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Anderson PD, D’Aco VJ, Shanahan P, Chapra SC, Buzby ME, Cunningham VL, DuPlessie BM, Hayes EP, Mastrocco F, Parke NJ, Rader JC, Samuelian JH, Schwab BW (2004) Screening analysis of human pharmaceutical compounds in U.S. surface waters. Environ Sci Technol 38:838–849
Axelrod J, Inscoe JK, Tomkins GM (1961) Enzymatic synthesis of N-glucosyluronic acid conjugates. J Biol Chem 232:835–841
Cowan CE, Larson RJ, Feijtel TCJ, Rapaport RA (1993) An improved model for predicting the fate of consumer pro duct chemicals in wastewater treatment plants. Water Res 27:561–573
EPA (1996) Clean Water Needs Survey for the United States and U.S.Territories; U.S. EPA: Washington,DC, 1997 (Information regarding the Needs Survey is available on the Internet at textit http://www.epa.gov/ owm)
EPA (2001) Better Assessment Science Integrating Point and Nonpoint Source, BASINS, Version 3.0; Report Number EPA-823-B-01-001; Office of Water, U.S. EPA: Washington, DC,June 2001
EMEA (2006) Note for Guidance on Environmental Risk Assessment of Medicinal Products for Human Use, CMCP/SWP/4447/draft, The European Agency for the Evaluation of Medicinal Products, London, England, 2005 (http://www.emea.eu.int/pdfs/human/swp/444700en.pdf)
EU (2003) Technical Guidance Document on Risk Assessment. Part II:European Communities, Table 16, p20
FDA (1998) Guidance for Industry – Environmental Assessment of Human Drug and Biologics. Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER),U. F. a. D. Administration, Rockville, Maryland (http://www.fda.gov/cder/guidance/index.html)
Feijtel TCJ, Boeije G, Matthies M, Young A, Morris G, Gandolfi C,Hansen B, Fox K, Holt M, Koch V,Schroder R, Cassani G, Schowanek D, Rosenblom J, Niessen H (1997) Development of a geographyreferenced regional exposure assessment tool for European rivers – GREAT-ER.Contribution to GREAT-ER # 1. Chemosphere 34:2351–2373
Fox KK, Daniel M, Morris G, Holt M (2000) The use of measured boron concentration data from the GREAT-ER UK validation study (1996–1998) to generate predicted regional boron concentrations. Sci Total Environ 251/252:305–316
Halling-Sørensen B, Nielsen SN, Lanzky PF, Ingerslev F,Lützhøft HC, Jørgensen SE (1998) Occurrence,fate and effects of pharmaceutical substances in the environment – a review. Chemosphere 36:357–393
Heberer T (2002). Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of current research data. Toxicol Lett 131:5–17
Johnson AC, Williams RJ, Simpson P, Kanda K (2007) What difference might sewage treatment performance make to endocrine disruption in rivers? Environ Poll 147:194–202
McAvoy DC, Eckhoff WS, Rapaport RA (1993) Fate of linear alkylbenzene sulfonate in the environment. Environ Toxicol Chem 12:977–987
Panter GH, Thompson RS, Beresford N, Sumpter JP (1999)Transformation of a non-oestrogenic steroid metabolite to an oestrogenically active substance by minimal bacterial activity. Chemosphere 38:3570–3596
Rapaport RA (1988) Prediction of consumer product chemical concentrations as a function of publicly owned treatment works treatment type and river dilution. Environ Toxicol Chem 7:107–115
Ronse Y (2007) VMM Vlaamse MilieuMaatschappij (personal communication) Schroder FR, Schulze C, Matthies M (2002) Concentration of LAS and boron in the Itter. Comparison of measured data with results obtained by simulation with the GREAT-ER software. Environ Sci Pollut Res Int 9:130–135
Schowanek D, Webb S. (2002) Exposure simulation for pharmaceuticals in European surface waters with GREAT-ER. Toxicol Lett 131:39–50
Struijs J, Stoltenkamp J, Van de Meent DA (1991) Spreadsheet-based model to predict the fate of xenobiotics in a municipal wastewater treatment plant. Water Res 25:891–900
Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water Res 12:3245–3260
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Cunningham, V.L. (2008). Environmental Exposure Modeling: Application of PhATE™ and Great-ER to Human Pharmaceuticals in the Environment. In: Kümmerer, K. (eds) Pharmaceuticals in the Environment. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74664-5_10
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DOI: https://doi.org/10.1007/978-3-540-74664-5_10
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