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Hematological Neoplasms

  • Chapter
Intraocular Inflammation

Abstract

Hematologic neoplasms comprise multiple malignant diseases derived from cells of myeloid or lymphocytic hematopoietic lineages. Hence, the classification of these disorders is primarily based on the hematopoietic lineage into lymphoid and myeloid neoplasms. In recent years, great progress has been made in the differentiation of disease entities and the definition of their specific properties leading to directed treatment and distinct prognostic evaluation. Also, the classification of hematologic neoplasms has evolved tremendously. In 2008, the World Health Organization (WHO) published its latest consensus criteria that incorporated a precise definition of morphology, immunophenotype, molecular markers, and clinical properties. According to these criteria lymphomas are grouped into lymphatic precursor neoplasms, mature B-, T-, and NK-cell neoplasms, Hodgkin’s lymphoma, and posttransplantation lymphoproliferative diseases (PTLD). Myeloid neoplasias and leukemia are subdivided into myeloproliferative neoplasms (MPN), myeloid and lymphoid neoplasms associated with eosinophilia, myelodysplastic/myeloproliferative neoplasms (MDS/MPN), myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), acute leukemias of ambiguous lineage, B-lymphoblastic leukemia/lymphoma, and T-lymphoblastic leukemia. Of note, differentiation between acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma is obvious when a patient presents with masses composed of B or T lymphoblasts without detection of blasts in the bone marrow or peripheral blood. Therefore, lymphoblastic neoplasms are incorporated into both lymphoid (lymphoblastic lymphoma) and leukemia (ALL) classification criteria.

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Author information

Authors and Affiliations

  1. Center of Ophthalmology, University of Tuebingen, Tuebingen, Germany

    Manfred Zierhut MD

  2. Department of Internal Medicine, University of Tuebingen, Tuebingen, Germany

    Sebastian P. Haen MD & Robert Moehle MD

  3. Section of Immunopathology, Laboratory of Immunology, National Eye Institute, Bethesda, MD, USA

    Chi-Chao Chan MD

Authors
  1. Manfred Zierhut MD
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  2. Sebastian P. Haen MD
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  3. Robert Moehle MD
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  4. Chi-Chao Chan MD
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Corresponding author

Correspondence to Manfred Zierhut MD .

Editor information

Editors and Affiliations

  1. Centre of Ophthalmology, University of Tuebingen, Tuebingen, Germany

    Manfred Zierhut

  2. Biomedical Research Centre, Institute of Ophthalmology, Moorfields Eyes Hospital, Department of Medical Retina, UCL, London, United Kingdom

    Carlos Pavesio

  3. School of Medicine, Department of Ophthalmology, Hokkaido University Graduate, Sapporo, Hokkaido, Japan

    Shigeaki Ohno

  4. University of Belo Horizonte, Belo Horizonte, Brazil

    Fernando Orefice

  5. USC Eye Institute, University of Southern California, Los Angeles, California, USA

    Narsing A. Rao

1 Electronic Supplementary Material

Below is the link to the electronic supplementary material.

Case Report 31

Acute myelogenous lymphoma masquerading as VKH disease (PPT 21371 kb)

Case Report 34

Bilateral endogenous bacterial endophthalmitis and bacteraemia as the presenting manifestation of multiple myeloma (PPTX 5737 kb)

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Zierhut, M., Haen, S.P., Moehle, R., Chan, CC. (2016). Hematological Neoplasms. In: Zierhut, M., Pavesio, C., Ohno, S., Orefice, F., Rao, N. (eds) Intraocular Inflammation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75387-2_149

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  • DOI: https://doi.org/10.1007/978-3-540-75387-2_149

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-75385-8

  • Online ISBN: 978-3-540-75387-2

  • eBook Packages: MedicineMedicine (R0)

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