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Self-Sensing Cantilever Sensor for Bioscience

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Applied Scanning Probe Methods VIII

Part of the book series: Nano Science and Technolgy ((NANO))

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Abstract

A simple and high-sensitivity detection system is desired in the fields of biotechnology and medical science. In order to develop the system, one of the techniques is the use of a microcantilever mass sensor using a harmonic vibration with a resonance frequency. In this chapter, we describe a harmonic vibration-type self-sensing cantilever sensor in bioscience applications. Firstly, we introduce the cantilever mass sensor and its vibrations using theoretical analysis of cantilever motion and finite element method simulation. Then, we explain details of the selfsensing system using a piezoresistive cantilever. Finally, we demonstrate two application studies to achieve femtogram sensitivity, one for water molecule detection in air and the other for the biomolecular reaction between an antigen and an antibody in water.

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Author information

Authors and Affiliations

  1. Department of Production Science and Technology, Gunma University, 1-5-1 Tenjin-cho, 376-8515, Kiryu, Gunma, Japan

    Hayato Sone & Sumio Hosaka

Authors
  1. Hayato Sone
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  2. Sumio Hosaka
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Editor information

Editors and Affiliations

  1. Nanotribology Laboratory for Information Storage and MEMS/NEMS (NLIM), The Ohio State University, W390 Scott Laboratory, 201W. 19th Avenue, 43210-1142, Columbus, Ohio, USA

    Bharat Bhushan

  2. Institute of Physics, FB 16, University of Münster, Wilhelm-Klemm-Str. 10, 48149, Münster, Germany

    Harald Fuchs

  3. Advanced Institute of Science & Technology, School of Materials Science, 923-1292, Ishikawa, Japan

    Masahiko Tomitori

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Sone, H., Hosaka, S. (2008). Self-Sensing Cantilever Sensor for Bioscience. In: Bhushan, B., Fuchs, H., Tomitori, M. (eds) Applied Scanning Probe Methods VIII. Nano Science and Technolgy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74080-3_6

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