Why is the measured impedance of the bladder tissue different from the computational modelling results?

  • A. Keshtkar
Part of the IFMBE Proceedings book series (IFMBE, volume 17)


The electrical impedance spectroscopy technique was used to measure the electrical impedance of the human bladder tissue for differentiating pathological changes in the urothelium. Then, a numerical technique, finite element analysis (FEA) was used to model the electrical properties of this tissue in order to predict the impedance spectrum of the normal and malignant areas of this organ. After comparing the modelled data with the experimental results, it is believed that there are some factors that may affect the measurement results. Thus, the effect of inflammation, oedema, changes in the applied pressure over the probe and the distensible property of the bladder tissue were considered. Also, the current distribution inside the human bladder tissue was modelled in normal and malignant cases using the finite element analysis. This model results showed that very little of the current actually flows through the urothelium and much of the injected current flows through the connective tissue beneath the urothelium.


Impedance Spectrum Electrical Impedance Bladder Tissue Surface Fluid Human Urinary Bladder 
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  1. 1.
    .Jones, D.M., Measurement and Modelling of the Electrical Properties of Normal and Pre-cancerous Oesophageal Tissue, in Department of Medical Physics and Engineering. 2003, Sheffield University: Sheffield, PhD thesis. p. 286.Google Scholar
  2. 2.
    Walker, D.C. (2001) Modelling the electrical properties of cervical epithelium, in Department of Medical physics and clinical engineering. PhD thesis, Sheffield University: Sheffield. p. Chapter 6.Google Scholar
  3. 3.
    Brown, B.H. et al. (2000) Relation between tissue structure and imposed electrical current flow in cervical neoplasia. Lancet 355(9207):892-5.CrossRefGoogle Scholar
  4. 4.
    Walker, D.C. et al. (2002) Modelled current distribution in cervical squamous tissue. Physiol Meas 23(1):159-68.CrossRefGoogle Scholar
  5. 5.
    Walker, D.C. et al. (2000) Modelling the electrical impedivity of normal and premalignant cervical tissue. Electronics Letters 36(19):1603-1604.CrossRefGoogle Scholar
  6. 6.
    Gonzales-Correa, C.A. et al. (1999) Virtual Biopsies in Barrett’s Esophagus using an Impedance probe. Annals New York Academy of Sciences873:313-321.Google Scholar
  7. 7.
    Keshtkar, A., A. Keshtkar and R.H. Smallwood (2006) Electrical impedance spectroscopy and the diagnosis of bladder pathology. Physiol Meas 27(7):585-96.CrossRefGoogle Scholar
  8. 8.
    Keshtkar, A., Design and construction of small sized pencil probe to measure the bio-impedance. Medical Engineering and Physics, 2007(Under Press).Google Scholar
  9. 9.
    Keshtkar, A. et al. (2001) Virtual bladder biopsy by bioimpedance measurements. in XI International Conference On Electrical Bio-Impedance. Oslo, Norway: Oslo University.Google Scholar
  10. 10.
    Smallwood, R.H. et al. (2002) Electrical impedance spectroscopy (EIS) in the urinary bladder: the effect of inflammation and edema on identification of malignancy. IEEE Trans Med Imaging 21(6):708-10.CrossRefGoogle Scholar
  11. 11.
    Keshtkar A, A Keshtkar et al. (2007) Cellular morphological parameters of the human urinary bladder (malignant and normal). Int J Exp Pathol 88(3):185-90.CrossRefGoogle Scholar
  12. 12.
    Gabriel, C., S. Gabriel and E. Corthout (1996) The dielectric properties of biological tissues: I. Literature survey. Phys Med Biol 41(11):2231-49.CrossRefGoogle Scholar
  13. 13.
    Bertemes-Filho P., B.H. Brown and A.J. Wilson (2000) A comparison of modified Howland circuits as current generators with current mirror type circuits. Physiol Meas 21(1):1-6.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • A. Keshtkar
    • 1
  1. 1.Medical Physics Dep., Medical FacultyTabriz University of Medical SciencesTabrizIran, Islamic Republic of

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