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Evaluation of the effects of topical clobetasol propionate by electrical impedance

  • Lennart Emtestam
  • Natalia Kuzmina
  • Toomas Talme
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 17)

Abstract

We have performed a study on human skin indicating that the dermal blanching induced by topical corticosteroids can be evaluated with a skin impedance spectrometer. For comparison visual scoring and laser Doppler flowmetry was used.

Keywords

Stratum Corneum Test Site Electrical Impedance Topical Corticosteroid Laser Doppler Flowmetry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McKenzie AW, Stoughton RB (1962) Method for comparing percutaneous absorption of steroids. Arch Dermatol 86: 608–610.Google Scholar
  2. 2.
    Place VA, Velazquez JG, Burdick KH (1970) Precise evaluation of topically applied corticosteroid potency. Modification of the Stoughton-McKenzie assay. Arch Dermatol 101: 531–537.CrossRefGoogle Scholar
  3. 3.
    Barry BW, Woodford R (1978) Activity and bioavailability of topical steroids. In vivo/in vitro correlations for the skin vasoconstrictor test. J Clin Pharm 3:43–65.Google Scholar
  4. 4.
    Brown PH, Teelucksingh S, Matusiewicz SP, Greening AP, Crompton GK, Edwards CR (1991) Cutaneous vasoconstrictor response to glucocorticoids in asthma. Lancet 337: 576–580.CrossRefGoogle Scholar
  5. 5.
    Smith JG, Wehr RF, Chalker DK (1976) Corticosteroid induced cutaneous atrophy and telengectasia. Arch Dermatol 112: 1115–1117.CrossRefGoogle Scholar
  6. 6.
    Nyrén M, Kuzmina N, Emtestam L (2003) Electrical impedance as a potential tool to distinguish between allergic and irritant contact dermatitis. J Am Acad Dermatol 48:394–400.CrossRefGoogle Scholar
  7. 7.
    Kuzmina N, Nyrén M, Lodén M, Edlund F, Emtestam L (2005) Effects of pre-treatment with a urea-containing emollient on nickel allergic skin reactions. Acta Derm Venereol 85: 9–12.CrossRefGoogle Scholar
  8. 8.
    Ollmar S, Nicander I (1995) Information in multi frequency measurement of intact skin. Innov Tech Biol Med 16:745–751.Google Scholar
  9. 9.
    Lukaski HC (1987) Methods for the assessment of human body composition: traditional and new. Am J Clin Nutr 46: 537–556.Google Scholar
  10. 10.
    Åberg P, Nicander I, Hansson J, Geladi P, Holmgren U, Ollmar S (2004) Skin cancer identification using multi-frequency electrical impedance – a potential screening tool. IEEE Trans Biomed Eng 51: 2097–2102.CrossRefGoogle Scholar
  11. 11.
    Åberg P, Geladi P, Nicander I, Hansson J, Holmgren U, Ollmar S (2005) Non-invasive and microinvasive electrical impedance spectra of skin cancer – a comparison between two techniques. Skin Res Technol 11:281–286.CrossRefGoogle Scholar
  12. 12.
    Nicander I, Ollmar S, Eek A, Lundh Rozell B, Emtestam L (1996) Correlation of impedance response patterns to histological findings in irritant skin reactions induced by various surfactants. Br J Dermatol 134: 221–228CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Lennart Emtestam
    • 1
  • Natalia Kuzmina
    • 1
  • Toomas Talme
    • 1
  1. 1.Department of DermatologyKarolinska University Hospital HuddingeStockholmSweden

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