Structure-Function Relationships Among RNA-Dependent RNA Polymerases

  • Kenneth K.-S. Ng
  • Jamie J. Arnold
  • Craig E. Cameron
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 320)


RNA-dependent RNA polymerases (RdRPs) play key roles in viral transcription and genome replication, as well as epigenetic and post-transcriptional control of cellular gene expression. In this article, we review the crystallographic, biochemical, and molecular genetic data available for viral RdRPs that have led to a detailed description of substrate and cofactor binding, fidelity of nucleotide selection and incorporation, and catalysis. It is likely that the cellular RdRPs will share some of the basic structural and mechanistic principles gleaned from studies of viral RdRPs. Therefore, studies of the viral RdRP establish a framework for the study of cellular RdRPs, an important yet understudied class of nucleic acid polymerases.


Bovine Viral Diarrhea Virus Rabbit Hemorrhagic Disease Virus Elongation Complex Feline Calicivirus RdRP Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Kenneth K.-S. Ng
    • 1
  • Jamie J. Arnold
  • Craig E. Cameron
    • 2
  1. 1.Department of Biological SciencesUniversity of CalgaryCalgaryCanada
  2. 2.Department of Biochemistry and Molecular Biology The Pennsylvania State UniversityUniversity ParkUSA

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