Given the large optical bandwidths required for OCT imaging, the combination of OCT with spectroscopic measurements is almost straightforward. In this chapter, the combination of morphologic and spectroscopic information from the OCT signals is discussed. With spectroscopic OCT (SOCT) [1–4], depth localized absorption spectra or spectral backscattering of native or foreign chromophores in the tissue can be measured, which can be used to enhance contrast in the OCT image or to extract functional information from the tissue. The next section will discuss the theoretical basis of SOCT. We start by briefly showing the equivalence of time (depth) and frequency (wave number) domain OCT and how to extract localized spectra from the OCT data. Next, the optical properties of tissue will be discussed. The sensitivity of the spectroscopic measurements is treated. We conclude this chapter with a section describing two major applications of SOCT: enhancing contrast in OCT images through spectral information and the measurement of localized oxygen saturation (functional SOCT).
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Faber, D.J., Aalders, M.C.G., Hermann, B., Drexler, W., van Leeuwen, T.G. (2008). Using Low Coherent Light for Spectroscopic Information from Tissue. In: Drexler, W., Fujimoto, J.G. (eds) Optical Coherence Tomography. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77550-8_23
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DOI: https://doi.org/10.1007/978-3-540-77550-8_23
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