Abstract
Protein degradation by the proteasome is one of the key steps in cell biology and in immune biology. For degradation a mathematical model can be based on a binomial distribution, where the wanted cleavage probabilities are characterized by a minimization problem. The proposed method analyzes the singular values of the Jacobian, thus giving a significant parameter reduction. The computation time is 50 fold reduced compared to the unreduced model, which in practice means hours instead of days for a run. The implementation is based on MATLAB.
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Stolte, T., Rentrop, P. (2008). A Singular Value Based Probability Algorithm for Protein Cleavage. In: Breitner, M.H., Denk, G., Rentrop, P. (eds) From Nano to Space. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74238-8_9
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DOI: https://doi.org/10.1007/978-3-540-74238-8_9
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