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Urosepsis

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Book cover Pediatric Nephrology in the ICU

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Core Messages

  • The development of bacteremia from a urinary focus is called urosepsis.

  • Urosepsis as a result of urinary tract infection (UTI) is commonly caused by Gram-negative bacteria.

  • Early identification and treatment of urosepsis in infants and children is very crucial.

  • Urosepsis can lead to systemic symptoms that may result in multiorgan failure.

  • Patients with urosepsis who have systemic symptoms are best managed in the intensive care setting.

  • Optimum management of urosepsis requires collaboration between several subspecialties.

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References

  1. Bauchner H, Philipp B, Dashefsky B, et al. (1987) Prevalence of bacteriuria in febrile children. Pediatr Infect Dis J 6:239–242

    Article  PubMed  CAS  Google Scholar 

  2. Beale RJ, Hollenberg SM, Vincent JL, et al. (2004) Vasopressor and inotropic support in septic shock: an evidence-based review. Crit Care Med 32(11 Suppl):455–465

    Article  Google Scholar 

  3. Benjamin DK, Poole C, Steinbach WJ, et al. (2003) Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques. Pediatrics 112(3, Part 1):634–640

    Article  PubMed  Google Scholar 

  4. Bernard GR, Vincent JL, Laterre F, et al. (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344(10):699–709

    Article  PubMed  CAS  Google Scholar 

  5. Bochud PY, Bonten M, Marchetti O, et al. (2004) Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review. Crit Care Med 32(11 Suppl):495–512

    Article  CAS  Google Scholar 

  6. Bryant K, Maxfield C, Rabalais G (1999) Renal candidiasis in neonates with candiduria. Pediatr Infect Dis J 18:959–963

    Article  PubMed  CAS  Google Scholar 

  7. Chon HC, Lai FC, Shortliffe LD (2001) Pediatric urinary tract infections. Pediatr Clin North Am 48:1441–1459

    Article  PubMed  CAS  Google Scholar 

  8. Coppa G, Gabrielli O, Giorgi P, et al. (1990) Preliminary study of breastfeeding and bacterial adhesion to uroepithelial cells. Lancet 335:569–571

    Article  PubMed  CAS  Google Scholar 

  9. Dellinger R P, Carlet JM, Masur H, et al. (2004) Surviving sepsis: campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32(3):858–873

    Article  PubMed  Google Scholar 

  10. Donnenberg MS, Welch RA (1996) Virulence determinants of uropathogenicEscherichia coli. In: Mobley HLT, Warren JW (eds) Urinary tract infections: molecular pathogenesis and clinical management. ASM Press, Washington, DC

    Google Scholar 

  11. Dow G, Rao P, Harding G (2004) A prospective, randomized trial of 3 or 14 days of ciprofloxacin treatment for acute urinary tract infection in patients with spinal cord injury. Clin Infect Dis 39:658–664

    Article  PubMed  CAS  Google Scholar 

  12. Eisenstein BI, Jones GW (1988) The spectrum of infections and pathogenic mechanisms ofEscherichia coli. Adv Intern Med 33:231–252

    PubMed  CAS  Google Scholar 

  13. Florquin S, van den Berg JG, Olszyna D P, et al. (2001) Release of urokinase plasminogen activator receptor during urosepsis and endotoxemia. Kidney Int 59:2054–2061

    PubMed  CAS  Google Scholar 

  14. Gainer JA, Yost NP (2003) Critical care infectious disease. Obstet Gynecol Clin North Am 30(4):695–709

    Article  PubMed  Google Scholar 

  15. Gea-Banacloche JC, Opal SM, Jorgensen J, et al. (2004) Sepsis associated with immunosuppressive medications: an evidence-based review. Crit Care Med 32(11 Suppl):578–590

    Article  Google Scholar 

  16. Ginsburg CM, McCracken GH (1982) Urinary tract infections in young infants. Pediatrics 69(4):409–412

    PubMed  CAS  Google Scholar 

  17. Goldman (2004) Urinary tract infections. In: Cecil textbook of medicine, 22nd edn. Saunders, Philadelphia, PA, Chapter 344

    Google Scholar 

  18. Hanson LA (1976) Esch. coli infections in childhood significance of bacterial virulence and immune defense. Arch Dis Child 51:737–742

    Article  PubMed  CAS  Google Scholar 

  19. Hanson LA, Korotkova M, Haversen L, et al. (2002) Breastfeeding, a complex support system for the offspring. Pediatr Int 44:347–352

    PubMed  Google Scholar 

  20. Haversen L, Ohlsson BG, Hahn-Zoric M, et al. (2002) Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B. Cell Immunol 220:83–95

    Article  PubMed  CAS  Google Scholar 

  21. Hoberman A, Chao H P, Keller DM, et al. (1993) Prevalence of urinary tract infection in febrile infants. J Pediatr 123:17–23

    Article  PubMed  CAS  Google Scholar 

  22. Hrair-George O, Mesrobian, MD, Balcom, AH, et al. (2004) Urologic problems of the neonate. Pediatr Clin of North Am 51:4

    Google Scholar 

  23. Karlowicz MG (2003) Candidal renal and urinary tract infection in neonates. Semin Perinatol 27:393–400

    Article  PubMed  Google Scholar 

  24. Kauffman CA, Vazquez JA, Sobel JD, et al. (2000) Prospective multicenter surveillance study of funguria in hospitalized patients. The National Institute for Allergy and Infectious Diseases (NIAID) Mycoses Study Group. Clin Infect Dis 30:14–18

    Article  PubMed  CAS  Google Scholar 

  25. Langley JM (2005) Defining urinary tract infection in the critically ill child. Pediatr Crit Care Med 6:25–29

    Article  Google Scholar 

  26. Langley JM, Hanakowski M, Leblanc JC (2001) Unique epidemiology of nosocomial urinary tract infection in children. Am J Infect Control 29(2):94–98

    Article  PubMed  CAS  Google Scholar 

  27. Lundstrom T, Sobel J (2001) Nosocomial candiduria. Clin Infect Dis 32:1602–1607

    Article  PubMed  CAS  Google Scholar 

  28. Ma J F, Dairiki Shortliffe LM (2004) Urinary tract infection in children: etiology and epidemiology. Urol Clin North Am 31(3):517–526

    Article  PubMed  Google Scholar 

  29. Magee CC, Milford EL (2004) Clinical aspects of renal transplantation. In: Brenner BM (ed) Brenner and Rector's — The Kidney. Saunders, Philadelphia, PA

    Google Scholar 

  30. Marild S, Hansson S, Jodal U, et al. (2004) Protective effect of breastfeeding against urinary tract infection. Acta Paediatr 93:164–168

    Article  PubMed  CAS  Google Scholar 

  31. Marshall JC, Maier RV, Jimenez M, et al. (2004) Source control in the management of severe sepsis and septic shock: an evidence-based review. Crit Care Med 32(11 Suppl):513–526

    Article  Google Scholar 

  32. Martin C, Papazian L, Perrin G, et al. (1993) Norepinephrine or dopamine for the treatment of hyperdynamic septic shock? Chest 103(6):1826–1831

    Article  PubMed  CAS  Google Scholar 

  33. McCammon KA, McCammon CF (2006) Acute pyelonephritis. In: Rakel Conn's current therapy, 58th edn. W.B. Saunders, St. Louis, MO

    Google Scholar 

  34. Millberg JA, Davis DR, Steinberg K P, et al. (1983–1993) Improved survival of patients with acute respiratory distress syndrome (ARDS). JAMA 273(4):306–309

    Article  Google Scholar 

  35. Naber KG (2006) Urogenital infections: the pivotal role of the urologist. Eur Urol 50:657–659

    Article  PubMed  Google Scholar 

  36. Naber KG, Bergman B, Bishop MC, et al. (2001) EAU guidelines for the management of urinary and male genital tract infections. Urinary Tract Infection (UTI) Working Group of the Health Care Office (HCO) of the European Association of Urology (EAU). Eur Urol 40(5):576–588

    Article  PubMed  CAS  Google Scholar 

  37. Nadler RB, Loeb S, Vardi I (2005) Contemporary management of urosepsis: updated critical care guidelines. Contemp Urol 17(7):35–39

    Google Scholar 

  38. Noble J (2001) Textbook of primary care medicine, 3rd edn. Mosby, Amsterdam, Chapter 146 (Laboratory studies and diagnostic procedures, urinary tract infections)

    Google Scholar 

  39. Norrby R (2004) Urinary tract infection. In: Goldman L, Bennett JC (eds) Cecil textbook of medicine, 22nd edn. WB Saunders, Philadelphia, PA

    Google Scholar 

  40. Paradisi F, Corti G, Mangani V (1998) Urosepsis in the critical care unit. Crit Care Clin 14(2):165–180

    Article  PubMed  CAS  Google Scholar 

  41. Patterson JE, Andriole VT (1987) Renal and perirenal abscesses. Infect Dis Clin North Am 1:907–926

    PubMed  CAS  Google Scholar 

  42. Phillips JR, Karlowicz MG (1997) Prevalence of Candida species in hospital-acquired urinary tract infections in a neonatal intensive care unit. Pediatr Infect Dis J 16:190–194

    Article  PubMed  CAS  Google Scholar 

  43. Rakel RE, Bope ET, Conn HF (2006) Conn's current therapy. Trauma to the genitourinary tract-ureteral trauma. Elsevier Saunders, Philadelphia, PA

    Google Scholar 

  44. Richards MJ, Edwards JR, Culver DH, et al. (1999) Nosocomial infections in pediatric intensive care units in the United States. National Nosocomial Infections Surveillance System. Pediatrics 103:e39

    Article  PubMed  CAS  Google Scholar 

  45. Rivers E, Nguyen B, Havstad S, et al. (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345(19):1368–1377

    Article  PubMed  CAS  Google Scholar 

  46. Sobel JD, Vazquez JA (1999) Fungal infections of the urinary tract. World J Urol 17:410–414

    Article  PubMed  CAS  Google Scholar 

  47. Sussman M, Cattell WR, Jones KV (1998) Urinary tract infection. In: Cameron S, et al. (eds) Oxford textbook of clinical nephrology, 2nd edn. Oxford University Press, New York

    Google Scholar 

  48. Sussman M, Gally DL (1999) The biology of cystitis: host and bacterial factors. Annu Rev Med 50:149–158

    Article  PubMed  CAS  Google Scholar 

  49. van den Berghe G, Wouters P, Weekers F, et al. (2001) Intensive insulin therapy in the critically ill patients. N Engl J Med 345(19):1359–1367

    Article  PubMed  Google Scholar 

  50. Vincent JL, Gerlach H (2004) Fluid resuscitation in severe sepsis and septic shock: an evidence-based review. Crit Care Med 32(11 Suppl):451–454

    Article  Google Scholar 

  51. Walsh PC, Retik AB, Vaughan ED, et al. (2002) Infections of the urinary tract. In: Cambpell's urology, 8th edn. Saunders, Philadelphia, PA

    Google Scholar 

  52. Walsh PC, Retik AB, Vaughan ED, et al. (2002) Perinatal urology, neonatal urologic emergencies. In: Campbell's Urology, 8th edn. Saunders, Philadelphia, PA

    Google Scholar 

  53. Walsh PC, Retik AB, Vaughan ED, et al. (2002) Percutanous approaches to upper urinary tract. In: Campell's urology, 8th edn. Saunders, Philadelphia, PA

    Google Scholar 

  54. Watson RS, Carcillo, JA (2005) Scope and epidemiology of pediatric sepsis. Ped Crit Care Med 6(3) Suppl:3–5

    Article  Google Scholar 

  55. Wise GJ, Kozinn PJ, Goldberg P (1982) Amphotericin B as a urologic irrigant in the management of noninvasive candiduria. J Urol 128:82–84

    PubMed  CAS  Google Scholar 

  56. Wise GJ, Talluri GS, Marella VK (1999) Fungal infections of the genitourinary system: manifestations, diagnosis, and treatment. Urol Clin North Am 26:701–718

    Article  PubMed  CAS  Google Scholar 

  57. Wiswell TE, Hachey WE (1993) Urinary tract infections and the uncircumcised state: an update. Clin Pediatr 32:130–134

    Article  CAS  Google Scholar 

  58. National Nosocomial Infections Surveillance (NNIS) System Report: data summary from January 1992 through June 2003, issued August 2003. Am J Infect Control 31:481–498

    Google Scholar 

  59. Practice parameter. The diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection. Pediatrics 1999;103(4, Part 1): 843–852

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Pediatric Nephrology, University of Kentucky Children's Hospital, 740 South Limestone Street, Lexington, KY, 40536, USA

    G. Abuazza

  2. Division of Pediatric Infectious Diseases, University of Kentucky Children's Hospital, 740 South Limestone Street, Lexington, KY, 40536, USA

    C. Nelson

Authors
  1. G. Abuazza
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  2. C. Nelson
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Editor information

Editors and Affiliations

  1. Division of Pediatric Nephrology and Renal Transplantation, Kentucky Children's Hospital University of Kentucky, 740 South Limestone Street Room J460, Lexington, KY, 40536, USA

    Stefan G. Kiessling

  2. Nephrology and Hypertension Division Medical Director, Kidney Transplantation Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA

    Jens Goebel

  3. Division of Nephrology, Harvard Medical School Children's Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115, USA

    Michael J. G. Somers

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© 2009 Springer-Verlag Berlin Heidelberg

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Abuazza, G., Nelson, C. (2009). Urosepsis. In: Kiessling, S.G., Goebel, J., Somers, M.J.G. (eds) Pediatric Nephrology in the ICU. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74425-2_11

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  • DOI: https://doi.org/10.1007/978-3-540-74425-2_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-74423-8

  • Online ISBN: 978-3-540-74425-2

  • eBook Packages: MedicineMedicine (R0)

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