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Chemistry of Metal Radionuclides (Rb, Ga, In, Y, Cu and Tc)

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Molecular Imaging

Abstract

In the last four decades, a number of radiopharmaceuticals based on radiometals, such as 99mTc, 111In and 67Ga have been developed for both planar and SPECT imaging studies. Several positron emitting radiometals, specifically 64Cu, 68Ga and 89Zr have shown significant potential to develop molecular imaging probes based on PET. This chapter provides a broad overview of the production of radiometals and the importance of chelation chemistry in the development of metallic radiopharmaceuticals. Also, the advantages and disadvantages of various physico-chemical characteristics of radiometals such as half-life, specific activity, positron abundance and the energy of γ-photons are briefly explained. In addition, synthetic procedures involved in the preparation of 68Ga, 64Cu and 89Zr labeled molecular imaging probes based on peptides and proteins are reviewed. Finally, recent advances made in 99mTc chemistry and the synthetic approaches for the preparation of 99mTc labeled molecular imaging probes are briefly discussed at the end.

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(2009). Chemistry of Metal Radionuclides (Rb, Ga, In, Y, Cu and Tc). In: Molecular Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76735-0_12

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