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NLRs: a Cytosolic Armory of Microbial Sensors Linked to Human Diseases

  • Mathias Chamaillard
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 21)

In mammals, a tissue-specific set of Nod-like receptors (NLRs) enables collectively a swift and differential cytosolic detection of evolutionary distant microbial- and/or danger-associated molecular patterns from the extracellular and intracellular microenvironment. Repressing and de-repressing this surveil-lance machinery contribute to vital immune homeostasis and protective responses within specific tissues. Conversely, defective biology of NLR signaling pathways drives the development of recurrent infectious and/or inflammatory diseases by failing to mount barrier functions, to instruct the adaptive immune response and/or to ignore self and non-self antigens. Better decoding of microbial shedding and immune escape strategies will provide clues for the development of rational therapies striving to cure and prevent common and emerging immunopathologies in humans.

Keywords

Familial Mediterranean Fever NOD2 Mutation Muramyl Dipeptide Blau Syndrome Familial Cold Autoinflammatory Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Mathias Chamaillard
    • 1
  1. 1.INSERM U795, Physiopathology of Inflammatory Bowel DiseaseSwynghedauw HospitalLilleFrance

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