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Identification of Gene Regulatory Pathways: A Regularization Method

  • Mouli Das
  • Rajat K. De
  • Subhasis Mukhopadhyay
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4815)

Abstract

Network based pathways are emerging as an important paradigm for analysis of biological systems. In the present article, we introduce a new method for identifying a set of extreme regulatory pathways by using structural equations as a tool for modeling genetic networks. The method, first of all, generates data on reaction flows in a pathway. A set of constraints is formulated incorporating weighting coefficients. The effectiveness of the present method is demonstrated on two genetic networks existing in the literature. A comparative study with the existing extreme pathway analysis also forms a part of this investigation.

Keywords

flux balance analysis gene regulatory networks apoptosis incidence matrix yeast cell cycle 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Mouli Das
    • 1
  • Rajat K. De
    • 1
  • Subhasis Mukhopadhyay
    • 2
  1. 1.Machine Intelligence Unit, Indian Statistical Institute, Kolkata 700 108India
  2. 2.Bioinformatics Center, Department of Bio-Physics, Molecular Biology and Genetics, Calcutta University, Kolkata 700 009India

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