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Evolution and Function of Processosome, the Complex That Assembles Ribosomes in Eukaryotes: Clues from Comparative Sequence Analysis

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Practical Bioinformatics

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 15))

An assembly of functioning ribosomes starts with the biosynthesis of ribosomal RNAs and proteins. In all living species, polycistronic pre-ribosomal RNA (pre-rRNA) is processed to mature rRNAs and is covalently modified at multiple positions, with the aid of specific protein enzymes and small nucleolar guide RNAs (snoRNAs). There are more than 40 known types of covalent rRNA modifications, the two most common ones being pseudouridylation and methylation (Crain et al. 2003). Ribosomal proteins, some of which are also covalently modified, are then assembled into mature ribosome subunits with rRNA. In eukaryotic cells, cytoplasmically synthesized ribosomal proteins have to be imported into the nucleus, and the assembled ribosomes are exported from the nucleus back into the cytoplasm.

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Authors and Affiliations

  1. Stowers Institute for Medical Research, 1000 E 50th St, 64110, Kansas City, MI, USA

    Arcady Mushegian

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  1. Arcady Mushegian
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  1. International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109, Warsaw, Poland

    Janusz M. Bujnicki

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Mushegian, A. (2008). Evolution and Function of Processosome, the Complex That Assembles Ribosomes in Eukaryotes: Clues from Comparative Sequence Analysis. In: Bujnicki, J.M. (eds) Practical Bioinformatics. Nucleic Acids and Molecular Biology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74268-5_9

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  • DOI: https://doi.org/10.1007/978-3-540-74268-5_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-74267-8

  • Online ISBN: 978-3-540-74268-5

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