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Pathologie pp 471–484Cite as

Fibrohistiozytäre Tumoren

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Zusammenfassung

Die Bezeichnung „fibrohistiozytär“ basiert auf der seinerzeitigen Annahme einer fibroblastären bzw. histiozytären Differenzierung der spindeligen bis rundlichen Tumorzellen. Gestützt wurde diese Theorie durch das oftmalige Auftreten von untermischten Entzündungszellen, Makrophagen und Riesenzellen vom Osteoklastentyp. Durch den Einsatz neuerer Untersuchungsmethoden (Elektronenmikroskopie, Immunhistochemie) hat sich jedoch herausgestellt, dass in keinen der so genannten fibrohistiozytären Tumoren eine echte histiozytische Zelldifferenzierung vorliegt. [24] Der bis heute beibehaltene Terminus „fibrohistiozytär“ umfasst daher nicht Tumoren mit gemeinsamer linienspezifischer Differenzierung, sondern eine Gruppe ätiologisch und biologisch heterogener Läsionen mit histologischen Ähnlichkeiten.

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Authors and Affiliations

  1. Institut für Pathologie, Universität Graz, Auenbrugger Platz 25, 8036, Graz, Österreich

    Alfred Beham

  2. Institut für Pathologie, Universität Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Deutschland

    Regine Schneider-Stock

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  1. Alfred Beham
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Editors and Affiliations

  1. Department of Pathological Anatomy, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spanien

    Antonio Cardesa

  2. Pathologisches Institut, Mühlenstr. 31, 45759, Recklinghausen, Deutschland

    Pierre Rudolph

  3. Dermatopathologische Gemeinschaftspraxis, Siemensstr. 6/1, 88048, Friedrichshafen, Deutschland

    Thomas Mentzel

  4. Department of Pathology HP 437, University Medical Center St. Radbound, P.O. Box 9101, 6500, Nijmegen, Niederlande

    Pieter J. Slootweg

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Beham, A., Schneider-Stock, R. (2009). Fibrohistiozytäre Tumoren. In: Cardesa, A., Rudolph, P., Mentzel, T., Slootweg, P. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72885-6_14

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  • DOI: https://doi.org/10.1007/978-3-540-72885-6_14

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