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Computational Modelling of the Biomechanics of Epithelial and Mesenchymal Cell Interactions During Morphological Development

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Computational Intelligence in Medical Informatics

Part of the book series: Studies in Computational Intelligence ((SCI,volume 85))

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Computational modelling of morphological development of tissues based on complex systems and cellular automata can be decomposed into three interdependenent processes. Those three crucial parts are mechanical response of tissues, diffusion of signalling molecules, and gene regulatory network. It is shown that development of an adequate mechanical model of living tissues provides the morphological model with sufficient flexibility necessary to achieve expected morphological development scenarios. In this contribution, the attention is focussed to development of mesenchymal and epithelial tissues which, e.g., creates the basic mechanism of tooth development. The future development of the model is discussed with emphasis on open questions.

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Author information

Authors and Affiliations

  1. Department of Mechanics, University of West Bohemia, Univerzitni 22, 306 14, Pilsen, Czech Republic

    Jiří Kroc

Authors
  1. Jiří Kroc
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Editor information

Editors and Affiliations

  1. Buffalo Neuroimaging Analysis Center The Jacobs Neurological Institute University at Buffalo, The State University of New York, 100 High Street, Buffalo, NY, 14203, USA

    Arpad Kelemen

  2. Centre for Quantifiable Quality of Service in Communication Systems (Q2S) Centre of Excellence, Norwegian University of Science and Technology, O.S. Bragstads plass 2E, N-7491, Trondheim, Norway

    Ajith Abraham

  3. Biostatistics Dept. University at Buffalo, The State University of New York, 252A2 Farber Hall, 3435 Main st., Buffalo, NY, 14214, USA

    Yulan Liang

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© 2008 Springer-Verlag Berlin Heidelberg

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Kroc, J. (2008). Computational Modelling of the Biomechanics of Epithelial and Mesenchymal Cell Interactions During Morphological Development. In: Kelemen, A., Abraham, A., Liang, Y. (eds) Computational Intelligence in Medical Informatics. Studies in Computational Intelligence, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75767-2_13

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  • DOI: https://doi.org/10.1007/978-3-540-75767-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-75766-5

  • Online ISBN: 978-3-540-75767-2

  • eBook Packages: EngineeringEngineering (R0)

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