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Virus Entry and Innate Immune Activation

  • Chapter
Human Cytomegalovirus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 325))

Human cytomegalovirus (HCMV) exhibits an exceptionally broad cellular tropism as it is capable of infecting most major organ systems and cell types. Definitive proof of an essential role for a cellular molecule that serves as an entry receptor has proven very challenging. It is widely hypothesized that receptor utilization, envelope glycoprotein requirements and entry pathways may all vary according to cell type, which is partially supported by the data. What has clearly emerged in recent years is that virus entry is not going undetected by the host. Robust and rapid induction of innate immune response is intimately associated with entry-related events. Here we review the state of knowledge on HCMV cellular entry mediators confronting the scientific challenges by accruing a definitive data set. We also review the roles of pattern recognition receptors such as Toll-like receptors in activation of specific innate immune response and discuss how entry events are tightly coordinated with innate immune initiation steps.

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References

  • Adlish JD, Lahijani RS, St Jeor SC (1990) Identification of a putative cell receptor for human cytomegalovirus. Virology 176:337–345

    Article  PubMed  CAS  Google Scholar 

  • Ahmad-Nejad P, Hacker H, Rutz M, Bauer S, Vabulas RM, Wagner H (2002) Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 32:1958–1968

    Article  PubMed  CAS  Google Scholar 

  • Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783–801

    Article  PubMed  CAS  Google Scholar 

  • Attar RM, Caamano J, Carrasco D, Iotsova V, Ishikawa H, Ryseck RP, Weih F, Bravo R (1997) Genetic approaches to study Rel/NF-kappa B/I kappa B function in mice. Semin Cancer Biol 8:93–101

    Article  PubMed  CAS  Google Scholar 

  • Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649–683

    Article  PubMed  CAS  Google Scholar 

  • Baldwin BR, Zhang CO, Keay S (2000) Cloning and epitope mapping of a functional partial fusion receptor for human cytomegalovirus gH. J Gen Virol 81:27–35

    PubMed  CAS  Google Scholar 

  • Beersma MF, Wertheim-van Dillen PM, Feltkamp TE (1990) The influence of HLA-B27 on the infectivity of cytomegalovirus for mouse fibroblasts. Scand J Rheumatol Suppl 87:102–103

    Article  PubMed  CAS  Google Scholar 

  • Beersma MF, Wertheim-van Dillen PM, Geelen JL, Feltkamp TE (1991) Expression of HLA class I heavy chains and beta 2-microglobulin does not affect human cytomegalovirus infectivity. J Gen Virol 72:2757–2764

    Article  PubMed  CAS  Google Scholar 

  • Beersma MF, Bijlmakers MJ, Geelen JL, Feltkamp TE (1992) HLA-B27 as a receptor for cytomegalovirus. Curr Eye Res 11 Suppl:141–146

    Article  PubMed  Google Scholar 

  • Beutler T, Hoflich C, Stevens PA, Kruger DH, Prosch S (2003) Downregulation of the epidermal growth factor receptor by human cytomegalovirus infection in human fetal lung fibroblasts. Am J Respir Cell Mol Biol 28:86–94

    Article  PubMed  CAS  Google Scholar 

  • Bodaghi B, Slobbe-van Drunen ME, Topilko A, Perret E, Vossen RC, van Dam-Mieras MC, Zipeto D, Virelizier JL, LeHoang P, Bruggeman CA, Michelson S (1999) Entry of human cytomegalovirus into retinal pigment epithelial and endothelial cells by endocytosis. Invest Ophthalmol Vis Sci 40:2598–2607

    PubMed  CAS  Google Scholar 

  • Boehme KW, Singh J, Perry ST, Compton T (2004) Human cytomegalovirus elicits a coordinated cellular antiviral response via envelope glycoprotein B. J Virol 78:1202–1211

    Article  PubMed  CAS  Google Scholar 

  • Boehme KW, Guerrero M, Compton T (2006) Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol 177:7094–7102

    PubMed  CAS  Google Scholar 

  • Bold S, Ohlin M, Garten W, Radsak K (1996) Structural domains involved in human cytomegalovirus glycoprotein B-mediated cell-cell fusion. J Gen Virol 77:2297–2302

    Article  PubMed  CAS  Google Scholar 

  • Boyle KA, Compton T (1998) Receptor-binding properties of a soluble form of human cytomegalovirus glycoprotein B. J Virol 72:1826–1833

    PubMed  CAS  Google Scholar 

  • Browne EP, Wing B, Coleman D, Shenk T (2001) Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs. J Virol 75:12319–12330

    Article  PubMed  CAS  Google Scholar 

  • Burzyn D, Rassa JC, Kim D, Nepomnaschy I, Ross SR, Piazzon I (2004) Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus. J Virol 78:576–584

    Article  PubMed  CAS  Google Scholar 

  • Cobbs CS, Soroceanu L, Denham S, Zhang W, Britt WJ, Pieper R, Kraus MH (2007) Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. J Neurooncol Jun 23; [Epub ahead of print]

    Google Scholar 

  • Compton T, Nepomuceno RR, Nowlin DM (1992) Human cytomegalovirus penetrates host cells by pH-independent fusion at the cell surface. Virology 191:387–395

    Article  PubMed  CAS  Google Scholar 

  • Compton T, Nowlin DM, Cooper NR (1993) Initiation of human cytomegalovirus infection requires initial interaction with cell surface heparan sulfate. Virology 193:834–841

    Article  PubMed  CAS  Google Scholar 

  • Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW (2003) Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 77:4588–4596

    Article  PubMed  CAS  Google Scholar 

  • DeFilippis VR, Robinson B, Keck TM, Hansen SG, Nelson JA, Fruh KJ (2006) Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. J Virol 80:1032–1037

    Article  PubMed  CAS  Google Scholar 

  • DeMeritt IB, Milford LE, Yurochko AD (2004) Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter. J Virol 78:4498–4507

    Article  PubMed  CAS  Google Scholar 

  • English EP, Chumanov RS, Gellman SH, Compton T (2006) Rational development of beta-peptide inhibitors of human cytomegalovirus entry. J Biol Chem 281:2661–2667

    Article  PubMed  CAS  Google Scholar 

  • Fairley JA, Baillie J, Bain M, Sinclair JH (2002) Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors. J Gen Virol 83:2803–2810

    PubMed  CAS  Google Scholar 

  • Feire AL, Koss H, Compton T (2004) Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain. Proc Natl Acad Sci USA 101:15470–15475

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T (2003) IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4:491–496

    Article  PubMed  CAS  Google Scholar 

  • Fortunato EA, McElroy AK, Sanchez I, Spector DH (2000) Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus. Trends Microbiol 8:111–119

    Article  PubMed  CAS  Google Scholar 

  • Gerondakis S, Grumont R, Rourke I, Grossmann M (1998) The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation. Curr Opin Immunol 10:353–359

    Article  PubMed  CAS  Google Scholar 

  • Gredmark S, Britt WB, Xie X, Lindbom L, Soderberg-Naucler C (2004) Human cytomegalovirus induces inhibition of macrophage differentiation by binding to human aminopeptidase N/CD13. J Immunol 173:4897–4907

    PubMed  CAS  Google Scholar 

  • Grundy JE, McKeating JA, Griffiths PD (1987a) Cytomegalovirus strain AD169 binds beta 2 microglobulin in vitro after release from cells. J Gen Virol 68:777–784

    Article  PubMed  CAS  Google Scholar 

  • Grundy JE, McKeating JA, Ward PJ, Sanderson AR, Griffiths PD (1987b) Beta 2 microglobulin enhances the infectivity of cytomegalovirus and when bound to the virus enables class I HLA molecules to be used as a virus receptor. J Gen Virol 68):793–803

    Article  PubMed  CAS  Google Scholar 

  • Hayden MS, West AP, Ghosh S (2006) NF-kappaB and the immune response. Oncogene 25:6758–6780

    Article  PubMed  CAS  Google Scholar 

  • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S, Hartmann G (2002) Quantitative expression of toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168:4531–4537

    PubMed  CAS  Google Scholar 

  • Huber MT, Compton T (1997) Characterization of a novel third member of the human cytomegalovirus glycoprotein H-glycoprotein L complex. J Virol 71:5391–5398

    PubMed  CAS  Google Scholar 

  • Huber MT, Compton T (1998) The human cytomegalovirus UL74 gene encodes the third component of the glycoprotein H-glycoprotein L-containing envelope complex. J Virol 72:8191–8197

    PubMed  CAS  Google Scholar 

  • Isaacson MK, Feire AL, Compton T (2007) The epidermal growth factor receptor is not required for human cytomegalovirus entry or signaling. J Virol 81:6241–6247

    Article  PubMed  CAS  Google Scholar 

  • Janeway CA Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197–216

    Article  PubMed  CAS  Google Scholar 

  • Kari B, Gehrz R (1992) A human cytomegalovirus glycoprotein complex designated gC-II is a major heparin-binding component of the envelope. J Virol 66:1761–1764

    PubMed  CAS  Google Scholar 

  • Kari B, Gehrz R (1993) Structure, composition and heparin binding properties of a human cytomegalovirus glycoprotein complex designated gC-II. J Gen Virol 74:255–264

    Article  PubMed  CAS  Google Scholar 

  • Keay S, Baldwin B (1991) Anti-idiotype antibodies that mimic gp86 of human cytomegalovirus inhibit viral fusion but not attachment. J Virol 65:5124–5128

    PubMed  CAS  Google Scholar 

  • Keay S, Baldwin B (1995) Update on the 92.5 kDa putative HCMV fusion receptor. Scand J Infect Dis Suppl 99:32–33

    PubMed  CAS  Google Scholar 

  • Keay S, Baldwin BR, Smith MW, Wasserman SS, Goldman WF (1995) Increases in [Ca2+]i mediated by the 92.5-kDa putative cell membrane receptor for HCMV gp86. Am J Physiol 269:C11–C21

    PubMed  CAS  Google Scholar 

  • Krug A, French AR, Barchet W, Fischer JA, Dzionek A, Pingel JT, Orihuela MM, Akira S, Yokoyama WM, Colonna M (2004a) TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21:107–119

    Article  PubMed  CAS  Google Scholar 

  • Krug A, Luker GD, Barchet W, Leib DA, Akira S, Colonna M (2004b) Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103:1433–1437

    Article  PubMed  CAS  Google Scholar 

  • Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW (2000) Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 1:398–401

    Article  PubMed  CAS  Google Scholar 

  • Laroux FS (2004) Mechanisms of inflammation: the good, the bad and the ugly. Front Biosci 9:3156–3162

    Article  PubMed  Google Scholar 

  • Larsson S, Soderberg-Naucler C, Moller E (1998) Productive cytomegalovirus (CMV) infection exclusively in CD13-positive peripheral blood mononuclear cells from CMV-infected individuals: implications for prevention of CMV transmission. Transplantation 65:411–415

    Article  PubMed  CAS  Google Scholar 

  • Lopper M, Compton T (2004) Coiled-coil domains in glycoproteins B and H are involved in human cytomegalovirus membrane fusion. J Virol 78:8333–8341

    Article  PubMed  CAS  Google Scholar 

  • Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198:513–520

    Article  PubMed  CAS  Google Scholar 

  • Mach M, Kropff B, Dal Monte P, Britt W (2000) Complex formation by human cytomegalovirus glycoproteins M (gpUL100) and N (gpUL73). J Virol 74:11881–11892

    Article  PubMed  CAS  Google Scholar 

  • McKeating JA, Grundy JE, Varghese Z, Griffiths PD (1986) Detection of cytomegalovirus by ELISA in urine samples is inhibited by beta 2 microglobulin. J Med Virol 18:341–348

    Article  PubMed  CAS  Google Scholar 

  • McKeating JA, Griffiths PD, Grundy JE (1987) Cytomegalovirus in urine specimens has host beta 2 microglobulin bound to the viral envelope: a mechanism of evading the host immune response? J Gen Virol 68:785–792

    Article  PubMed  CAS  Google Scholar 

  • Mocarski ES, Shenk T, Pass RF (2007) Cytomegaloviruses. In: Knipe DM, Howley PM (eds) Fields virology, vol 2, Lippincott Williams & Wilkins, Philadelphia, pp 2701–2772

    Google Scholar 

  • Navarro D, Paz P, Tugizov S, Topp K, La Vail J, Pereira L (1993) Glycoprotein B of human cytomegalovirus promotes virion penetration into cells, transmission of infection from cell to cell, and fusion of infected cells. Virology 197:143–158

    Article  PubMed  CAS  Google Scholar 

  • Navarro L, Mowen K, Rodems S, Weaver B, Reich N, Spector D, David M (1998) Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol Cell Biol 18:3796–3802

    PubMed  CAS  Google Scholar 

  • Netterwald JR, Jones TR, Britt WJ, Yang SJ, McCrone IP, Zhu H (2004) Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus. J Virol 78:6688–6691

    Article  PubMed  CAS  Google Scholar 

  • Nogalski MT, Podduturi JP, Demeritt IB, Milford LE, Yurochko AD (2007) The HCMV virion possesses an activated CKII that allows for the rapid phosphorylation of the inhibitor of NF-{kappa}B, I{kappa}B{alpha}. J Virol 81:5305–5314

    Article  PubMed  CAS  Google Scholar 

  • Nowlin DM, Cooper NR, Compton T (1991) Expression of a human cytomegalovirus receptor correlates with infectibility of cells. J Virol 65:3114–3121

    PubMed  CAS  Google Scholar 

  • Pietropaolo RL, Compton T (1997) Direct interaction between human cytomegalovirus glycoprotein B and cellular annexin II. J Virol 71:9803–9807

    PubMed  CAS  Google Scholar 

  • Pietropaolo R, Compton T (1999) Interference with annexin II has no effect on entry of human cytomegalovirus into fibroblast cells. J Gen Virol 80:1807–1816

    PubMed  CAS  Google Scholar 

  • Preston CM, Harman AN, Nicholl MJ (2001) Activation of interferon response factor-3 in human cells infected with herpes simplex virus type 1 or human cytomegalovirus. J Virol 75:8909–8916

    Article  PubMed  CAS  Google Scholar 

  • Raynor CM, Wright JF, Waisman DM, Pryzdial EL (1999) Annexin II enhances cytomegalovirus binding and fusion to phospholipid membranes. Biochemistry 38:5089–5095

    Article  PubMed  CAS  Google Scholar 

  • Real FX, Rettig WJ, Chesa PG, Melamed MR, Old LJ, Mendelsohn J (1986) Expression of epidermal growth factor receptor in human cultured cells and tissues: relationship to cell lineage and stage of differentiation. Cancer Res 46:4726–4731

    PubMed  CAS  Google Scholar 

  • Ryckman BJ, Jarvis MA, Drummond DD, Nelson JA, Johnson DC (2006) Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion. J Virol 80:710–722

    Article  PubMed  CAS  Google Scholar 

  • Sen GC (2001) Viruses and interferons. Annu Rev Microbiol 55:255–281

    Article  PubMed  CAS  Google Scholar 

  • Servant MJ, ten Oever B, LePage C, Conti L, Gessani S, Julkunen I, Lin R, Hiscott J (2001) Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. J Biol Chem 276:355–363

    Article  PubMed  CAS  Google Scholar 

  • Sharma S, TenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J (2003) Triggering the interferon antiviral response through an IKK-related pathway. Science 300:1148–1151

    Article  PubMed  CAS  Google Scholar 

  • Simmen KA, Singh J, Luukkonen BG, Lopper M, Bittner A, Miller NE, Jackson MR, Compton T, Fruh K (2001) Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B. Proc Natl Acad Sci USA 98:7140–7145

    Article  PubMed  CAS  Google Scholar 

  • Soderberg C, Giugni TD, Zaia JA, Larsson S, Wahlberg JM, Moller E (1993a) CD13 (human aminopeptidase N) mediates human cytomegalovirus infection. J Virol 67:6576–6585

    PubMed  CAS  Google Scholar 

  • Soderberg C, Larsson S, Bergstedt-Lindqvist S, Moller E (1993b) Definition of a subset of human peripheral blood mononuclear cells that are permissive to human cytomegalovirus infection. J Virol 67:3166–3175

    PubMed  CAS  Google Scholar 

  • Stannard LM (1989) Beta 2 microglobulin binds to the tegument of cytomegalovirus: an immunogold study. J Gen Virol 70:2179–2184

    Article  PubMed  CAS  Google Scholar 

  • Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD (1998) How cells respond to interferons. Annu Rev Biochem 67:227–264

    Article  PubMed  CAS  Google Scholar 

  • Takeda K, Akira S (2003) Toll receptors and pathogen resistance. Cell Microbiol 5:143–153

    Article  PubMed  CAS  Google Scholar 

  • Taniguchi T, Takaoka A (2002) The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol 14:111–116

    Article  PubMed  CAS  Google Scholar 

  • Taylor HP, Cooper NR (1990) The human cytomegalovirus receptor on fibroblasts is a 30-kilodalton membrane protein. J Virol 64:2484–2490

    PubMed  CAS  Google Scholar 

  • Theofilopoulos AN, Baccala R, Beutler B, Kono DH (2005) Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol 23:307–336

    Article  PubMed  CAS  Google Scholar 

  • Varnum SM, Streblow DN, Monroe ME, Smith P, Auberry KJ, Pasa-Tolic L, Wang D, Camp DG 2nd, Rodland K, Wiley S, Britt W, Shenk T, Smith RD, Nelson JA (2004) Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol 78:10960–10966

    Article  PubMed  CAS  Google Scholar 

  • Wang D, Shenk T (2005) Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropism. J Virol 79:10330–10338

    Article  PubMed  CAS  Google Scholar 

  • Wang X, Huong SM, Chiu ML, Raab-Traub N, Huang ES (2003) Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus. Nature 424:456–461

    Article  PubMed  CAS  Google Scholar 

  • Wang X, Huang DY, Huong SM, Huang ES (2005) Integrin alphavbeta3 is a coreceptor for human cytomegalovirus. Nat Med 11:515–521

    Article  PubMed  CAS  Google Scholar 

  • Weissenhorn W, Dessen A, Calder LJ, Harrison SC, Skehel JJ, Wiley DC (1999) Structural basis for membrane fusion by enveloped viruses. Mol Membr Biol 16:3–9

    Article  PubMed  CAS  Google Scholar 

  • Wright JF, Kurosky A, Wasi S (1994) An endothelial cell-surface form of annexin II binds human cytomegalovirus. Biochem Biophys Res Commun 198:983–989

    Article  PubMed  CAS  Google Scholar 

  • Wright JF, Kurosky A, Pryzdial EL, Wasi S (1995) Host cellular annexin II is associated with cytomegalovirus particles isolated from cultured human fibroblasts. J Virol 69:4784–4791

    PubMed  CAS  Google Scholar 

  • Wu QH, Trymbulak W, Tatake RJ, Forman SJ, Zeff RA, Shanley JD (1994) Replication of human cytomegalovirus in cells deficient in beta 2-microglobulin gene expression. J Gen Virol 75:2755–2759

    Article  PubMed  CAS  Google Scholar 

  • Yurochko AD, Huang ES (1999) Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expression. J Immunol 162:4806–4816

    PubMed  CAS  Google Scholar 

  • Yurochko AD, Kowalik TF, Huong SM, Huang ES (1995) Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters. J Virol 69:5391–5400

    PubMed  CAS  Google Scholar 

  • Yurochko AD, Hwang ES, Rasmussen L, Keay S, Pereira L, Huang ES (1997) The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection. J Virol 71:5051–5059

    PubMed  CAS  Google Scholar 

  • Zarember KA, Godowski PJ (2002) Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 168:554–561

    PubMed  CAS  Google Scholar 

  • Zhu H, Cong JP, Shenk T (1997) Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc Natl Acad Sci USA 94:13985–13990

    Article  PubMed  CAS  Google Scholar 

  • Zhu H, Cong JP, Mamtora G, Gingeras T, Shenk T (1998) Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sci USA 95:14470–14475

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Infectious Diseases, Novartis Institutes for Biomedical Research, 02139, Cambridge, MA, USA

    M. K. Isaacson

  2. McArdle Laboratory for Cancer Research, University of Wisconsin, 53706, Madison, WI, USA

    L. K. Juckem & T. Compton

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  1. M. K. Isaacson
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  2. L. K. Juckem
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  3. T. Compton
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Editors and Affiliations

  1. Princeton University, 08544-1014, Princeton, NJ, USA

    Thomas E. Shenk

  2. University of Iowa, 52242, Iowa, IA, USA

    Mark F. Stinski

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Isaacson, M.K., Juckem, L.K., Compton, T. (2008). Virus Entry and Innate Immune Activation. In: Shenk, T.E., Stinski, M.F. (eds) Human Cytomegalovirus. Current Topics in Microbiology and Immunology, vol 325. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77349-8_5

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