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Abbreviations
- ALL:
-
Acute lymphoblastic leukemia
- DHT:
-
Dihydroxytestosterone
- FSH:
-
Follicle-stimulating hormone
- HD:
-
Hodgkin’s disease
- IMRT:
-
Intensity modulated radiation therapy
- ICSI:
-
Intracytoplasmic sperm injection
- LH:
-
Luteinizing hormone
- MOPP:
-
Mechlorethamine, vincristine, procarbazine, and prednisone
- NHL:
-
Non-Hodgkin’s lymphoma
- TBI:
-
Total body irradiation
- TESE:
-
Testis sperm extraction
References
Ahmed SR et al (1983) Primary gonadal damage following treatment of brain tumors in childhood. J Pediatr 103:562–565
Albers-Schonberg HE (1903) Uber ein bisher unbekannte wirkung der roengenstrahlen auf den organismus der tier. Munchen Med Wochenschr 50:1859–1860
Andersson AM et al (1998) Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels. J Clin Endocrinol Metab 83:4451–4458
Ash P (1980) The influence of radiation on fertility in man. Br J Radiol 53:271–278
Aubier F et al (1989) Male gonadal function after chemotherapy for solid tumors in childhood. J Clin Oncol 7:304–309
Bakker B et al (2000) Pubertal development and growth after total-body irradiation and bone marrow transplantation for haematological malignancies. Eur J Pediatr 159:31–37
Ben Arush MW et al (2000) Male gonadal function in survivors of childhood Hodgkin and non-Hodgkin lymphoma. Pediatr Hematol Oncol 17:239–245
Blatt J et al (1985) Leydig cell function in boys following treatment for testicular relapse of acute lymphoblastic leukemia. J Clin Oncol 3:1227–1231
Brauner R et al (1983) Leydig-cell function in children after direct testicular irradiation for acute lymphoblastic leukemia. N Engl J Med 309:25–28
Brinster RL (2002) Germline stem cell transplantation and transgenesis. Science 296:2174–2176
Brinster RL (2007) Male germline stem cells: from mice to men. Science 316:404–405
Brinster RL, Zimmermann JW (1994) Spermatogenesis following male germ-cell transplantation. Proc Natl Acad Sci U S A 91:11298–11302
Buchanan JD et al (1975) Return of spermatogenesis after stopping cyclophosphamide therapy. Lancet 2:156–157
Byrne J et al (1987) Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer. N Engl J Med 19:1315–1321
Casarett GW (1964) Long term effects of irradiation on sperm production of dogs. In: Carlson W and Gassner F (eds) Effects of Ionizing Radiation on the Reproduction System. Pergamon Press, New York
Castillo LA et al (1990) Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukaemia. Med Pediatr Oncol 18:185–189
Centola GM et al (1994) Effect of low-dose testicular irradiation on sperm count and fertility in patients with testicular seminoma. J Androl 15:608–613
Chan PTK et al (2001) Testicular sperm extraction combined with intracytoplasmic sperm injection in the treatment of men with persistent azoospermis postchemotherapy. Cancer 92:1632–1637
Charak BS et al (1990) Testicular dysfunction after cyclophosphamide-vincristine-procarbazine-prednisolone chemotherapy for advanced Hodgkin’s disease. A long-term follow-up study. Cancer 65:1903–1906
Colvin M (1982) The comparative pharmacology of cyclophosphamide and ifosfamide. Semin Oncol 9:2–7
Conte FA, Grumbach MM (1990) Pathogenesis, classification, diagnosis and treatment of anomalies of sex. In: Degroot LJ (ed) Endocrinology. WB Saunders, Philadelphia
Couto-Silva AC et al (2001) Factors affecting gonadal function after bone marrow transplantation during childhood. Bone Marrow Transplant 28:67–75
Czeizel A et al (1981) Genetics of undescended testes. J Urol 126:528
da Cunha MF et al (1984) Recovery of spermatogenesis after treatment for Hodgkin’s disease: limiting dose of MOPP chemotherapy. J Clin Oncol 2:571–577
Damani MN et al (2002) Postchemotherapy ejaculatory azoospermia: fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol 20:930–936
de Kretser DM, McFarlane JR (1996) Inhibin in the male. J Androl 17:179–182
Fraass BA et al (1985) Peripheral dose to the testes: the design and clinical use of a practical and effective gonadal shield. Int J Radiat Oncol Biol Phys 11:609–615
Ginsberg JP et al (2008) Sperm banking for adolescent and young adult cancer patients: sperm quality, patient, and parent perspectives. Pediatr Blood Cancer 50:594–598
Giwercman A et al (1991) Localized irradiation of testes with carcinoma in situ: effects on Leydig cell function and eradication of malignant germ cells in 20 patients. J Clin Endocrinol Metab 73:596–603
Group IMRTCW (2001) Intensity-modulated radiotherapy: current status and issues of interest. Int J Radiat Oncol Biol Phys 51:880–914
Hahn EW et al (1976) Aspermia and recovery of spermatogenesis in cancer patients following incidental gonadal irradiation during treatment: a progress report. Radiology 119:223–225
Hahn EW et al (1982) Recovery from aspermia induced by low-dose radiation in seminoma patients. Cancer 50:337–340
Hansen PV, Hansen SW (1993) Gonadal function in men with testicular germ cell cancer: the influence of cisplatin-based chemotherapy. Eur Urol 23:153–156
Hansen PV et al (1989) Testicular function in patients with testicular cancer treated with orchiectomy alone or orchiectomy plus cisplatin-based chemotherapy. J Natl Cancer Inst 81:1246–1250
Hassel JU et al (1991) Testicular function after OPA/COMP chemotherapy without procarbazine in boys with Hodgkin’s disease. Results in 25 patients of the DAL-HD-85 study. Klin Padiatr 203:268–272
Hayes FJ et al (1998) Differential control of gonadotropin secretion in the human: endocrine role of inhibin. J Clin Endocrinol Metab 83:1835–1841
Heikens J et al (1996) Irreversible gonadal damage in male survivors of pediatric Hodgkin’s disease. Cancer 78:2020–2024
Heyn R et al (1992) Late effects of therapy in patients with paratesticular rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee. J Clin Oncol 10:614–623
Hobbie WL et al (2005) Fertility in males treated for Hodgkins disease with COPP/ABV hybrid. Pediatr Blood Cancer 44:193–196
Howell S, Shalet S (1998) Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin North Am 27:927–943
Howell SJ, Shalet SM (2001) Testicular function following chemotherapy. Hum Reprod Update 7:363–369
Howell SJ, Shalet SM (2002) Effect of cancer therapy on pituitary-testicular axis. Int J Androl 25:269–276
Izard MA (1995) Leydig cell function and radiation: a review of the literature. Radiother Oncol 34:1–8
Jensen TK et al (1997) Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J Clin Endocrinol Metab 82:4059–4063
Johnson DH et al (1985) Effect of luteinizing hormone releasing hormone agonist given during combination chemotherapy on posttherapy fertility in male patients with lymphoma: preliminary observations. Blood 65:832–836
Kenney LB et al (2001) High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood. Cancer 91:613–621
Khan F (2003) The physics of radiation therapy. Lipincott Willimas and Wilkins, Philadelphia
Kinsella TJ et al (1989) Long-term follow-up of testicular function following radiation therapy for early-stage Hodgkin’s disease. J Clin Oncol 7:718–724
Koshy M et al (2004) Extra-target doses in children receiving multileaf collimator (MLC) based intensity modulated radiation therapy (IMRT). Pediatr Blood Cancer 42:626–630
Kreuser ED et al (1988) Reproductive and endocrine gonadal functions in adults following multidrug chemotherapy for acute lymphoblastic or undifferentiated leukemia. J Clin Oncol 6:588–595
Kulkarni SS et al (1997) Gonadal function following ABVD therapy for Hodgkin’s disease. Am J Clin Oncol 20:354–357
Lampe H et al (1997) Fertility after chemotherapy for testicular germ cell cancers. J Clin Oncol 15:239–245
Leiper AD et al (1986) Gonadal function after testicular radiation for acute lymphoblastic leukaemia. Arch Dis Child 61:53–56
Leiper AD et al (1987) The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function. Br J Haematol 67:419–426
Lin A, Ben-Josef E (2007) Intensity-modulated radiation therapy for the treatment of anal cancer. Clin Colorectal Cancer 6:716–719
Livesey EA, Brook CG (1988) Gonadal dysfunction after treatment of intracranial tumours. Arch Dis Child 63:495–500
Longhi A et al (2003) Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma. J Pediatr Hematol Oncol 25:292–296
Mackie EJ et al (1996) Gonadal function following chemotherapy for childhood Hodgkin’s disease. Med Pediatr Oncol 27:74–78
Marshall WA, Tanner JM (1970) Variation in pattern of pubertal changes in boys. Arch Dis Child 45:13–23
Meistrich ML, Vassilopoulou-Sellin R, Lipshultz LI (2005) Gonadal dysfunction. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer: priniciples and practice of oncology, 7th edn. Lippineott Williams and Wilkins, New York, pp 2560–2574
Milano MT et al (2005) Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 63:354–361
Moore KL (1988) The urogenital system. The developing human. W.B. Saunders Company, Toronto
Morris ID (1996) The testis: endocrine function. In: Hiller SG et al (eds) Scientific essentials of reproductive medicine. W.B. Saunders, London, pp 160–171
Muller U, Stahel RA (1993) Gonadal function after MACOP-B or VACOP-B with or without dose intensification and ABMT in young patients with aggressive non-Hodgkin’s lymphoma. Ann Oncol 4:399–402
Muller J et al (2000) Cryopreservation of semen from pubertal boys with cancer. Med and Ped Oncol 34:191–194
O’Dell WD (1989) Puberty. In: DeGroot LJ (ed) Endocrinology, 2nd edn. W.B. Saunders, Philadelphia
Ogilvy-Stuart AL et al (1992) Endocrine deficit after fractionated total body irradiation. Arch Dis Child 67:1107–1110
Ortin TT et al (1990) Gonadal status and reproductive function following treatment for Hodgkin’s disease in childhood: the Stanford experience. Int J Radiat Oncol Biol Phys 19:873–880
Orwig KE, Schlatt S (2005) Cryopreservation and transplantation of spermatogonia and testicular tissue for preservation of male fertility. J Natl Cancer Inst Monogr 34:51–56
Palermo GD et al (1995) Intracytoplasmic sperm injection: a novel treatment for all forms of male factor infertility. Fertil Steril 63:1231–1240
Papadakis V et al (1999) Gonadal function in young patients successfully treated for Hodgkin disease. Med Pediatr Oncol 32:366–372
Pedrick TJ, Hoppe RT (1986) Recovery of spermatogenesis following pelvic irradiation for Hodgkin’s disease. Int J Radiat Oncol Biol Phys 12(1):117–121
Petersen PM et al (1999) Undetectable inhibin B serum levels in men after testicular irradiation. J Clin Endocrinol Metab 84:213–215
Petersen PM et al (2002) Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-in situ in the testis. J Clin Oncol 20:1537–1543
Pfeifer SM, Coutifaris C (1999) Reproductive technologies 1998: options available for the cancer patient. Med and Ped Oncol 33:34–40
Pryzant RM et al (1993) Long-term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin’s lymphomas. J Clin Oncol 11:239–247
Radford JA et al (1994) Male fertility after VAPEC-B chemotherapy for Hodgkin’s disease and non-Hodgkin’s lymphoma. Br J Cancer 69:379–381
Regaud C, Blanc J (1906) Extreme sensibilite des spermatogonies a ces rayons. C R Soc Biol Paris 61:163–165
Rivkees SA, Crawford JD (1988) The relationship of gonadal activity and chemotherapy-induced gonadal damage. JAMA 259:2123–2125
Sandeman TF (1966) The effects of x irradiation on male human fertility. Br J Radiol 39:901–907
Sanders JE et al (1986) Growth and development following marrow transplantation for leukemia. Blood 68:1129–1135
Sarafoglou K et al (1997) Gonadal function after bone marrow transplantation for acute leukemia during childhood. J Pediatr 130:210–216
Schilsky RL (1989) Infertility in patients with testicular cancer: testis, tumor, or treatment? J Natl Cancer Inst 81:1204–1205
Schmiegelow M et al (2001) Gonadal status in male survivors following childhood brain tumors. J Clin Endocrinol Metab 86:2446–2452
Shalet SM et al (1985) Leydig cell damage after testicular irradiation for lymphoblastic leukaemia. Med Pediatr Oncol 13:65–68
Shalet SM et al (1989) Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol 120:161–165
Shapiro E et al (1985) Effects of fractionated irradiation of endocrine aspects of testicular function. J Clin Oncol 3:1232–1239
Sklar C (1999) Reproductive physiology and treatment-related loss of sex hormone production. Med Pediatr Oncol 33:2–8
Sklar CA et al (1990) Effects of radiation on testicular function in long-term survivors of childhood acute lymphoblastic leukemia: a report from the Children Cancer Study Group. J Clin Oncol 8:1981–1987
Smith EP et al (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056–1061
Smith KD, Rodgriguez-Rigau LJ (1989) Laboratory evaluation of testicular function. In: Degroot LJ (ed) Endocrinology. W.B. Saunders, Philadelphia
Speiser B et al (1973) Aspermia following lower truncal irradiation in Hodgkin’s disease. Cancer 32:692–698
Spitz S (1948) The histological effects of nitrogen mustards on human tumors and tissues. Cancer 1:383–398
Steinberger E (1989) Structural consideration of the male reproductive system. In: DeGrooT LJ (ed) Endocrinology. W.B. Saunders, Philadelphia
Styne DM (1982) The testes: disorders of sexual differentiation and puberty. In: Kaplan SA (ed) Clinical pediatric endocrinology. W. B. Saunders, Philadelphia
Thomson AB et al (2002) Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: a case-control study. Lancet 360:361–367
Tsatsoulis A et al (1990) Immunoactive inhibin as a marker of Sertoli cell function following cytotoxic damage to the human testis. Horm Res 34:254–259
Viviani S et al (1985) Gonadal toxicity after combination chemotherapy for Hodgkin’s disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol. 21:601–605
Wallace WH et al (1991) Male fertility in long-term survivors of childhood acute lymphoblastic leukaemia. Int J Androl 14:312–319
Watson AR et al (1985) Long-term effects of cyclophosphamide on testicular function. Br Med J 291:1457–1460
Waxman JH et al (1987) Failure to preserve fertility in patients with Hodgkin’s disease. Cancer Chemother Pharmacol 19:159–162
Willemse PH et al (1983) Altered Leydig cell function in patients with testicular cancer: evidence for bilateral testicular defect. Acta Endocrinol (Copenh) 102:616–624
Recommended Reading
Fajardo LF, Bethrong M, Anderson RE (2001) Testis in radiation pathology. Oxford University Press, New York
Jordon JW (1971) Late gonadal radiation effects. Hum Pathol 2:551–558
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Ginsberg, J.P., Katz, A.W. (2014). The Testes. In: Rubin, P., Constine, L., Marks, L. (eds) ALERT • Adverse Late Effects of Cancer Treatment. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75863-1_20
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