, Boztas G, Besisik F, Tascioglu C, Yalcin S (1995) Hypogonadism is not related to the etiology of liver cirrhosis. J Gastroenterol 30:745–750
Kelleher S, Wishart SM, Liu PY, Turner L, Di Pierro I, Conway AJ, Handelsman DJ (2001) Long-term outcomes of elective human sperm cryostorage. Hum Reprod 16:2632–2639
Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N (2007) Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation 116:2694–2701
Kidson-Gerber GL, Francis S, Lindeman R (2008) Management and clinical outcomes of transfusion-dependent thalassae-mia major in an Australian tertiary referral clinic. Med J Aust 188:72–75
Kley HK, Strohmeyer G, Krüskemper HL (1979) Effect of testosterone application on hormone concentrations of andro-gens and estrogens in male patients with cirrhosis of the liver. Gastroenterology 76:235–241
Kley HK, Stremmel W, Kley JB, Schlaghecke R (1992) Testosterone treatment of men with idiopathic hemochroma-tosis. Clin Invest 70:566–572
Knigge U, Dejgaard A, Wollesen F, Ingerslev O, Bennett P, Christiansen PM (1983) The acute and long term effect of the H2-receptor antagonists cimetidine and ranitidine on the pituitary-gonadal axis in men. Clin Endocrinol 18:307–318
Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, Roudebush WE (2006) Impact of body mass index values on sperm quantity and quality. J Androl 27:450–452
Krassas GE, Pontikides N (2004) Male reproductive function in relation with thyroid alterations. Best Pract Res Clin Endocrinol Metab 18:183–195
Krassas GE, Tziomalos K, Papadopoulou F, Pontikides N, Perros P (2008) Erectile dysfunction in patients with hyper- and hypothyroidism: how common and should we treat? J Clin Endocrinol Metab 93:1815–1819
Kraus MR, Schafer A, Bentink T, Scheurlen M, Weissbrich B, Al-Taie O, Seufert J (2005) Sexual dysfunction in males with chronic hepatitis C and antiviral therapy: interferon-induced functional androgen deficiency or depression? J Endocrinol 185:345–352
Ku JH, Kim YH, Jeon YS, Lee NK (1999) The preventive effect of systemic treatment with interferon-alpha2B for infertility from mumps orchitis. BJU Int 84:839–842
Kumar BJ, Kurana ML, Ammini AC, Karmarkar MG, Ahuja MM (1990) Reproductive endocrine functions in men with primary hypothyroidism: effect of thyroxine replacement. Horm Res 34:215–218
La Spada AR, Wilson EM, Lubahn DB, Harding AE, Fischbeck KH (1991) Androgen receptor gene mutation in X-linked spinal and bulbar muscular atrophy. Nature 352:77–79
Lachiewicz AM, Dawson DV (1994) Do young boys with fragile X syndrome have macroorchidism? Pediatrics 93:992–995
Laghi F, Antonescu-Turcu A, Collins E, Segal J, Tobin DE, Jubran A, Tobin MJ (2005) Hypogonadism in men with chronic obstructive pulmonary disease: prevalence and quality of life. Am J Respir Crit Care Med 171:728–733
Lange D, Henning H, Schirren C (1978) Andrologische Untersuchungen bei der Immun-suppressiv-Therapie der chronisch-aggressiven Hepatitis. Andrologia 10:373–379
Laughlin GA, Barrett-Connor E, Bergstrom J (2008) Low serum testosterone and mortality in older men. J Clin Endocrinol Metab 93:68–75
Lin YM, Hsu CC, Lin JS (1999) Successful testicular sperm extraction and fertilization in an azoospermic man with post-pubertal mumps orchitis. BJU Int 83:526–527
Linnet L, Hjort T, Fogh-Andersen P (1981) Association between failure to impregnate after vasovasostomy and sperm agglu-tinins in semen. Lancet 1:117–119
Liu PY, Handelsman DJ (2004) Androgen therapy in non-gonadal disease. In: Nieschlag E, Behre HM (eds) Testosterone: action, deficiency and substitution. Cambridge University Press, Cambridge, pp 445–495
Liu PY, Wishart SM, Celermajer DS, Jimenez M, Pierro ID, Conway AJ, Handelsman DJ (2003a) Do reproductive hormones modify insulin sensitivity and metabolism in older men? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin. Eur J Endocrinol 148:55–66
Liu PY, Yee BJ, Wishart SM, Jimenez M, Jung DG, Grunstein RR, Handelsman DJ (2003b) The short-term effects of high dose testosterone on sleep, breathing and function in older men. J Clin Endocrinol Metab 88:3605–3613
Liu PY, Caterson ID, Grunstein RR, Handelsman DJ (2007) Androgens, obesity, and sleep-disordered breathing in men. Endocrinol Metab Clin North Am 36:349–363
Loprinzi CL, Kugler JW, Sloan JA, Mailliard JA, Krook JE, Wilwerding MB, Rowland KM, Jr., Camoriano JK, Novotny PJ, Christensen BJ (1999) Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymes-terone for the treatment of cancer anorexia/cachexia. J Clin Oncol 17:3299–3306
Loves S, Ruinemans-Koerts J, de Boer H (2008) Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism. Eur J Endocrinol 158:741–747
Luppa PB, Thaler M, Schulte-Frohlinde E, Schreiegg A, Huber U, Metzger J (2006) Unchanged androgen-binding properties of sex hormone-binding globulin in male patients with liver cirrhosis. Clin Chem Lab Med 44:967–973
Luton JP, Thieblot P, Valcke JC, Mahoudeau JA, Bricaire H (1977) Reversible gonadotropin deficiency in male Cushings disease. J Clin Endocrinol Metab 45:488–495
MacDonald ME, Ambrose CM, Duyao MP (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 72:971–983
Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K (2005) Persistent organochlo-rines, sedentary occupation, obesity and human male subfer-tility. Hum Reprod 20:208–215
Makarevich AE (2003) Disorders of sex hormone status in patients with chronic obstructive pulmonary disease. Wiad Lek 56:140–146
Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH, Channer KS (2004) Testosterone replacement in hypogo-nadal men with angina improves ischaemic threshold and quality of life. Heart 90:871–876
Malkin CJ, Jones RD, Jones TH, Channer KS (2006a) Effect of testosterone on ex vivo vascular reactivity in man. Clin Sci 111:265–274
Malkin CJ, Pugh PJ, West JN, van Beek EJ, Jones TH, Channer KS (2006b) Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J 27:57–64
Marin P, Holmang S, Jonsson L, Sjostrom L, Kvist H, Holm G, Lindstedt G, Bjorntorp P (1992a) The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Int J Obes Relat Metab Disord 16:991–997
Marin P, Krotkiewski M, Bjorntorp P (1992b) Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues. Eur J Med 1:329–336
Markianos M, Panas M, Kalfakis N, Vassilopoulos D (2005) Plasma testosterone in male patients with Huntington's disease: relations to severity of illness and dementia. Ann Neurol 57:520–525
Martens HF, Sheets PK, Tenover JS, Dugowson CE, Bremner WJ, Starkebaum G (1994) Decreased testosterone levels in men with rheumatoid arthritis: effect of low dose prednisone therapy. J Rheumatol 21:1427–1431
Martin FI, Maddocks I, Brown JB, Hudson B (1968) Leprous endocrinopathy. Lancet 2:1320–1321
Massa G, Vanderschueren-Lodeweyckx M, Van Vliet G, Craen M, de Zegher F, Eggermont E (1989) Hypothalamo-pituitary dysfunction in congenital toxoplasmosis. Eur J Pediatr 148:742–744
Mastrogiacomo I, Bonanni G, Menegazzo E, Santarossa C, Pagani E, Gennarelli M, Angelini C (1996) Clinical and hormonal aspects of male hypogonadism in myotonic dystrophy. Ital J Neurol Sci 17:59–65
Mastromauro CA, Meissen GJ, Cupples LA, Kiely DK, Berkman B, Myers RH (1989) Estimation of fertility and fitness in Huntington disease in New England. Am J Med Genet 33:248–254
Matsumoto A, Sandblom RE, Schoene RB, Lee KA, Giblin EC, Pierson DJ, Bremner WJ (1985) Testosterone replacement in hypogonadal men: effects on obstructive sleep apnea, respiratory drives and sleep. Clin Endocrinol 22:713–721
Meistrich ML, Beek MEAB van (1990) Radiation sensitivity of the human testis. Adv Radiation Biol 14:227–268
Meistrich M, Shetty G (2008) Hormonal suppression for fertility preservation in males and females. Reproduction [E-pub]
Mieusset R, Bujan L, Mansat A, Grandjean H, Pontonnier F (1991) Heat induced inhibition of spermatogenesis in man. Adv Exp Med Biol 286:233–237
Monks DA, Rao P, Mo K, Johansen JA, Lewis G, Kemp MQ (2008) Androgen receptor and Kennedy disease/spinal bul-bar muscular atrophy. Horm Behav 53:729–740
Neugebauer D, Neuwinger J, Jockenhovel F, Nieschlag E (1990) ‘9 + 0’ axoneme in spermatozoa and some nasal cilia of a patient with totally immotile spermatozoa associated with thickened sheath and short midpiece. Hum Reprod 5:981–986
O'Brien IAD, Lewin IG, O'Hare JP, Corrall RJM (1982) Reversible male subfertility due to hyperthyroidism. BMJ 285:691
O'Flaherty C, Vaisheva F, Hales BF, Chan P, Robaire B (2008) Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy. Hum Reprod 23:1044–1052
Obermayer-Straub P, Manns MP (1998) Autoimmune polyglan-dular syndromes. Baillieres Clin Gastroenterol 12:293–315
Oktenli C, Doganci L, Ozgurtas T, Araz RE, Tanyuksel M, Musabak U, Sanisoglu SY, Yesilova Z, Erbil MK, Inal A (2004) Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis: suppressive effect of inter-leukin-1 beta on the secretion of GnRH. Hum Reprod 19:859–866
Okun MS, DeLong MR, Hanfelt J, Gearing M, Levey A (2004) Plasma testosterone levels in Alzheimer and Parkinson diseases. Neurology 62:411–413
Okun MS, Fernandez HH, Rodriguez RL, Romrell J, Suelter M, Munson S, Louis ED, Mulligan T, Foster PS, Shenal BV, Armaghani SJ, Jacobson C, Wu S, Crucian G (2006) Testosterone therapy in men with Parkinson disease: results of the TEST-PD Study. Arch Neurol 63:729–735
Ozdemir BH, Ozdemir OG, Ozdemir FN, Ozdemir AI (2002) Value of testis biopsy in the diagnosis of systemic amyloido-sis. Urology 59:201–205
Pacini F, Gasperi M, Fugazzola L, Ceccarelli C, Lippi F, Centoni R, Martino E, Pinchera A (1994) Testicular function in patients with differentiated thyroid carcinoma treated with radioiodine. J Nucl Med 35:1418–1422
Pajarinen J, Karhunen PJ, Savolainen V, Lalu K, Penttila A, Laippala P (1996) Moderate alcohol consumption and disorders of human spermatogenesis. Alcohol Clin Exp Res 20:332–337
Parducz A, Hajszan T, Maclusky NJ, Hoyk Z, Csakvari E, Kurunczi A, Prange-Kiel J, Leranth C (2006) Synaptic remodeling induced by gonadal hormones: neuronal plasticity as a mediator of neuroendocrine and behavioral responses to steroids. Neuroscience 138:977–985
Perera D, Pizzey A, Campbell A, Katz M, Porter J, Petrou M, Irvine DS, Chatterjee R (2002) Sperm DNA damage in potentially fertile homozygous beta-thalassaemia patients with iron overload. Hum Reprod 17:1820–1825
Petersen PM, Skakkebaek NE, Rorth M, Giwercman A (1999) Semen quality and reproductive hormones before and after orchiectomy in men with testicular cancer. J Urol 161:822–826
Petitti DB (1986) Epidemiologic studies of vasectomy. In: Zatuchni GI, Goldsmith A, Spieler JM, Sciarra JJ (eds) Male contraception: advances and future prospects. Harper & Row, Philadelphia, PA, pp 24–33
Petzke F, Heppner C, Mbulamberi D, Winkelmann W, Chrousos GP, Allolio B, Reincke M (1996) Hypogonadism in Rhodesian sleeping sickness: evidence for acute and chronic dysfunction of the hypothalamic-pituitary-gonadal axis. Fertil Steril 65:68–75
Philip J, Selvan D, Desmond AD (2006) Mumps orchitis in the non-immune postpubertal male: a resurgent threat to male fertility? BJU Int 97:138–141
Pitteloud N, Hardin M, Dwyer AA, Valassi E, Yialamas M, Elahi D, Hayes FJ (2005) Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. J Clin Endocrinol Metab 90:2636–2641
Post FA, Soule SG, Willcox PA, Levitt NS (1994) The spectrum of endocrine dysfunction in active pulmonary tuberculosis. Clin Endocrinol 40:367–371
Prem AR, Punekar SV, Kalpana M, Kelkar AR, Acharya VN (1996) Male reproductive function in uraemia: efficacy of haemodialysis and renal transplantation. Br J Urol 78:635–638
Pridmore SA, Adams GC (1991) The fertility of HD-affected individuals in Tasmania. Aust N Z J Psychiatry 25:262–264
Puliyel MM, Vyas GP, Mehta GS (1977) Testosterone in the management of cirrhosis of the liver — a controlled study. AustrNZJ Med 7:17–30
Radford JA, Clark S, Crowther D, Shalet SM (1994) Male fertility after VAPEC-B chemotherapy for Hodgkin's disease and non-Hodgkin's lymphoma. Br J Cancer 69:379–381
Rajagopal A, Vassilopoulou-Sellin R, Palmer JL, Kaur G, Bruera E (2004) Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer 100:851–858
Reid IR, Wattie DJ, Evans MC, Stapleton JP (1996) Testosterone therapy in glucocorticoid-treated men. Arch Int Med 156:1173–1177
Rietschel P, Corcoran C, Stanley T, Basgoz N, Klibanski A, Grinspoon S (2000) Prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretrovi-ral therapy. Clin Infect Dis 31:1240–1244
Rimoin DL, Schimke RN (eds) (1971) The gonads. In: Genetic disorders of the endocrine glands. CV Mosby, St. Louis, MO
Robbins WA, Meistrich ML, Moore D, Hagemeister FB, Weier HU, Cassel MJ, Wilson G, Eskenazi B, Wyrobek AJ (1997) Chemotherapy induces transient sex chromosomal and auto-somal aneuploidy in human sperm. Nat Genet 16:74–78
Rovo A, Tichelli A, Passweg JR, Heim D, Meyer-Monard S, Holzgreve W, Gratwohl A, De Geyter C (2006) Spermatogenesis in long-term survivors after allogeneic hematopoi-etic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD. Blood 108:1100–1105
Rowley MJ, Leach DR, Warner GA, Heller CG (1974) Effect of graded doses of ionizing radiation on the human testis. Rad Res 59:665–678
Safarinejad MR (2008) Evaluation of semen quality, endocrine profile and hypothalamus-pituitary-testis axis in male patients with homozygous beta-thalassemia major. J Urol 179:2327–2332
Sakane T, Takeno M, Suzuki N, Inaba G (1999) Behcet's disease. N Engl J Med 341:1284–1291
Salehian B, Jacobson D, Swerdloff RS, Grafe MR, Sinha-Hikim I, McCutchan JA (1999) Testicular pathologic changes and the pituitary-testicular axis during human immunodeficiency virus infection. Endocr Pract 5:1–9
Sandblom RE, Matsumoto AM, Scoene RB, Lee KA, Giblin EC, Bremner WJ, Pierson DJ (1983) Obstructive sleep apnea induced by testosterone administration. N Engl J Med 308:508–510
Sarkar PS, Paul S, Han J, Reddy S (2004) Six5 is required for spermatogenic cell survival and spermiogenesis. Hum Mol Genet 13:1421–1431
Scalvini T, Martini PR, Gambera A, Tardanico R, Biasi L, Scolari F, Gregorini G, Agabiti Rosei E (2008) Spermatogenic and steroidogenic impairment of the testicle characterizes the hereditary leucine-75-proline apolipoprotein a-I amyloi-dosis. J Clin Endocrinol Metab 93:1850–1853
Schlatt S (1999) Prospects and problems for germ cell transplantation in the male. Int J Androl 22:13–18
Schneider BK, Pickett CK, Zwillich CW, Weil JV, McDermott MT, Santen RJ, Varano LA, White DP (1986) Influence of testosterone on breathing during sleep. J Appl Physiol 61:618–623
Schneider SA, Bhatia KP (2008) Dystonia in the Woodhouse Sakati syndrome: a new family and literature review. Mov Disord 23:592–596
Schover LR, Brey K, Lichtin A, Lipshultz LI, Jeha S (2002) Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol 20:1880–1889
Schramm P, Seyfeddinpur N (1980) Sperm analysis of patients after long term use of hydantoin. Andrologia 12:97–101
Schürmeyer T, Jung K, Nieschlag E (1984) The effect of an 1100 km run on testicular, adrenal and thyroid hormones. Int JAndrol 7:276–282
Seidman SN, Araujo AB, Roose SP, Devanand DP, Xie S, Cooper TB, McKinlay JB (2002) Low testosterone levels in elderly men with dysthymic disorder. Am J Psychiatry 159:456–459
Selvage DJ, Parsons L, Rivier C (2006) Role played by brain-stem neurons in regulating testosterone secretion via a direct neural pathway between the hypothalamus and the testes. Endocrinology 147:3070–3075
Semple CG, Robertson WR, Mitchell R, Gordon D, Gray CE, Beastall GH, Reid WH (1987) Mechanisms leading to hypogonadism in men with burns injuries. BMJ 295:403–407
Sicotte NL, Giesser BS, Tandon V, Klutch R, Steiner B, Drain AE, Shattuck DW, Hull L, Wang HJ, Elashoff RM, Swerdloff RS, Voskuhl RR (2007) Testosterone treatment in multiple sclerosis: a pilot study. Arch Neurol 64:683–688
Silva CA, Hallak J, Pasqualotto FF, Barba MF, Saito MI, Kiss MH (2002) Gonadal function in male adolescents and young males with juvenile onset systemic lupus erythematosus. J Rheumatol 29:2000–2005
Simon D, Charles MA, Lahlou N, Nahoul K, Oppert JM, Gouault-Heilmann M, Lemort N, Thibult N, Joubert E, Balkau B, Eschwege E (2001) Androgen therapy improves insulin sensitivity and decreases leptin level in healthy adult men with low plasma total testosterone: a 3-month randomized placebo-controlled trial. Diabetes Care 24:2149–2151
Singh AB, Norris K, Modi N, Sinha-Hikim I, Shen R, Davidson T, Bhasin S (2001) Pharmacokinetics of a transdermal testosterone system in men with end stage renal disease receiving maintenance hemodialysis and healthy hypogonadal men. J Clin Endocrinol Metab 86:2437–2445
Slowinska-Lisowska M, Majda J (2002) Hormone plasma levels from pituitary-gonadal axis in performance athletes after the 400 m run. J Sports Med Phys Fitness 42:243–249
Smith GD, Ben-Shlomo Y, Beswick A, Yarnell J, Lightman S, Elwood P (2005) Cortisol, testosterone, and coronary heart disease: prospective evidence from the Caerphilly study. Circulation 112:332–340
SomaliM, MpatakoiasV, AvramidesA, SakellariI, Kaloyannidis P, Smias C, Anagnostopoulos A, Kourtis A, Rousso D, Panidis D, Vagenakis A (2005) Function of the hypotha-lamic-pituitary-gonadal axis in long-term survivors of hematopoietic stem cell transplantation for hematological diseases. Gynecol Endocrinol 21:18–26
Southern KW (2007) Cystic fibrosis and formes frustes of CFTR-related disease. Respiration 74:241–251
SpectorTD, Perry LA, Tubb G, Silman AJ, Huskisson EC (1988) Low free testosterone levels in rheumatoid arthritis. Ann Rheum Dis 47:65–68
Spruit MA, Thomeer MJ, Gosselink R, Wuyts WA, Van Herck E, Bouillon R, Demedts MG, Decramer M (2007) Hypogonadism in male outpatients with sarcoidosis. Respir Med 101:2502–2510
Stahl NI, Decker JL (1978) Androgenic status of males with systemic lupus erythematosus. Arthr Rheum 21:665–668
Stikkelbroeck NM, Otten BJ, Pasic A, Jager GJ, Sweep CG, Noordam K, Hermus AR (2001) High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. J Clin Endocrinol Metab 86:5721–5728
Stillman MJ (2006) Testosterone replacement therapy for treatment refractory cluster headache. Headache 46:925–933
Strasser F, Palmer JL, Schover LR, Yusuf SW, Pisters K, Vassilopoulou-Sellin R, DeGracia B, Willey JS, Bruera E (2006) The impact of hypogonadism and autonomic dys function on fatigue, emotional function, and sexual desire in male patients with advanced cancer: a pilot study. Cancer 107:2949–2957
Stroud MA, Ritz P, Coward WA, Sawyer MB, Constantin-Teodosiu D, Greenhaff PL, Macdonald IA (1997) Energy expenditure using isotope-labelled water (2H218O), exercise performance, skeletal muscle enzyme activities and plasma biochemical parameters in humans during 95 days of endurance exercise with inadequate energy intake. Eur J Appl Physiol Occup Physiol 76:243–252
Suzuki H, Tominaga T, Kumagai H, Saruta T (1988) Effects of first-line antihypertensive agents on sexual function and sex hormones. J Hypertens Suppl 6:S649–651
Svartberg J, von Muhlen D, Schirmer H, Barrett-Connor E, Sundfjord J, Jorde R (2004) Association of endogenous testosterone with blood pressure and left ventricular mass in men. The Tromso Study. Eur J Endocrinol 150:65–71
Tan RS, Pu SJ (2003) A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease. Aging Male 6:13–17
Tanaka S, Togashi K, Rankinen T, Perusse L, Leon AS, Rao DC, Skinner JS, Wilmore JH, Despres JP, Bouchard C (2004) Sex differences in the relationships of abdominal fat to cardiovascular disease risk among normal-weight white subjects. Int J Obes Relat Metab Disord 28:320–323
Taneja N, Kucheria K, Jain S, Maheshwari MC (1994) Effect of phenytoin on semen. Epilepsia 35:136–140
Teruel JL, Marcen R, Navarro-Antolin J, AguileraA, Fernandez-Juarez G, Ortuno J (1996) Androgen versus erythropoietin for the treatment of anemia in hemodialyzed patients: a prospective study. J Am Soc Nephrol 7:140–144
Thon V, Harle P, Scholmerich J, Kuklinek P, Lokaj J, Straub RH (2007) Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hor mone conversion. Allergy 62:1320–1325
Tiitinen A, Valimaki M (2002) Primary infertility in 45-year-old man with untreated 21-hydroxylase deficiency: successful outcome with glucocorticoid therapy. J Clin Endocrinol Metab 87:2442–2445
Tomar R, Dhindsa S, Chaudhuri A, Mohanty P, Garg R, Dandona P (2006) Contrasting testosterone concentrations in type 1 and type 2 diabetes. Diabetes Care 29:1120–1122
Tondolo V, Citterio F, Panocchia N, Nanni G, Favi E, Brescia A, Castagneto M (2005) Gonadal function and immunosup-pressive therapy after renal transplantation. Transplant Proc 37:1915–1917
Travison TG, Araujo AB, Kupelian V, O'Donnell AB, McKinlay JB (2007) The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. J Clin Endocrinol Metab 92:549–555
Tzvetkov D, Tzvetkova P (2006) Tuberculosis of male genital system — myth or reality in 21st century. Arch Androl 52:375–381
Urban MD, Lee PA, Migeon CJ (1978) Adult height and fertility in men with congenital virilizing adrenal hyperplasia. N Engl J Med 299:1392–1396
van Leeuwen E, Wit FW, Prins JM, Reiss P, van der Veen F, Repping S (2007) Semen quality remains stable during 96 weeks of untreated human immunodeficiency virus-1 infection. Fertil Steril [Epub]
van Leeuwen E, Wit FW, Repping S, Eeftinck Schattenkerk JK, Reiss P, van der Veen F, Prins JM (2008) Effects of antiretro-viral therapy on semen quality. Aids 22:637–642
Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersen A, Bjorkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR, Leavitt BR (2007) Testicular degeneration in Huntington disease. Neurobiol Dis 26:512–520
van Thiel DH, Gavaler JS, Spero JA, Egler KM, Wight C, Sanghvi AT, HasibaU, Lewis JH (1981) Patterns of hypotha-lamic-pituitary-gonadal dysfunction in men with liver disease due to differing etiologies. Hepatology 1:39–46
van Thiel DH, Kumar S, Gavaler JS, Tarter RE (1990) Effect of liver transplantation on the hypothalamic-pituitary gonadal axis of chronic alcoholic men with advanced liver disease. Alcohol Clin Exp Res 14:478–481
Vazquez JA, Pinies JA, Martul P, de los Rios A, Gatzambide S, Busturia MA (1990) Hypothalamo-pituitary-testicular function in 70 patients with myotonic dystrophy. J Endocrinol Invest 13:375–379
Veldhuis JD, Wilkowski MJ, Zwart AD, Urban RJ, Lizarralde G, Iranmanesh A, Bolton WK (1993) Evidence for attenuation of hypothalamic gonadotropin-releasing hormone (GnRH) impulse strength with preservation of GnRH pulse frequency in men with chronic renal failure. J Clin Endocrinol Metab 76:648–654
Verpoest W, De Rademaeker M, Sermon K, De Rycke M, Seneca S, Papanikolaou E, Spits C, Van Landuyt L, Van der Elst J, Haentjens P, Devroey P, Liebaers I (2008) Real and expected delivery rates of patients with myotonic dystrophy undergoing intracytoplasmic sperm injection and preimplantation genetic diagnosis. Hum Reprod 23:1654–1660
Villalta J, Ballesca JL, Nicolas JM, Martinez de Osaba MJ, Antunez E, Pimentel C (1997) Testicular function in asymptomatic chronic alcoholics: relation to ethanol intake. Alcohol Clin Exp Res 21:128–133
Viviani S, Santoro A, Ragni G, Bonfante V, Bestetti O, Bonadonna G (1985) Gonadal toxicity after combination chemotherapy for Hodgkin's disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol 21:601–605
Viviani S, Ragni G, Santoro A, Perotti L, Caccamo E, Negretti E, Valagussa P, Bonadonna G (1991) Testicular dysfunction in Hodgkin's disease before and after treatment. Eur J Cancer 27:1389–1392
Wabitsch M, Ballauff A, Holl R, Blum WF, Heinze E, Remschmidt H, Hebebrand J (2001) Serum leptin, gonado-tropin, and testosterone concentrations in male patients with anorexia nervosa during weight gain. J Clin Endocrinol Metab 86:2982–2988
Wallock LM, Tamura T, Mayr CA, Johnston KE, Ames BN, Jacob RA (2001) Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers. Fertil Steril 75:252–259
Wang C, Tso SC, Todd D (1989) Hypogonadotropic hypogonad-ism in severe beta-thalassemia: effect of chelation and pulsatile gonadotropin-releasing hormone therapy. J Clin Endocrinol Metab 68:511–516
Warner CL, Griffin JE, Wilson JD, Jacobs LD, Murray KR, Fischbeck KH, Dickoff D, Griggs RC (1992) X-linked spinomuscular atrophy: a kindred with associated abnormal androgen receptor binding. Neurology 42:2181–2184
Webb CM, Elkington AG, Kraidly MM, Keenan N, Pennell DJ, Collins P (2008) Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease. Am J Cardiol 101:618–624
Whitehead E, Shalet SM, Blackledge G, Todd I, Crowther D, Beardwell CG (1982) The effects of Hodgkin's disease and combination chemotherapy on gonadal function in the adult male. Cancer 49:418–422
Woolf PD, Hamill RW, McDonald JV, Lee LA, Kelly M (1985) Transient hypogonadotropic hypogonadism caused by critical illness. J Clin Endocrinol Metab 60:444–450
Yadav R, Mehta SN, Kumar A, Guleria S, Seenu V, Tiwari SC (2008) A prospective analysis of testicular androgenic function in recipients of a renal allograft. Int Urol Nephrol 40(2):397–403
Zavos PM, Correa JR, Antypas S, Zarmakoupis-Zavos PN, Zarmakoupis CN (1998) Effects of seminal plasma from cigarette smokers on sperm viability and longevity. Fertil Steril 69:425–429
Zelissen PM, van Hattum J, Poen H, Scholten P, Gerritse R, te Velde ER (1988) Influence of salazosulphapyridine and 5-aminosalicylic acid on seminal qualities and male sex hormones. Scand J Gastroenterol 23:1100–1104
Zitzmann M, Rolf C, Nordhoff V, Schrader G, Rickert-Fohring M, Gassner P, Behre HM, Greb RR, Kiesel L, Nieschlag E (2003) Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 79(3):1550–1554
Zuber J, Anglicheau D, Elie C, Bererhi L, Timsit MO, Mamzer-Bruneel MF, Ciroldi M, Martinez F, Snanoudj R, Hiesse C, Kreis H, Eustache F, Laborde K, Thervet E, Legendre C (2008) Sirolimus may reduce fertility in male renal transplant recipients. Am J Transplant 8(7):1471–1479
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Sartorius, G.A., Handelsman, D.J. (2010). Testicular Dysfunction in Systemic Diseases. In: Nieschlag, E., Behre, H.M., Nieschlag, S. (eds) Andrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78355-8_18
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