• Andreas Hippe
  • Bernhard HomeyEmail author
  • Anja Mueller-Homey
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 180)


Tumor growth is restricted to approximately 2 μm diameters by simple dissociation of nutrients and oxygen. Hence, tumors require the formation of new blood vessels for further growth progression. This process is referred to as tumor neo-angiogenesis. The process of tumor neo-angiogenesis is directed by complex bidirectional interactions between the tumor and the vessels, and creates a favorable microenvironment for angiogenesis. The tumor vessel system not only facilitates tumor growth by providing nutrients and oxygen but also functions as a convenient route for metastasis.

A group of small cytokine-like molecules called chemokines have been shown to participate in angiogenesis under homeostatic and neoplastic conditions. This review summarizes their role in tumor-associated angiogenesis.


Vascular Endothelial Growth Factor Melanoma Cell Human Umbilical Vein Endothelial Cell Chemokine Receptor Mural Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Andreas Hippe
  • Bernhard Homey
    • 1
    Email author
  • Anja Mueller-Homey
  1. 1.Department of DermatologyHeinrich-Heine-UniversityDüsseldorfGermany

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