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The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies pp 93–115Cite as

Adhesion, Invasion, Integrins, and Beyond

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The importance of the tumor microenvironment for tumor development and progression becomes increasingly evident. A precise and concerted interplay between both the cellular components, i.e., the cells and their mutations, and the acellular components, i.e., the tumor microenvironment, drives tumor growth and spread beyond physiological boundaries as well as promotes cellular resistance to conventional radiotherapy and chemotherapy. One of the prominent microenvironmental modulators of the sensitivity of tumor tissue and tumor-associated normal tissue to therapy is the interaction of cells with the extracellular matrix. Besides serving as structural support for the cells in a tissue, the extracellular matrix participates in the regulation of essential cell functions such as survival, proliferation, differentiation, adhesion, and migration. In this chapter, the overarching function of the tumor-related extracellular matrix is depicted and summarized with regard to the molecular, pathophysiological, and radiobiological aspects associated with tumor biology, radiation, and chemoresistance in the context of cell adhesion molecule families, their interactions with other types of cell surface receptors, and the downstream network of signal transducers.

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  1. OncoRay-Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany

    Nils Cordes MD, PhD, Stephanie Hehlgans PhD & Iris Eke MD

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  1. Nils Cordes MD, PhD
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  2. Stephanie Hehlgans PhD
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  3. Iris Eke MD
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  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Michael Molls MD

  2. Institute of Physiology and Pathophysiology, University Medical Center, Duesbergweg 6, 55099, Mainz, Germany

    Peter Vaupel MD, MA

  3. Department of Internal Medicine – Oncology, Nordlandssykehuset HF Hospital, 8092, Bodø, Norway

    Carsten Nieder MD

  4. Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, 401 College Street, 980058, 23298-0058, Richmond, VA, USA

    Mitchell S. Anscher MD, FACR, FACRO

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Cordes, N., Hehlgans, S., Eke, I. (2009). Adhesion, Invasion, Integrins, and Beyond. In: Molls, M., Vaupel, P., Nieder, C., Anscher, M. (eds) The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74386-6_5

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