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Genome Mapping and Genomics in Animal-Associated Microbes pp 191–231Cite as

Theileria

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Theileria are tick-transmitted, intracellular protozoan parasites infecting leukocytes and erythrocytes of wild and domestic large and small ruminants. Certain species cause rapidly fatal diseases of livestock in Africa and Asia. The schizont stage of Theileria induces reversible “immortalization” of infected leukocytes and parasite, and host cell cycles are closely synchronized. The recent determination of genome sequences for the most economically important species T. parva and T. annulata will facilitate systematic investigation of the unique biology. The compact 8.3-8.35 megabase genomes are predicted to contain approximately 4,000 genes. In silico analysis indicates that Theileria cell cycle and transcriptional regulatory proteins are distinct from those of other eukaryotes, but do not reveal numerous candidate “oncogenes.” Whole genome transcriptome analyses of RNA expression in the T. parva schizont stage using MPSS detected transcripts from a high percentage of genes. A subset of highly expressed proteins, with heat shock proteins prominent, was identified using proteomics. Significant modulation of transcription in host monocytes following T. annulata infection has been observed using a bovine macrophage microarray. Molecular markers derived from Theileria genomes have provided insights into parasite molecular epidemiology and population genetics. The genomes have also been exploited to identify candidate antigens for subunit vaccine development.

Keywords

  • Salivary Gland
  • Small Ruminant
  • Life Cycle Stage
  • Massively Parallel Signature Sequencing
  • Trop Anim Health Prod

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  • Abrahamsen MS, Templeton TJ, Enomoto S, Abrahante JE, Zhu G, Lancto CA, Deng M, Liu C, Widmer G, Tzipori S, Buck GA, Xu P, Bankier AT, Dear PH, Konfortov BA, Spriggs HF, Iyer L, Anantharaman V, Aravind L, Kapur V (2004) Complete genome sequence of the apicomplexan, Crypt-osporidium parvum. Science 304:441–445

    PubMed  CAS  Google Scholar 

  • Aktas M, Altay K, Dumanli N (2006) PCR-based detection of Theileria ovis in Rhipicephalus bursa adult ticks. Vet Para-sitol 140:259–263

    CAS  Google Scholar 

  • Allsopp B, Carrington M, Baylis H, Sohal S, Dolan T, Iams K (1989) Improved characterization of Theileria parva isolates using the polymerase chain reaction and oligonucle-otide probes. Mol Biochem Parasitol 35:137–147

    PubMed  CAS  Google Scholar 

  • Allsopp BA, Baylis HA, Allsopp MT, Cavalier-Smith T, Bishop RP, Carrington DM, Sohanpal B, Spooner P (1993) Discrimination between six species of Theileria using oligo-nucleotide probes which detect small subunit ribosomal RNA sequences. Parasitology 107:157–165

    PubMed  CAS  Google Scholar 

  • Allsopp MT, Cavalier-Smith T, De Waal DT, Allsopp BA (1994) Phylogeny and evolution of the piroplasms. Parasitology 108:147–152

    PubMed  CAS  Google Scholar 

  • Altay K, Dumanli N, Aktas M (2007) Molecular identification, genetic diversity and distribution of Theileria and Babe-sia species infecting small ruminants. Ve t Parasitol 147:161–165

    PubMed  CAS  Google Scholar 

  • Anderson NG, Anderson NL (1978) Analytical techniques for cell fractions. XXI. Two-dimensional analysis of serum and tissue proteins: multiple isoelectric focusing. Ann Biochem 85:331–340

    CAS  Google Scholar 

  • Andrews NW, Webster P (1991) Phagolysosomal escape by intracellular pathogens. Parasitol Today 7:335–340

    PubMed  CAS  Google Scholar 

  • Awadalla P, Walliker D, Babiker H, Mackinnon M (2001) The question of Plasmodium falciparum population structure.Trends Parasitol 17:351–353

    PubMed  CAS  Google Scholar 

  • Babiker HA, Ranford-Cartwright LC, Currie D, Charlwood JD,Billingsley P, Teuscher T, Walliker D (1994) Random mating in a natural population of the malaria parasite Plas-modium falciparum. Parasitology 109:413–421

    PubMed  Google Scholar 

  • Bagby S, Kim S, Maldonado E, Tong KI, Reinberg D, Ikura M (1995) Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. Cell 82:857–867

    PubMed  CAS  Google Scholar 

  • Bakheit MA, Scholzen T, Ahmed JS, Seitzer U (2006) Molecular characterization of a Theileria lestoquardi gene encoding for immunogenic protein splice variants. Parasitol Res 100:161–170

    PubMed  CAS  Google Scholar 

  • Baldwin CL, Malu MN, Grootenhuis JG (1988) Evaluation of cytotoxic lymphocytes and their parasite strain specificity from African buffalo infected with Theileria parva. Parasite Immunol 10:393–403

    PubMed  CAS  Google Scholar 

  • Barry JD, Ginger ML, Burton P, McCulloch R (2003) Why are parasite contingency genes often associated with telom-eres? Int J Parasitol 33:29–45

    PubMed  CAS  Google Scholar 

  • Bateman A, Coin L, Durbin R, Finn RD, Hollich V, Griffiths-Jones S, Khanna A, Marshall M, Moxon S, Sonnhammer EL,Studholme DJ, Yeats C, Eddy SR (2004) The Pfam protein families database. Nucl Acids Res 32:D138–D141

    PubMed  CAS  Google Scholar 

  • Baumgartner M, Tardieux I, Ohayon H, Gounon P, Langsley G (1999) The use of nocodazole in cell cycle analysis and parasite purification from Theileria parva-infected B cells. Microb Infect 1:1181–1188

    CAS  Google Scholar 

  • Baylis HA, Sohal SK, Carrington M, Bishop R P, Allsopp BA (1991) An unusual repetitive gene family in Theileria parva which is stage-specifically transcribed. Mol Bio-chem Parasitol 49:133–142

    CAS  Google Scholar 

  • Bergman DK, Palmer MJ, Caimano MJ, Radolf JD, Wikel SK (2000) Isolation and molecular cloning of a secreted immunosuppressant protein from Dermacentor andersoni salivary gland. J Parasitol 86:516–525

    PubMed  CAS  Google Scholar 

  • Bishop R, Musoke A, Morzaria S, Sohanpal B, Gobright E (1997)Concerted evolution at a multicopy locus in the protozoan parasite ,Theileria parva: extreme divergence of potential protein-coding sequences. Mol Cell Biol 17:1666–1673

    PubMed  CAS  Google Scholar 

  • Bishop R, Morzaria S, Gobright E (1998) Linkage of two distinct AT-rich minisatellites at multiple loci in the genome of Theileria parva. Gene 216:245–254

    PubMed  CAS  Google Scholar 

  • Bishop R, Gobright E, Spooner P, Allsopp B, Sohanpal B, Collins N (2000a) Microsequence heterogeneity and expression of the LSU rRNA genes within the two single copy ribosomal transcription units of Theileria parva. Gene 257:299–305

    CAS  Google Scholar 

  • Bishop R, Gobright E, Nene V, Morzaria S, Musoke A, Sohanpal B (2000b) Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theile-ria parva telomeres. Mol Biochem Parasitol 110:359–371

    CAS  Google Scholar 

  • Bishop R, Geysen D, Spooner P, Skilton R, Nene V, Dolan T,Morzaria S (2001) Molecular and immunological characterisation of Theileria parva stocks which are components of the ‘Muguga cocktail’ used for vaccination against East Coast fever in cattle. Vet Parasitol 94:227–237

    PubMed  CAS  Google Scholar 

  • Bishop R, Geysen D, Skilton R, Odongo D, Nene V, Allsopp BA,Mbogo S, Spooner P, Morzaria S (2002) Genomic polymorphism, sexual recombination and molecular epidemiologyof Theileria parva. In: Dobbelaere DAE, Mckeever DJ (eds)Theileria. Kluwer, Boston, pp 23–40

    Google Scholar 

  • Bishop R, Musoke A, Morzaria S, Gardner M, Nene V (2004)Theileria: intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks. Parasi-tology 129:S271–S283

    Google Scholar 

  • Bishop R, Shah T, Pelle R, Hoyle D, Pearson T, Haines L, Brass A, Hulme H, Graham SP, Taracha EL, Kanga S, Lu C, Hass B, Wortman J, White O, Gardner MJ, Nene V, de Villiers EP (2005) Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage.Nucl Acids Res 33:5503–5511

    PubMed  CAS  Google Scholar 

  • Bishop R, Musoke A, Skilton R, Morzaria S, Gardner M, Nene V Theileria: life cycle stages associated with the ixodid tick vector. In: Nuttall (ed.) Ticks: biology, disease and control.Cambridge Univ Press, New York, in press

    Google Scholar 

  • Bishop RP, Sohanpal BK, Allsopp BA, Spooner PR, Dolan TT,Morzaria SP (1993) Detection of polymorphisms among Theileria parva stocks using repetitive, telomeric and ribosomal DNA probes and anti-schizont monoclonal antibodies. Parasitology 107:19–31

    PubMed  CAS  Google Scholar 

  • Bishop RP, Sohanpal BK, Morzaria SP, Dolan TT, Mwakima FN, Young AS (1994) Discrimination between Theileria parva and ,T. taurotragi in the salivary glands of Rhipi-cephalus appendiculatus ticks using oligonucleotides homologous to ribosomal RNA sequences. Parasitol Res 80:259–261

    PubMed  CAS  Google Scholar 

  • Borst P, Bitter W, McCulloch R, Van Leeuwen F, Rudenko G (1995) Antigenic variation in malaria. Cell 82:1–4

    PubMed  CAS  Google Scholar 

  • Boulter N, Hall R (1999) Immunity and vaccine development in the bovine theilerioses. Adv Parasitol 44:41–97

    PubMed  CAS  Google Scholar 

  • Brenner S, Johnson M, Bridgham J, Golda G, Lloyd DH, Johnson D, Luo S, McCurdy S, Foy M, Ewan M, Roth R, George D,Eletr S, Albrecht G, Vermaas E, Williams SR, Moon K, Bur-cham T, Pallas M, DuBridge RB, Kirchner J, Fearon K, Mao J, Corcoran K (2000) Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat Biotechnol 18:630–634

    PubMed  CAS  Google Scholar 

  • Brown CGD (1997) Dynamics and impact of tick-borne diseases of cattle. Trop Anim Health Prod 29:S1–S3

    Google Scholar 

  • Burton JL, Rosa GJM (2006) Physiological genomics special issue on animal functional genomics. Physiol Genom 28:1–4

    Google Scholar 

  • Campbell JDM, Spooner RL (1999) Macrophages behaving badly—infected cells and subversion of immune responses to Theileria annulata. Parasitol Today 15:10–16

    Google Scholar 

  • Carlton JM, Angiuoli S V, Suh BB, Kooij TW, Pertea M et al.(2002) Genome sequence and comparative analysis of themodel rodent malaria parasite Plasmodium yoelii yoelii.Nature 419:512–519

    PubMed  CAS  Google Scholar 

  • Carrington M, Allsopp B, Baylis H, Malu NM, Shochat Y, Sohal S (1995) Lymphoproliferation caused by Theileria parva and Theileria annulata. In: Boothroyd K (ed) Molecular Approaches to Parasitology. Wiley, New York, pp 43–56

    Google Scholar 

  • Cawley SE, Wirth AI, Speed TP (2001) Phat—a gene finding program for Plasmodium falciparum. Mol Biochem Parasitol 118:167–174

    PubMed  CAS  Google Scholar 

  • Chae J, Levy M, Hunt J Jr, Schlater J, Snider G, Waghela SD, Hol-man PJ, Wagner GG (1999) Theileria sp. Infections associted with bovine fatalities in the United States confirmed by small-subunit rRNA gene analyses of blood and tick samples. J Clin Microbiol 37:3037–3040

    PubMed  CAS  Google Scholar 

  • Chansiri K, Kawazub S, Kamiob T, Teradab Y, Fujisakic K,Philipped H, Sarataphane N (1999) Molecular phyloge-netic studies on Theileria parasites based on small subunit ribosomal RNA gene sequences. Vet Parasitol 83:99–105

    PubMed  CAS  Google Scholar 

  • Chin L, De Pinho RL (2000) Flipping the oncogene switch; illumination of tumor maintenance and regression. Trends Genet 16:147–150

    PubMed  CAS  Google Scholar 

  • Conrad PA, Stagg DA, Grootenhuis JG, Irvin AD, Newson J, Njamunggeh RE, Rossiter PB, Young AS (1987) Isolation of Theileria parasites from African buffalo (Syncerus caffer)and characterization with anti-schizont monoclonal antibodies. Parasitology 94:413–423

    PubMed  Google Scholar 

  • Coulson RM, Hall N, Ouzounis CA (2004) Comparative genom-ics of transcriptional control in the human malaria parasite Plasmodium falciparum. Genome Res 14:1548–1554

    PubMed  CAS  Google Scholar 

  • De Castro JJ, James AD, Minjauw B, Di Giulio GU, Permin A,Pegram RG, Chizyuka GB, Sinyangwe P (1997) Long-term studies on the economic impact of ticks on Sanga cattle in Zambia. Exp Appl Acarol 21:3–19

    PubMed  Google Scholar 

  • Dobbelaere D, Heussler V (1999) Transformation of leukocytes by Theileria parva and T.annulata . Annu Rev Microbiol 53:1–42

    PubMed  CAS  Google Scholar 

  • Dobbelaere DA, Küenzi P (2004) The strategies of the Theileriaparasite: a new twist in host-pathogen interactions. Curr Opin Immunol 16:524–530

    PubMed  CAS  Google Scholar 

  • Dobbelaere DA, Spooner PR, Barry WC, Irvin AD (1984) Monoclonal antibody neutralizes the sporozoite stage of different Theileria parva stocks. Parasite Immunol 6:361–370

    PubMed  CAS  Google Scholar 

  • Fadiel A, Anidi I, Eichenbaum KD (2005) Farm animal genomics and informatics: an update. Nucleic Acids Res 33:6308–6318

    PubMed  CAS  Google Scholar 

  • Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V,Fusco A (2001) Role of the high mobility group A proteins in human lipomas. Carcinogenesis 22:1583–1591

    PubMed  CAS  Google Scholar 

  • Galley Y, Hagens G, Glaser I, Davis W, Eichhorn M, Dobbelaere D (1997) Jun NH2 -terminal kinase is constitutively activated in T cells transfromed by the intracellular parasite Theileria parva. Proc Nat Acad Sci USA 94:5119–5124

    PubMed  CAS  Google Scholar 

  • Ganesan K, Jiang L, Rathod PK (2002) Stochastic versus stable transcriptional differences on Plasmodium falciparumDNA microarrays. Int J Parasitol 32:1543–1550

    PubMed  CAS  Google Scholar 

  • Gardner MJ, Bishop R, Shah T, de Villiers E P, Carlton JM et al (2005) Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes. Science 309:134–137

    PubMed  CAS  Google Scholar 

  • Gauer M, Mackenstedt U, Mehlhorn H, Schein E, Zapf F, Njenga E,Young A, Morzaria S (1995) DNA measurements and ploidy determination of developmental stages in the life cycles of Theileria annulata and T. parva Parasitol Res 81:565–574

    PubMed  CAS  Google Scholar 

  • Glass EJ, Coussens PM (2005) Functional genomics of host —pathogen interactions in species of veterinary importance.Vet Immunol Immunopathol 105:173–174

    Google Scholar 

  • Glass EJ, Jensen K (2007) Resistance and susceptibility to a protozoan parasite of cattle — gene expression differences in macrophages from different breeds of cattle. Vet Immunol Immunopathol 120:20–30

    PubMed  CAS  Google Scholar 

  • Glass EJ, Spooner RL (1990) Parasite-accessory cell interactions in theileriosis. Antigen presentation by Theileria annulatainfected macrophages and production of continuously growing antigen-presenting cell lines. Eur J Immunol 20:2491–2497

    PubMed  CAS  Google Scholar 

  • Glass EJ, Innes EA, Spooner RL, Brown CG (1989) Infection of bovine monocyte/macrophage populations with Theileria annulata and Theileria parva. Vet Immunol Immun-opathol 22:355–368

    CAS  Google Scholar 

  • Glass EJ, Preston PM, Springbett A, Craigmile S, Kirvar E,Wilkie G, Brown CGD (2005) Bos taurus and Bos indicus (Sahiwal) calves respond differently to infection with Theileria annulata and produce markedly different levels of acute phase proteins. Int J Parasit 35:337–347

    CAS  Google Scholar 

  • Goddeeris BM, Morrison WI (1987) The bovine autologous Theileria mixed leucocyte reaction: influence of monocytes and phenotype of the parasitized stimulator cell on proliferation and parasite specificity. Immunology 60:63–69

    PubMed  CAS  Google Scholar 

  • Goddeeris BM, Morrison WI, Toye PG, Bishop R (1990) Strain specificity of bovine Theileria parva-specific cytotoxic T cells is determined by the phenotype of the restricting class I MHC. Immunology 69:38–44

    PubMed  CAS  Google Scholar 

  • Graham SP, Pelle R, Honda Y, Mwangi DM, Tonukari NJ et al.(2006)Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes. Proc Natl Acad Sci USA 103:3286–3291

    PubMed  CAS  Google Scholar 

  • Graham SP, Honda Y, Pellé R, Mwangi DM, Glew EJ, de Villiers E P, Shah T, Bishop R, van der Bruggen P, Nene V, Taracha EL (2007) A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology. Immun Res 3:2

    Google Scholar 

  • Green RD, Qureshi MA, Long JA, Burfening PJ, Hamernik DL (2007) dentifying the future needs for long-term USDA efforts in agricultural animal genomics. Int J Biol Sci 3:185–191

    PubMed  CAS  Google Scholar 

  • Gubbels MJ, Yin H, Bai Q, Liu G, Nijman IJ, Jongejan F (2002)The phylogenetic position of theTheileria buffeli group in relation to otherTheileria species. Parasitol Res 88:S28–S32

    PubMed  Google Scholar 

  • Gunasekera AM, Patankar S, Schug J, Eisen G, Kissinger J, RoosD, Wirth DF (2004) Widespread distribution of antisense transcripts in thePlasmodium falciparum genome. Mol Biochem Parasitol 136:35–42

    PubMed  CAS  Google Scholar 

  • Gunderson JH, Sogin ML, Wollett G, Hollingdale M, de la Cruz VF, Waters AP, McCutchan TF (1987) Structurally distinct,stage-specific ribosomes occur in Plasmodium. Science 238:933–937

    PubMed  CAS  Google Scholar 

  • Hanks SK, Hunter T (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9:576–596

    PubMed  CAS  Google Scholar 

  • Hashemi-Fesharki R (1997) Tick-borne diseases of sheep and goats and their related vectors in Iran. Parassitologia 39:115–117

    PubMed  CAS  Google Scholar 

  • Hawa NJ, Latif BM, Ali SR (1981) Immunization of sheep againstTheileria hirci infection with schizonts propagated in tissue culture. Vet Parasitol 9:91–97

    PubMed  CAS  Google Scholar 

  • Heussler V (2002)Theileria survival strategies and host cell transformation. In: Dobbelaere DAE, McKeever DJ (eds) World Class Parasites. Kluwer, Dorderecht, The Netherlands, pp 69–84

    Google Scholar 

  • Heussler VT, Rottenberg S, Schwab R, Küenzi P, Fernandez PC,McKellar S, Shiels B, Chen ZJ, Orth K, Wallach D, Dobbelaere DA (2002) Hijacking of host cell IKK signalosomes by the transforming parasiteTheileria. Science 298:1033–1036

    PubMed  CAS  Google Scholar 

  • Hinterberg K, Mattei D, Wellems TE, Scherf A (1994) Interchro-mosomal exchange of a large subtelomeric segment in aPlasmodium falciparum cross. EMBO J 13:4174–4180

    PubMed  CAS  Google Scholar 

  • Honda Y, Matsubara Y, Morzaria S, Mckeever D (1998) Immu-nohistochemical detection of parasite antigens inTheileria parva-infected bovine lymphocytes. Vet Parasitol 80:137–147

    PubMed  CAS  Google Scholar 

  • Hooshmand-Rad P (1985) The use of tissue culture attenuated live vaccine forTheileria hirci. Dev Biol Stand 62:119–127

    PubMed  CAS  Google Scholar 

  • Hooshmand-Rad P, Hawa NJ (1973a) Transmission ofTheileria hirci in sheep with Hyalomma anatolicum. Trop Anim Health Prod 5:103–109

    Google Scholar 

  • Hooshmand-Rad P, Hawa NY (1973b) Malignant theileriosis of sheep and goats. Trop Anim Health Prod 5:97–102

    Google Scholar 

  • Hooshmand-Rad PH, Hawa NJ (1975) Cultivation ofTheile-ria hirci in sheep lymphoid cells. Trop Anim Health Prod 7:121–122

    Google Scholar 

  • Huang J, Mullapudi N, Sicheritz-Ponten T, Kissinger JC (2004)A first glimpse into the pattern and scale of gene transfer in Apicomplexa. Int J Parasitol 34:265–274

    PubMed  CAS  Google Scholar 

  • Hunt T (1991) Cell biology. Destruction's our delight. Nature 349:100–101

    PubMed  CAS  Google Scholar 

  • Innes EA, Millar P, Brown CG, Spooner RL (1989) The developent and specificity of cytotoxic cells in cattle immunized with autologous or allogeneicTheileria annulata-infected lymphoblastoid cell lines. Parasite Immunol 11:57–68

    PubMed  CAS  Google Scholar 

  • Irvin AD, Morrison WI (1987) Immunopathology, immunology and immunoprophylaxis of Theileria infections. In:Soulsby EJL (ed.) Immune responses in parasitic infections: immunology, immunopathology and immuno-prophylaxis. CRC, Boca Ratan, Florida, pp 223–274

    Google Scholar 

  • Irvin AD, Ocama JG, Spooner PR (1982) Cycle of bovine lym-phoblastoid cells parasitised by Theileria parva. Res Vet Sci 33:298–304

    PubMed  CAS  Google Scholar 

  • Jensen K, Speed D, Paxton E, Williams JL, Glass EJ (2006a)Construction of a normalized Bos taurus and Bos indicus macrophage-specific cDNA library. Anim Genet 37:75–77

    Google Scholar 

  • Jensen K, Talbot R, Paxton E, Waddington D, Glass EJ (2006b)Development and validation of a bovine macrophage specific cDNA microarray. BMC Genom 7:224

    Google Scholar 

  • Jensen K, de Miranda Santos IK, Glass EJ (2007) Using genomic approaches to unravel livestock (host)-tick—pathogen interactions. Trends Parasitol 23:439–444

    PubMed  CAS  Google Scholar 

  • Jensen K, Paxton E, Waddington D, Talbot R, Darghouth MA,Glass EJ (2008) Differences in the transcriptional responses induced byTheileria annulata infection in bovine mono-cytes derived from resistant and susceptible cattle breeds.Int J Parasitol 38:313–325

    PubMed  CAS  Google Scholar 

  • Jura WG, Brown CG, Perry M (1985) Comparative autoradio-graphic study of parasite-host-cell cyclical relationship in lymphoblastoid cell lines infected withTheileria annulataandTheileria parva in vitro. Vet Parasitol 18:339–348

    PubMed  CAS  Google Scholar 

  • Katzer F, Ngugi D, Oura C, Bishop RP, Taracha EL, Walker AR,McKeever DJ (2006) Extensive genotypic diversity in a recombining population of the apicomplexan parasiteTheileria parva. Infect Immun 74:5456–5464

    PubMed  CAS  Google Scholar 

  • Labuda M, Trimnell AR, Licková M, Kazimírová M, Davies GM,Lissina O, Hails RS, Nuttall PA (2006) An antivector vaccine protects against a lethal vector-borne pathogen. PLoS Pathog 2:e27

    PubMed  Google Scholar 

  • Lambson B, Nene V, Obura M, Shah T, Pandit P, Ole-Moiyoi O,Delroux K, Welburn S, Skilton R, de Villiers E, Bishop R(2005) Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells. Insect Mol Biol 14:403–414

    PubMed  CAS  Google Scholar 

  • Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, Haynes JD,De La Vega P, Holder AA, Batalov S, Carucci DJ, Winzeler EA (2003) Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 301:1503–1508

    Google Scholar 

  • Leemans I, Hooshmand-Rad P, Uggla A (1997) The indirect fluorescent antibody test based on schizont antigen for study of the sheep parasiteTheileria lestoquardi. Ve t Para-sitol 69:9–18

    CAS  Google Scholar 

  • Li Y, Luo J, Liu Z, Guan G, Gao J, Ma M, Dang Z, Liu A, Ren Q,Lu B, Liu J, Zhao H, Li J, Liu G, Bai Q, Yin H (2007) Experimental transmission ofTheileria sp. (China 1) infective for small ruminants byHaemaphysalis longicornis andHaemaphysalis qinghaiensis. Parasitol Res 101:533–538

    PubMed  Google Scholar 

  • McCutchan TF, de la Cruz VF, Lal AA, Gunderson JH, Elwood HJ, Sogin ML (1988) Primary sequences of two small sub-unit ribosomal RNA genes fromPlasmodium falciparum.Mol Biochem Parasitol 28:63–68

    PubMed  CAS  Google Scholar 

  • McGuire K, Glass EJ (2005) The expanding role of microarrays in the investigation of macrophage responses to pathogens. Vet Immunol Immunopathol 105:259–275

    PubMed  CAS  Google Scholar 

  • McGuire K, Manuja A, Russell GC, Springbett A, Craigmile SC,Nichani AK, Malhotra DV, Glass EJ (2004) Quantitative analysis of pro-inflammatory cytokine mRNA expression inTheileria annulata-infected cell lines derived from resistant and susceptible cattle. Vet Immunol Immunopathol 99:87–98

    PubMed  CAS  Google Scholar 

  • McKeever DJ, Morrison WI (1994) Immunity to a parasite that transforms T lymphocytes. Curr Opin Immunol 6:564–567

    PubMed  CAS  Google Scholar 

  • McKeever DJ, Taracha EL, Innes EL, MacHugh ND, Awino E,Goddeeris BM, Morrison WI (1994) Adoptive transfer of immunity toTheileria parva in the CD8+ fraction of responding efferent lymph. Proc Natl Acad Sci USA 91:1959–1963

    PubMed  CAS  Google Scholar 

  • Mehlhorn H, Schein E (1998) Redescription of Babesia equi Laveran, 1901 asTheileria equi. Parasitol Res 84:467–475

    PubMed  CAS  Google Scholar 

  • Miranda J, Bakheit MA, Liu Z, Yin H, Mu Y, Guo S, Beyer D,Oliva A, Ahmed JS, Seitzer U (2006) Development of a recombinant indirect ELISA for the diagnosis ofTheileria sp. (China) infection in small ruminants. Parasitol Res 98:561–567

    PubMed  CAS  Google Scholar 

  • Mooi WJ, Peeper DS (2006) Oncogene-induced cell senescence-halting on the road to cancer. N Eng J Med 355:1037–1046

    CAS  Google Scholar 

  • Morrison WI, Goddeeris BM, Teale AJ, Groocock CM, Kemp SJ, Stagg DA (1987) Cytotoxic T-cells elicited in cattle challenged withTheileria parva (Muguga): evidence for restriction by class I MHC determinants and parasite strain specificity. Parasite Immunol 9:563–578

    PubMed  CAS  Google Scholar 

  • Morrissette NS, Sibley LD (2002) Cytoskeleton of apicompl-exan parasites. Microbiol Mol Biol Rev 66:21–38

    PubMed  Google Scholar 

  • Morzaria S P, Young JR (1992) Restriction mapping of the genome of the protozoan parasiteTheileria parva. P ro c Natl Acad Sci USA 89:5241–5245

    CAS  Google Scholar 

  • Mukhebi AW, Perry BD (1992) Economic implications of the control of East Coast fever in eastern, central and southern Africa. 20–23 July 1992, Kadona, Zimbabwe. ILCA (International Livestock Centre for Africa), Addis Ababa, Ethiopia, pp 107–112

    Google Scholar 

  • Musoke A, Morzaria S, Nkonge C, Jones E, Nene V (1992) A recombinant sporozoite surface antigen ofTheileria parva induces protection in cattle. Proc Natl Acad Sci USA 89:514–518

    PubMed  CAS  Google Scholar 

  • Musoke A, Rowlands J, Nene V, Nyanjui J, Katende J, Spooner P, Mwaura S, Odongo D, Nkonge C, Mbogo S, Bishop R,Morzaria S (2005) Subunit vaccines based on the p67 major surface protein ofTheileria parva sporozoites reduce severity of infection derived from field tick challenge. Vaccine 23:3084–3095

    PubMed  CAS  Google Scholar 

  • Musoke AJ, Nantulya VM, Rurangirwa FR, Buscher G (1984) Evidence for a common protective antigenic determinant on sporozoites of severalTheileria parva strains. Immunology 52:231–238

    PubMed  CAS  Google Scholar 

  • Nacer A, Berry L, Slomianny C, Mattei D (2001) Plasmodium falciparum signal sequences: simply sequences or special signals? Int J Parasitol 31:1371–1379

    PubMed  CAS  Google Scholar 

  • Nagore D, Garcia-Sanmartin J, Garcia-Perez AL, Juste RA, Hurtado A (2004) Identification, genetic diversity and prevalence ofTheileria andBabesia species in a sheep population from Northern Spain. Int J Parasitol 34:1059–1067

    PubMed  CAS  Google Scholar 

  • Neitz WO (1953) Aureomycin inTheileria parva infection.Nature 171:34–35

    PubMed  CAS  Google Scholar 

  • Neitz WO (1972) The experimental transmission ofTheileria ovis byRhipicephalus evertsi mimeticus andR. Bursa.Onderstepoort J Ve t Res 39:83–86

    CAS  Google Scholar 

  • Nene V, Bishop R, Morzaria S, Gardner MJ, Sugimoto C,ole-MoiYoi OK, Fraser CM, Irvin A (2000)Theileria parvagenomics reveals an atypical apicomplexan genome. Int J Parasitol 30:465–474

    PubMed  CAS  Google Scholar 

  • Nene V, Lee D, Kang'a S, Skilton R, Shah T, de Villiers E, Mwaura S, Taylor D, Quackenbush J, Bishop R (2004) Genes transcribed in the salivary glands of female Rhipicephalus appendiculatus ticks infected withTheileria parva. Insect Biochem Mol Biol 34:1117–1128

    PubMed  Google Scholar 

  • Nesvizhskii AI, Aebersold R (2005) Interpretation of shotgun proteomic data: the protein inference problem. Mol Cell Proteomics 4:1419–1440

    PubMed  CAS  Google Scholar 

  • Ngumi PN, Lesan AC, Williamson SM, Awich JR, Morzaria SP, Dolan TT, Shaw MK, Young AS (1994) Isolation and preliminary characterisation of a previously unidentified Theileria parasite of cattle in Kenya. Res Vet Sci 57:1–9

    PubMed  CAS  Google Scholar 

  • Norval RA, Lawrence JA, Young AS, Perry BD, Dolan TT, Scott J (1991) Theileria parva: influence of vector, parasite and host relationships on the epidemiology of theileriosis in southern Africa. Parasitology 102:347–356

    PubMed  Google Scholar 

  • Norval RAI, Perry BD, Young AS (1992) The Epidemiology of Theileriosis in Africa. Academic Press, London, UK, p 481

    Google Scholar 

  • Odongo DO, Oura CA, Spooner PR, Kiara H, Mburu D, Hanotte OH, Bishop RP (2006) Linkage disequilibrium between alleles at highly polymorphic mini- and micro-satellite loci of Theileria parva isolated from cattle in three regions of Kenya. Int J Parasitol 36:937–946

    PubMed  CAS  Google Scholar 

  • Osman SA, Al Gaabary MH (2007) Clinical, haematological and therapeutic studies on tropical theileriosis in water buffaloes (Bubalus bubalis) in Egypt. Vet Parasitol 146:337–340

    PubMed  Google Scholar 

  • Oura CA, Odongo DO, Lubega GW, Spooner PR, Tait A, Bishop RP (2003) A panel of microsatellite and minisatellite markers for the characterisation of field isolates of Theile-ria parva. Int J Parasitol 33:1641–1653

    PubMed  CAS  Google Scholar 

  • Oura CA, Bishop RP, Wampande EM, Lubega GW, Tait A (2004a) Application of a reverse line blot assay to the study of haemoparasites in cattle in Uganda. Int J Parasitol 34:603–613

    CAS  Google Scholar 

  • Oura CA, Bishop R, Wampande EM, Lubega GW, Tait A (2004b)The persistence of component Theileria parva stocks in cattle immunized with the ‘Muguga cocktail’ live vaccine against East Coast fever in Uganda. Parasitology 129:27–42

    CAS  Google Scholar 

  • Oura CA, Asiimwe BB, Weir W, Lubega GW, Tait A (2005) Population genetic analysis and sub-structuring of Theileria parva in Uganda. Mol Biochem Parasitol 140:229–239

    PubMed  CAS  Google Scholar 

  • Oura CA, Bishop R, Asiimwe BB, Spooner P, Lubega GW, Tait A (2007) Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field. Parasitology 134:1205–1213

    PubMed  CAS  Google Scholar 

  • Pain A, Renauld H, Berriman M, Murphy L, Yeats CA et al (2005)Genome of the host-cell transforming parasite Theileria annulata compared with T. parva. Science 309:131–133

    PubMed  CAS  Google Scholar 

  • Paul RE, Day KP (1998) Mating patterns of Plasmodium falci-parum. Parasitol Today 14:197–202

    PubMed  CAS  Google Scholar 

  • Paul RE, Packer MJ, Walmsley M, Lagog M, Ranford-Cart-wright LC, Paru R, Day KP (1995) Mating patterns in malaria parasite populations of Papua New Guinea. Science 269:1709–1711

    PubMed  CAS  Google Scholar 

  • Preston PM, Hall FR, Glass EJ, Campbell JD, Darghouth MA,Ahmed JS, Shiels BR, Spooner RL, Jongejan F, Brown CG (1999) Innate and adaptive immune responses co-operate to protect cattle against Theileria annulata. Parasitol Today 15:268–274

    PubMed  CAS  Google Scholar 

  • Radley DE (1981) Infection and treatment method of immunization. In: Irvin AD, Cunningham, MP and Young, AS (eds) Advances in the Control of Theileriosis. Martinus Nijhoff, Hague, The Netherlands, pp 227–237

    Google Scholar 

  • Rechsteiner M, Rogers SW (1996) PEST sequences and regulation by proteolysis. Trends Biochem Sci 21:267–271

    PubMed  CAS  Google Scholar 

  • Reeves R (2001) Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277:63–81

    PubMed  CAS  Google Scholar 

  • Reinartz J, Bruyns E, Lin JZ, Burcham T, Brenner S, Bowen B,Kramer M, Woychik R (2002) Massively parallel signature sequencing (MPSS) as a tool for in-depth quantitative gene expression profiling in all organisms. Brief Funct Genomic Proteomic 1:95–104

    PubMed  CAS  Google Scholar 

  • Sager HDW, Dobbelaere DA, Jungi TW (1997) Macrophage-parasite relationship in theileriosis. Reversible phenotypic and functional dedifferentiation of macrophages infected with Theileria annulata. J Leukoc Biol 61:459–468

    PubMed  CAS  Google Scholar 

  • Salih DA, ElHussein AM, Hayat M, Taha KM (2003) Survey of Theileria lestoquardi antibodies among Sudanese sheep. Vet Parasitol 111:361–367

    PubMed  CAS  Google Scholar 

  • Salih DA, El Hussein AM, Seitzer U, Ahmed JS (2007) Epide-miological studies on tick-borne diseases of cattle in Central Equatoria State, Southern Sudan. Parasitol Res 101:1035–1044

    PubMed  CAS  Google Scholar 

  • Salzberg SL, Pertea M, Delcher AL, Gardner MJ, Tettelin H (1999) Interpolated Markov models for eukaryotic gene finding. Genomics 59:24–31

    PubMed  CAS  Google Scholar 

  • Schneider I, Haller D, Seitzer U, Beyer D, Ahmed JS (2004)Molecular genetic characterization and subcellular localization of a putative Theileria annulata membrane protein. Parasitol Res 94:405–415

    PubMed  Google Scholar 

  • Schnittger L, Hong Y, Jianxun L, Ludwig W, Shayan P, Rah-bari S, Voss-Holtmann A, Ahmed JS (2000) Phylogenetic analysis by rRNA comparison of the highly pathogenic sheep-infecting parasites Theileria lestoquardi and a Theileria species identified in China. Ann NY Acad Sci 916:271–275

    PubMed  CAS  Google Scholar 

  • Schnittger L, Yin H, Gubbels MJ, Beyer D, Niemann S, Jongejan F, Ahmed JS (2003) Phylogeny of sheep and goat Theileria and Babesia parasites. Parasitol Res 91:398–406

    PubMed  Google Scholar 

  • Schulman BA, Lindstrom DL, Harlow E (1998) Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci USA 95:10453–10458

    PubMed  CAS  Google Scholar 

  • Shaw MK (1997) The same but different: the biology of Theileria sporozoite entry into bovine cells. Int J Parasitol 27:457–474

    PubMed  CAS  Google Scholar 

  • Shaw MK (2002) Theileria development and host cell invasion.In: Dobbelaere DAE, McKeever DJ (eds) World Class Parasites, Kluwer, Boston, London, UK, pp 1–22

    Google Scholar 

  • Shaw MK (2003) Cell invasion by Theileria sporozoites. Trends Parasitol 19:2–6

    PubMed  Google Scholar 

  • Shaw MK, Tilney LG (1992) How individual cells develop from a syncytium: merogony in Theileria parva (Apicomplexa).J Cell Sci 101:109–123

    PubMed  Google Scholar 

  • Shaw MK, Tilney LG (1995) The entry of Theileria parva mero-zoites into bovine erythrocytes occurs by a process similar to sporozoite invasion of lymphocytes. Parasitology 111:455–461

    PubMed  Google Scholar 

  • Shaw MK, Tilney LG, Musoke AJ (1991) The entry of Theileria parva sporozoites into bovine lymphocytes: evidence for MHC class I involvement. J Cell Biol 113:87–101

    PubMed  CAS  Google Scholar 

  • Shaw MK, Tilney LG, McKeever DJ (1993) Tick salivary gland extract and interleukin-2 stimulation enhance susceptibility of lymphocytes to infection by Theileria parva sporo-zoites. Infect Immun 61:1486–1495

    PubMed  CAS  Google Scholar 

  • Shiels BR, McKellar S, Katzer F, Lyons K, Kinnaird J, Ward C,Wastling JM, Swan D (2004) A Theileria annulata DNA binding protein localized to the host cell nucleus alters the phenotype of a bovine macrophage cell line. Eukaryot Cell 3:495–505

    PubMed  CAS  Google Scholar 

  • Shiels B, Langsley G, Weir W, Pain A, McKellar S, Dobbelaere D (2006) Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes. Int J Parasitol 36:9–21

    PubMed  CAS  Google Scholar 

  • Skilton RA, Musoke AJ, Nene V, Wasawo D, Wells CW, Spooner PR, Bishop RP, Osaso J, Nkonge C, Latif A, Morzaria SP (2000) Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen. Mol Biochem Parasitol 107:309–314

    PubMed  CAS  Google Scholar 

  • Sohanpal B, Wasawo D, Bishop R (2000) Cloning of telomere-associated DNA using single-specific-primer polymerase chain reaction provides evidence for a conserved sequence directly adjacent to Theileria parva telomeric repeats.Gene 255:401–409

    PubMed  CAS  Google Scholar 

  • Sparagano OA, Spitalska E, Namavari M, Torina A, Cannella V, Caracappa S (2006) Phylogenetics of Theileria species in small ruminants. Ann NY Acad Sci USA 1081:505

    CAS  Google Scholar 

  • Stagg DA, Young AS, Leitch BL, Grootenhuis JG, Dolan TT (1983) Infection of mammalian cells with Theileria species. Parasitology 86:243–254

    PubMed  Google Scholar 

  • Steinfeld H, Gerber P, Wassenaar T, Castel V, Rosales M, de Haan C (2006) Livestock's Long Shadow — Environmental Issues and Options. FAO report

    Google Scholar 

  • Sugimoto C (1997) Economic importance of Theileriosis in Japan. Trop Anim Health Prod 29:49S

    Google Scholar 

  • Swan DG, Phillips K, Tait A, Shiels BR (1999) Evidence for localisation of a Theileria parasite AT hook DNA-binding protein to the nucleus of immortalised bovine host cells. Mol Biochem Parasitol 101:117–129

    PubMed  CAS  Google Scholar 

  • Swan DG, Stern R, McKellar S, Phillips K, Oura CA, Karagenc TI, Stadler L, Shiels BR (2001) Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-bind-ing proteins and evidence for localisation to the host cell nucleus. J Cell Sci 114:2747–2754

    PubMed  CAS  Google Scholar 

  • Tageldin MH, Zakia AM, Nagwa ZG, el Sawi SA (1992) An outbreak of theileriosis in sheep in Sudan. Trop Anim Health Prod 24:15–16

    PubMed  CAS  Google Scholar 

  • Taracha EL, Goddeeris BM, Morzaria SP, Morrison WI (1995)Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva. Infect Immun 63:1258–1262

    PubMed  CAS  Google Scholar 

  • Tatchell RJ (1987) Tick control in the context of ECF immunization. Parasitol Today 3:7–10

    PubMed  CAS  Google Scholar 

  • Taylor LH, Katzer F, Shiels BR, Welburn SC (2003) Genetic and phenotypic analysis of Tunisian Theileria annulat clones.Parasitology 126:241–252

    PubMed  CAS  Google Scholar 

  • Toye P, Nyanjui J, Goddeeris B, Musoke AJ (1996) Identification of neutralization and diagnostic epitopes on PIM, the polmorphic immunodominant molecule of Theileria parva.Infect Immun 64:1832–1838

    PubMed  CAS  Google Scholar 

  • Toye PG, Goddeeris BM, Iams K, Musoke AJ, Morrison WI (1991) Characterization of a polymorphic immunodomi-nant molecule in sporozoites and schizonts of Theileria parva. Parasite Immunol 13:49–62

    PubMed  CAS  Google Scholar 

  • Trimnell AR, Hails RS, Nuttall PA (2002) Dual action ectoparasite vaccine targeting ‘exposed’ and ‘concealed’ antigens.Vaccine 20:3560–3568

    PubMed  CAS  Google Scholar 

  • Uilenberg G (1981) Theilerial species of domestic livestock. In:Irvin AD, Cunningham MP, Young AS (eds) Advances in the Control of Theileriosis, Martinus Nijhoff, The Hague,The Netherlands, pp 4–37

    Google Scholar 

  • Vanhee-Brossollet C, Vaquero C (1998) Do natural antisense transcripts make sense in eukaryotes? Gene 211:1–9

    PubMed  CAS  Google Scholar 

  • Vega-Palas MA, Martin-Figueroa E, Florencio FJ (2000) Telo-meric silencing of a natural subtelomeric gene. Mol Gen Genet 263:287–291

    PubMed  CAS  Google Scholar 

  • Watanabe M, Kikawada T, Minagawa N, Yukuhiro F, Okuda T (2002) Mechanism allowing an insect to survive complete dehydration and extreme temperatures. J Exp Biol 205:2799–2802

    PubMed  CAS  Google Scholar 

  • Weir W, Ben-Miled L, Karagenç T, Katzer F, Darghouth M, Shiels B, Tait A (2007) Genetic exchange and sub-structuring in Theileria annulata populations. Mol Biochem Parasitol 154:170–180

    PubMed  CAS  Google Scholar 

  • Willadsen P (2004) Anti-tick vaccines. Parasitology 129:S367–S387

    PubMed  CAS  Google Scholar 

  • Wirth DF (2002) Biological revelations. Nature 419:495–496

    PubMed  CAS  Google Scholar 

  • Womack JE (2005) Advances in livestock genomics: opening the barn door. Genom Res 15:1699–1705

    CAS  Google Scholar 

  • Wood LJ, Maher JF, Bunton TE, Resar LMS (2000) The onco-genic properties of the HMG-I gene family. Cancer Res 60:4256–4261

    PubMed  CAS  Google Scholar 

  • Wu CL, Kirley SD, Xiao H, Chuang Y, Chung DC, Zukerberg LR (2001) Cables enhances cdk2 tyrosine 15 phospho-rylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. Cancer Res 61:7325–7332

    PubMed  CAS  Google Scholar 

  • Yin H, Liu G, Luo J, Guan G, Ma M, Ahmed J, Bai Q (2003) Observation on the schizont stage of an unidentified Theileria sp. in experimentally infected sheep. Parasitol Res 91:34–39

    PubMed  Google Scholar 

  • Yin H, Luo J, Guan G, Gao Y, Lu B, Zhang Q, Ma M, Lu W, Lu C, Yuan Z, Guo S, Wang B, Du H, Schnittger L, Ahmed J,Jongejan F (2002) Transmission of an unidentified Theileria species to small ruminants by Haemaphysalis qinghaiensis ticks collected in the field. Parasitol Res 88:S25–S27

    PubMed  Google Scholar 

  • Yin H, Schnittger L, Luo J, Seitzer U, Ahmed JS (2007) Ovine theileriosis in China: a new look at an old story. Parasitol Res 101(S2):S191–S195

    PubMed  Google Scholar 

  • Zuckerberg LR, Patrick GN, Nikolic M, Humbert S, Wu CL,Lanier LM, Gertler FB, Vidal M, van Etten RA, Tsai LH (2000) Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite out growth. Neuron 26:633–646

    Google Scholar 

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Authors and Affiliations

  1. The International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi, 00100, Kenya

    Richard P. Bishop, David O. Odongo, Simon P. Graham & Etienne P. de Villiers

  2. Department of Biochemistry, Imperial College, London, South Kensington, SW7 2AZ, UK

    David J. Mann

  3. Department of Biochemistry and Microbiology Petch Building, University of Victoria, Victoria, British Columbia, V8W 3P6, Canada

    Terry W. Pearson & Lee R. Haines

  4. Department of Veterinary Science, University of Hokkaido, Sapporo, Japan

    Chihiro Sugimoto

  5. Present address: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK

    Lee R. Haines

  6. The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin Biocentre, Roslin, Midlothian, EH25 9PS, UK

    Elizabeth Glass & Kirsty Jensen

  7. Division of Veterinary Infection Biology and Immunology, Research Center Borstel, Parkallee 22, Borstel, 23845, Germany

    Ulrike Seitzer & Jabbar S. Ahmed

  8. Present address: Virology Department, Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey, New Haw, KT15 3NB, United Kingdom

    Simon P. Graham

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  1. Institute for Genome Sciences and Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, 21021, USA

    Vishvanath Nene

  2. Department of Genetics & Biochemistry, Clemson University, 111 Jordan Hall, Clemson, SC, 29634, USA

    Chittaranjan Kole

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Bishop, R.P. et al. (2009). Theileria. In: Nene, V., Kole, C. (eds) Genome Mapping and Genomics in Animal-Associated Microbes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74042-1_6

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