Evolution of a Diagnostic Decision Support Tool Based on Electrical Impedance

  • S. Ollmar
  • I. Nicander
  • P. Åberg
  • U. Birgersson
Part of the IFMBE Proceedings book series (IFMBE, volume 17)


Among physical properties of tissues, electrical impedance stands out as a potentially useful method to monitor alterations. Our aim is to bridge the gap between idea and product by understanding and overcoming the scientific, technical, financial, clinical, regulatory, and market challenges. Micro-invasive electrodes add benefits to deep skin measurements by overcoming the stratum corneum, and data can be analyzed and classified using methods which do not suffer from a preconceived paradigm. Venture capitalists (VC) are interested in new technologies if there is a market, and if the technology is protected by patents or similar rights. A medical device also has to fulfill a number of regulatory requirements. It was found early that popular lumped parameter methods were not adequate to characterize clinically relevant alterations in skin. Simple indices were tried, which proved sufficient to quantify and classify experimentally elicited reactions in skin and oral mucosa. To improve sensitivity and specificity, more information was extracted using various multivariate techniques, and proof-ofprinciple for a skin cancer detector was achieved.


Skin Cancer Stratum Corneum Venture Capitalist Electrical Impedance Electrical Impedance Tomography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Choi MH, Kao T-J, Isaacson D, Saulnier GJ, Newell JC (2007) A reconstruction algorithm for breast cancer imaging with electrical impedance tomography in mammography geometry. IEEE Trans BME 54(4):700–710.CrossRefGoogle Scholar
  2. 2.
    Romsauerova A, McEwan A, Horesh L, Yerworth R, Bayford RH, Holder DS (2006) Multi-frequency electrical impedance tomography (EIT) of the adult human head: initial findings in brain tumours, arteriovenous malformations and chronic stroke, development of an analysis method and calibration. Physiol Meas 27: 147–161.CrossRefGoogle Scholar
  3. 3.
    Piccoli A, Patori G, Codognotto M, Paoli A (2007) Equivalence of information from single frequency v. bioimpedance spectroscopy in bodybuilders. Br J Nutri 97: 182–192.CrossRefGoogle Scholar
  4. 4.
    Min M, Ollmar S, Gersing E (2003) Electrical impedance and cardiac monitoring – technology, potential and applications. Int J Bioelectromagnetism 5:53–56.Google Scholar
  5. 5.
    Sierpowska J, Hakulinen MA, Töyräs J, Day JS, Weinans H, Kiviranta I, Jurvelin JS, Lappalainen R (2006) Interralationships between electrical properties and microstructure of human trabecular bone. Phys Med Biol 51:5289–5303.CrossRefGoogle Scholar
  6. 6.
    Fluhr JW, Gloor M, Lazzerini S, Kleesz P, Grieshaber R, Berardesca E (1999) Comparative study of five instruments measuring stratum corneum hydration (Corneometer CM 820 and CM 825, Skicon 200, Nova DPM 9003, DermaLab). Part II. In vivo. Skin Res Technol 5:171–178.CrossRefGoogle Scholar
  7. 7.
    Ollmar S, Nicander I (2005) Within and beyond the skin barrier as seen by electrical impedance. In: Bioengineering of the Skin: Water and the Stratum Corneum, 2nd ed. CRC Press, Boca Raton Fla: 335–350.Google Scholar
  8. 8.
    Åberg P, Nicander I, Ollmar S (2006) Bioimpedance as a nonivasive method for measuring changes in skin. In:Google Scholar
  9. 9.
    Handbook of Non-Invasive Methods and the Skin, 2nd ed. CRC Press Boca Raton Fla: 345–350.Google Scholar
  10. 10.
    Martinsen OG, Clausen S, Nysaether JB, Grimnes S (2007) Utilizing characteristic electrical properties of the epidermal skin layers to detect fake fingers in biometric fingerprint systems – a pilot study. IEEE Trans Biomed Eng 54:891–894.CrossRefGoogle Scholar
  11. 11.
    Nilsson R, Fallan JO, Larsson KS, Ollmar S, Sundström F (1992) Electrical impedance – a new parameter for oral mucosal irritation tests. J Materials Sc: Material in Med 3:278–282.CrossRefGoogle Scholar
  12. 12.
    Ollmar S, Emtestam L (1992) Electrical impedance applied to noninvasive detection of irritation in skin. Contact Dermatitis 27: 37–42.CrossRefGoogle Scholar
  13. 13.
    Nicander I (1998) Electrical impedance related to experimentally induced changes of human skin and oral mucosa (PhD thesis) Karolinska Institutet, Stockholm.Google Scholar
  14. 14.
    Nicander I, Ollmar S, Eek A, Lundh Rozell B, Emtestam L (1996) Correlation of impedance response patterns to histological findings in irritant skin reactions induced by various surfactants. Br J Dermatol 134: 221–228.CrossRefGoogle Scholar
  15. 15.
    Åberg P, Geladi P, Nicander I, Hansson J, Holmgren U, Ollmar S (2005) Non-invasive and microinvasive electrical impedance spectra of skin cancer – a comparison between two techniques. Skin Res Technol 11: 281–286.CrossRefGoogle Scholar
  16. 16.
    Åberg P (2004) Skin cancer as seen by electrical impedance (PhD thesis). Karolinska Institutet, Stockholm.Google Scholar
  17. 17.
    Nyrén M (2002) Skin sensitivity testing – a biophysical approach (PhD thesis) Karolinska Institutet, Stockholm.Google Scholar
  18. 18.
    Rantanen I (2003) Betaine in oral hygiene with special attention to dry and sensitive mucosa (PhD thesis). Annales Universitates Turkuensis 559, Turku, Finland.Google Scholar
  19. 19.
    Kuzmina N (2004) Biophysical aspects of contact dermatitis and its prevention (PhD thesis). Karolinska Institutet, Stockholm.Google Scholar
  20. 20.
    Grimnes S, Martinsen OG (2000) Bioimpedance and bioelectricity basics. Academic Press, London.Google Scholar
  21. 21.
    Åberg P, Geladi P, Nicander I, Ollmar S (2002) Variation of skin properties within human forearms demonstrated by non-invasive detection and multi-way analysis. Skin Res Technol 8: 194–201.CrossRefGoogle Scholar
  22. 22.
    Åberg P, Nicander I, Hansson J, Geladi P, Holmgren U, Ollmar S (2004) Skin cancer identification using multifrequency electrical impedance – a potential screening tool. IEEE Trans Biomed Eng 51: 2097–2102.CrossRefGoogle Scholar
  23. 23.
    Frank S (2003) A new model for European medical device regulation – a comparative legal analysis in the EU and the USA. Europa Law Publishing, Groningen.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • S. Ollmar
    • 1
    • 2
  • I. Nicander
    • 1
    • 2
  • P. Åberg
    • 1
    • 2
  • U. Birgersson
    • 1
    • 2
  1. 1.Medical EngineeringKarolinska InstitutetStockholmSweden
  2. 2.SciBase ABStockholmSweden

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