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Genetische Aspekte der Neuropsychologie psychischer Störungen

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Neuropsychologie psychischer Störungen

Zusammenfassung

Die neuropsychologischen Funktionsdefizite bei psychischen Störungen, wie sie in den anderen Beiträgen dieses Buches im Einzelnen dargestellt werden, sind nicht immer nur die diagnostisch und therapeutisch relevanten Begleiterscheinungen oder Konsequenzen von manifesten Erkrankungen. Sie können auch der Diagnose einer psychischen Störung vorausgehen, ihr Abklingen überdauern und z. T. auch bei biologisch verwandten Familienangehörigen in abgeschwächter Form vorhanden sein. Bei denjenigen psychischen Störungen, bei denen dies der Fall ist, können neuropsychologische Funktionsänderungen als primäre, möglicherweise genetisch bedingte Störungen betrachtet werden. In diesem Kapitel stellen wir dar, in welchem Ausmaß genetische Faktoren nach heutigem Wissen an der Entwicklung psychischer Störungen und neuropsychologischer Veränderungen im Rahmen dieser Störungen beteiligt sind.

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8.4. Literatur

  • Abbruzzese M, Ferri S, Scarone S (1997) The selective breakdown of frontal functions in patients with obsessive-compulsive disorder and in patients with schizophrenia: a double dissociation experimental finding. Neuropsychologia 35: 907–912

    Article  PubMed  Google Scholar 

  • Arts B, Jabben N, Krabbendam L, van Os J (2008). Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med 38: 771–785

    Article  PubMed  Google Scholar 

  • Bilder RM, Volavka J, Czobor P et al. (2002) Neurocognitive correlatesof the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 52: 701–717

    Article  PubMed  Google Scholar 

  • Bilder RM, Volavka J, Lachman HM, Grace AA (2004) The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology 29: 1943–1961

    Article  PubMed  Google Scholar 

  • Blanes T, McGuire P (1997) Heterogeneity within obsessive compulsive disorder evidence for primary and neurodevelopmental subtypes. In: Keshavan MS, Murray RM (eds) Neurodevelopment and adult psychopathology. Cambridge University Press, Cambridge, pp206–212

    Google Scholar 

  • Cannon TD, Zorrilla LE, Shtasel D et al. (1994) Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch Gen Psychiatry 51: 651–661. Die Arbeit zeigt, dass bei den Geschwistern schizophrener Patienten ein ähnliches Defizitprofil vorliegt wie bei den erkrankten Patienten selbst, wenn auch in geringerer Ausprägung.

    PubMed  Google Scholar 

  • Cardon LR, Smith SD, Fulker DW, et al. (1994) Quantitative trait locus for reading disability on chromosome6. Science 266: 276–279

    Article  PubMed  Google Scholar 

  • Chamberlain SR, Fineberg NA, Menzies LA, et al. (2007) Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. Am J Psychiatry 164:335–338.

    Article  PubMed  Google Scholar 

  • Clementz BA, Geyer MA, Braff DL (1998) Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. Am J Psychiatry 155: 1691–1694

    PubMed  Google Scholar 

  • Conklin HM, Curtis CE, Calkins ME, Iacono WG (2005) Working memory functioning in schizophrenia patients and their first-degree relatives: cognitive functioning shedding light on etiology. Neuropsychologia 43:930–942

    Article  PubMed  Google Scholar 

  • Corder EH, Saunders AM, Strittmatter WJ et al. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261: 921–923

    Article  PubMed  Google Scholar 

  • Cornblatt BA, Keilp JG (1994) Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 20: 31–46

    PubMed  Google Scholar 

  • Corral MM, Holguin SR, Cadaveira F (1999) Neuropsychological characteristics in children of alcoholics: familial density. J Stud Alcohol 60: 509–513

    PubMed  Google Scholar 

  • Cosway R, Byrne M, Clafferty R et al. (2000) Neuropsychological change in young people at high risk for schizophrenia: results from the first two neuropsychological assessments of the Edinburgh High Risk Study. Psychol Med 30: 1111–1121

    Article  PubMed  Google Scholar 

  • Curtis CE, Calkins ME, Grove WM, et al. (2001) Saccadic disinhibition in patients with acute and remitted schizophrenia and their firstdegree biological relatives. Am J Psychiatry 158: 100–106

    Article  PubMed  Google Scholar 

  • Davidson M, Reichenberg A, Rabinowitz J, et al. (1999) Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. Am J Psychiatry 156: 1328–1335

    PubMed  Google Scholar 

  • Davies N, Russell A, Jones P, Murray RM (1998) Which characteristics of schizophrenia predate psychosis? J Psychiatr Res 32: 121–131

    Article  PubMed  Google Scholar 

  • Dujardin K, Duhamel A, Becquet E, et al. (1999) Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson’s disease. J Neurol Neurosurg Psychiatry 67: 323–328

    Article  PubMed  Google Scholar 

  • Egan MF, Goldberg TE, Kolachana BS et al. (2001) Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98: 6917–6922

    Article  PubMed  Google Scholar 

  • Erlenmeyer-Kimling L (2000) Neurobehavioral deficits in offspring of schizophrenic parents: Liability indicators and predictors of illness. Am J Med Genet 97: 65–71

    Article  PubMed  Google Scholar 

  • Esslinger C, Walter H, Kirsch P et al. (2009) Neural mechanisms of a genomewide supported psychosis variant. Science, 324(5927), 605.

    Article  PubMed  Google Scholar 

  • Ettinger U, Picchioni M, Hall MH, et al. (2006) Antisaccade performance in monozygotic twins discordant for schizophrenia: the Maudsley twin study. Am J Psychiatry 163:543–545

    Article  PubMed  Google Scholar 

  • Faraone SV, Seidman LJ, Kremen WS, et al. (1995) Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J Abnorm Psychol 104: 286–304

    Article  PubMed  Google Scholar 

  • Faraone SV, Seidman LJ, Kremen WS, et al. (1999) Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study. J Abnorm Psychol 108:176–181

    Article  PubMed  Google Scholar 

  • Faraone SV, Seidman LJ, Kremen WS, et al. (2000) Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biol Psychiatry 48:120–126

    Article  PubMed  Google Scholar 

  • Frangou S, Sharma T, Alarcon G, et al. (1997) The Maudsley Family Study, II: Endogenous event-related potentials in familial schizophrenia. Schizophr Res 23: 45–53

    Article  PubMed  Google Scholar 

  • Franke P, Maier W, Hardt J, Hain C (1993) Cognitive functioning and anhedonia in subjects at risk for schizophrenia. Schizophr Res 10: 77–84

    Article  PubMed  Google Scholar 

  • Franke P, Maier W, Hardt J, et al. (1994) Attentional abilities and measures of schizotypy: their variation and covariation in schizophrenic patients, their siblings, and normal control subjects. Psychiatry Res 54: 259–272

    Article  PubMed  Google Scholar 

  • Freedman R, Coon H, Myles-Worsley M et al. (1997) Linkage of a neurophysiological deficit in schizophrenia to a chromosome15 locus. Proc Natl Acad Sci USA 94: 587–592

    Article  PubMed  Google Scholar 

  • Garland MA, Parsons OA, Nixon SJ (1993) Visual-spatial learning in nonalcoholic young adults with and those without a family history of alcoholism. J Stud Alcohol 54: 219–224

    PubMed  Google Scholar 

  • Giancola PR, Martin CS, Tarter RE, et al. (1996) Executive cognitive functioning and aggressive behavior in preadolescent boys at high risk for substance abuse/dependence. J Stud Alcohol 57: 352–359

    PubMed  Google Scholar 

  • Gillen R, Hesselbrock V (1992) Cognitive functioning, ASP, and family history of alcoholism in young men at risk for alcoholism. Alcohol Clin Exp Res 16: 206–214

    Article  PubMed  Google Scholar 

  • Gilvarry CM, Russell A, Hemsley D, Murray RM (2001) Neuropsychological performance and spectrum personality traits in the relatives of patients with schizophrenia and affective psychosis. Psychiatry Res 101: 89–100

    Article  PubMed  Google Scholar 

  • Gottesman I, Gould T (2003) The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 160: 636–649

    Article  PubMed  Google Scholar 

  • Gourovitch ML, Torrey EF, Gold JM, et al. (1999) Neuropsychological performance of monozygotic twins discordant for bipolar disorder. Biol Psychiatry 45: 639–646

    Article  PubMed  Google Scholar 

  • Gray JM, Young AW, Barker WA, et al. (1997) Impaired recognition of disgust in Huntington’s disease gene carriers. Brain 120: 2029–2038. Eine sehr gute theoriegeleitete Arbeit, die eine selektive Störung bei der Diskrimination des Ekel-Ausdrucks bei noch nicht erkrankten Huntington-Genträgern beschreibt. Die Arbeit belegt indirekt auch die Rolle der Basalganglien spezifisch für die Verabeitung Ekel-assoziierter Reize.

    Article  PubMed  Google Scholar 

  • Green MF (1996) What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 153: 321–330

    PubMed  Google Scholar 

  • Greenwood, P. M., Fossella, J. A., Parasuraman, R. (2005). Specificity of the effect of a nicotinic receptor polymorphism on individual differences in visuospatial attention. J Cogn Neurosci, 17(10), 1611–1620.

    Article  PubMed  Google Scholar 

  • Guidotti A, Auta J, Davis JM et al. (2000) Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch Gen Psychiatry 57: 1061–1069

    Article  PubMed  Google Scholar 

  • Hahn-Barma V, Deweer B, Durr A et al. (1998) Are cognitive changes the first symptoms of Huntington’s disease? A study of gene carriers. J Neurol Neurosurg Psychiatry 64: 172–177

    Article  PubMed  Google Scholar 

  • Hallmayer JF, Jablensky A, Michie P et al. (2003) Linkage analysis of candidate regions using a composite neurocognitive phenotype correlated with schizophrenia. Mol Psychiatry 8: 511–523

    Article  PubMed  Google Scholar 

  • Happe F, Briskman J, Frith U (2001) Exploring the cognitive phenotype of autism: weak “central coherence” in parents and siblings of children with autism: I. Experimental tests. J Child Psychol Psychiatry 42: 299–307. Die Autoren untersuchten einen „kognitiver Phänotyp“ des Autismus — die Neigung, stärker auf Details als auf das Ganze zu achten —bei Verwandten von autistischen Patienten. Dieser kognitive Stil führt unter bestimmten Randbedingungen (z. B. bei der Suche nach versteckten Figuren in einer Zeichnung) zu besseren Leistungen. Tatsächlich wiesen Vätern von Autisten in mehreren Aufgaben eine stärker Detail-orientierte Verarbeitung auf als Eltern dyslektischer Kinder.

    Article  PubMed  Google Scholar 

  • Harris JG, Adler LE, Young DA et al. (1996) Neuropsychological dysfunction in parents of schizophrenics. Schizophr Res 20: 253–260

    Article  PubMed  Google Scholar 

  • Harrison PJ (1999) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122: 593–624

    Article  PubMed  Google Scholar 

  • Harrison PJ, Weinberger DR (2005) Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Molecular Psychiatry 10:40–68

    Article  PubMed  Google Scholar 

  • Heinrichs RW, Zakzanis KK (1998) Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12: 426–445

    Article  PubMed  Google Scholar 

  • Helkala EL, Koivisto K, Hanninen T et al. (1996) Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study. Neurosci Lett 204: 177–180

    Article  PubMed  Google Scholar 

  • Henry JC, Amelsvoort T van, Morris RG et al. (2002) An investigation of the neuropsychological profile in adults with velo-cardio-facial syndrome (VCFS). Neuropsychologia 40: 471–478

    Article  PubMed  Google Scholar 

  • Holzman PS, Solomon CM, Levin S, Waternaux CS (1984) Pursuit eye movement dysfunctions in schizophrenia. Family evidence for specificity. Arch Gen Psychiatry 41: 136–139

    PubMed  Google Scholar 

  • Hughes C, Leboyer M, Bouvard M (1997) Executive function in parents of children with autism. Psychol Med 27: 209–220

    Article  PubMed  Google Scholar 

  • Johnson KA, Lopera F, Jones K et al. (2001) Presenilin-1-associated abnormalities in regional cerebral perfusion. Neurology 56: 1545–1551

    PubMed  Google Scholar 

  • Joober R, Gauthier J, Lal S et al. (2002) Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test. Arch Gen Psychiatry 59: 662–663

    Article  PubMed  Google Scholar 

  • Keri S, Kelemen O, Benedek G, Janka Z (2001) Different trait markers for schizophrenia and bipolar disorder: a neurocognitive approach. Psychol Med 31: 915–922

    Article  PubMed  Google Scholar 

  • Kis B, Heberlein I, Hagenah J, Jacobs H et al. (2000) Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson’s disease. J Neurol Neurosurg Psychiatry 69: 838

    Article  PubMed  Google Scholar 

  • Kremen WS, Seidman LJ, Pepple JR, et al. (1994) Neuropsychological risk indicators for schizophrenia: a review of family studies. Schizophr Bull 20: 103–119

    PubMed  Google Scholar 

  • Kremen WS, Faraone SV, Seidman LJ, et al. (1998) Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probands. Psychiatry Res 79: 227–240

    Article  PubMed  Google Scholar 

  • La Rue A, O’Hara R, Matsuyama SS, Jarvik LF (1995) Cognitive changes in young-old adults: effect of family history of dementia. J Clin Exp Neuropsychol 17: 65–70

    Article  PubMed  Google Scholar 

  • Lautenschlager N, Kurz A, Muller U (1999) Erbliche Ursachen und Risikofaktoren der Alzheimer-Krankheit. Nervenarzt 70: 195–205

    Article  PubMed  Google Scholar 

  • Leboyer M, Bellivier F, Nosten-Bertrand M, et al. (1998) Psychiatric genetics: search for phenotypes. Trends Neurosci 21: 102–105

    Article  PubMed  Google Scholar 

  • Lencz T, Smith CW, McLaughlin D, et al. (2005) Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biol Psychiatry 59:863–871.

    Article  PubMed  Google Scholar 

  • Maier W (1998) Genetische Faktoren. In: Baumann U, Perrez M (Hrsg) Lehrbuch Klinische Psychologie — Psychotherapie. Huber, Bern. Ein guter überblick über die Methoden und Ergebnisse genetisch-epidemiologischer und molekulargenetischer Studien von psychischen Erkrankungen.

    Google Scholar 

  • Maier W, Propping P (1991) Die familiäre Häufung psychischer Störungen und die Konsequenzen für die psychiatrische Diagnostik. Nervenarzt 62: 398–407

    PubMed  Google Scholar 

  • Malhotra AK, Kestler LJ, Mazzanti C, et al. (2002) A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 159: 652–654

    Article  PubMed  Google Scholar 

  • Markett, S. A., Montag, C., Reuter, M. (2009). The Association between Dopamine DRD2 Polymorphisms and Working Memory Capacity Is Modulated by a Functional Polymorphism on the Nicotinic Receptor Gene CHRNA4. J Cogn Neurosci Oct 5 [Epub ahead of print].

    Google Scholar 

  • Matsushita S, Kato M, Muramatsu T, Higuchi S (2000) Alcohol and aldehyde dehydrogenase genotypes in Korsakoff syndrome. Alcohol Clin Exp Res 24: 337–340

    Article  PubMed  Google Scholar 

  • McGuffin P, Riley B, Plomin R (2001) Genomics and behavior: Toward behavioral genomics. Science 291: 1232–1249

    Article  PubMed  Google Scholar 

  • Meyer-Lindenberg A, Weinberger D (2007) Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience 7:818–827

    Article  Google Scholar 

  • Michie PT, Innes-Brown H, Todd J, Jablensky AV (2002) Duration mismatch negativity in biological relatives of patients with schizophrenia spectrum disorders. Biol Psychiatry 52: 749–758

    Article  PubMed  Google Scholar 

  • Mondadori CR, de Quervain DJ, Buchmann A et al. (2007) Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers. Cereb Cortex 17:1934–1947.

    Article  PubMed  Google Scholar 

  • Montgomery EB Jr, Baker KB, Lyons K, Koller WC (1999) Abnormal performance on the PD test battery by asymptomatic first-degree relatives. Neurology 52: 757–762

    PubMed  Google Scholar 

  • Montgomery EB Jr, Lyons K, Koller WC (2000) Early detection of probable idiopathic Parkinson’s disease: II. A prospective application of a diagnostic test battery. Mov Disord 15: 474–478

    Article  PubMed  Google Scholar 

  • Moritz S, Fricke S, Wagner M, Hand I (2001) Further evidence for delayed alternation deficits in obsessive-compulsive disorder. J Nerv Ment Dis 189: 562–564

    Article  PubMed  Google Scholar 

  • Murphy KC, Owen MJ (2001) Velo-cardio-facial syndrome: a model for understanding the genetics and pathogenesis of schizophrenia. Br J Psychiatry 179: 397–402. Der Artikel weist auf die bis vor kurzem unbekannte deutliche Häufung psychotischer Erkrankungen bei einem Syndrom mit bekannter genetischer Ursache hin. Er verdeutlicht exemplarisch die Forschungsstrategie, bei genetisch bereits aufgeklärten Erkrankungen außerhalb des eigentlichen „psychiatrischen“ Krankheitspektrums nach bestimmten psychiatrischen Symptomen zu suchen, um deren genetische Basis zu verstehen.

    Article  PubMed  Google Scholar 

  • Myles-Worsley M, Coon H et al. (1999) Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. Am J Med Genet 88: 544–550

    Article  PubMed  Google Scholar 

  • Nestadt G, Samuels J, Riddle M et al. (2000) A family study of obsessivecompulsive disorder. Arch Gen Psychiatry 57: 358–363

    Article  PubMed  Google Scholar 

  • Nuechterlein KH (1983) Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. J Abnorm Psychol 92: 4–28

    Article  PubMed  Google Scholar 

  • O’Donovan, M. C., Craddock, N., Norton, N., et al. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40(9): 1053–1055.

    Article  PubMed  Google Scholar 

  • van Os J, Jones P, Lewis G, et al. (1997) Developmental precursors of affective illness in a general population birth cohort. Arch Gen Psychiatry 54: 625–631

    PubMed  Google Scholar 

  • Ozkaragoz T, Satz P, Noble EP (1997) Neuropsychological functioning in sons of active alcoholic, recovering alcoholic, and social drinking fathers. Alcohol 14: 31–37

    Article  PubMed  Google Scholar 

  • Ozonoff S, Rogers SJ, Farnham JM, Pennington BF (1993) Can standard measures identify subclinical markers of autism? J Autism Dev Disord 23: 429–441

    Article  PubMed  Google Scholar 

  • Papassotiropoulos A, Stephan DA, Huentelman MJ et al. (2006) Common Kibra alleles are associated with human memory performance. Science 314: 475–478.

    Article  PubMed  Google Scholar 

  • Parasuraman, R., Greenwood, P. M., Kumar, R., Fossella, J. (2005). Beyond heritability: neurotransmitter genes differentially modulate visuospatial attention and working memory. Psychol Sci 16(3): 200–207.

    Article  PubMed  Google Scholar 

  • Park S, Holzman PS, Goldman-Rakic PS (1995) Spatial working memory deficits in the relatives of schizophrenic patients. Arch Gen Psychiatry 52: 821–828

    PubMed  Google Scholar 

  • Persico AM, D’Agruma L, Maiorano N et al. (2001) Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Mol Psychiatry 6: 150–159

    Article  PubMed  Google Scholar 

  • Petrovsky, N., Weiss-Motz, F., Schulze-Rauschenbach, S., et al. (2009). Antisaccade performance is related to genetic loading for schizophrenia. J Psychiatr Res 43: 291–297

    Article  PubMed  Google Scholar 

  • Phillips ML, Young AW, Senior C et al. (1997) A specific neural substrate for perceiving facial expressions of disgust. Nature 389: 495–498.

    Article  PubMed  Google Scholar 

  • Pierson A, Jouvent R, Quintin P, et al. (2000) Information processing deficits in relatives of manic depressive patients. Psychol Med 30: 545–555

    Article  PubMed  Google Scholar 

  • Plomin R, DeFries JC, McClearn GE, McGuffin P (2001) Behavioral Genetics, 4th edn. Worth, New York

    Google Scholar 

  • Purcell R, Maruff P, Kyrios M, Pantelis C (1998) Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiatry 55: 415–423

    Article  PubMed  Google Scholar 

  • de Quervain DJ, Henke K, Aerni A, et al. (2003) A functional genetic variation of the 5-HT2a receptor affects human memory. Nat Neurosci. 6:1141–1142

    Article  PubMed  Google Scholar 

  • Reuter M, Ott U, Vaitl D, Hennig J (2007) Impaired executive control is associated with a variation in the promoter region of the tryptophan hydroxylase 2 gene. Journal of Cognitive Neuroscience 19:401–408.

    Article  PubMed  Google Scholar 

  • Riley, B., Thiselton, D., Maher, B. S., et al. (2009). Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry [Epub ahead of print Dec 22, 2009].

    Google Scholar 

  • Roitman SE, Cornblatt BA, Bergman A et al. (1997) Attentional functioning in schizotypal personality disorder. Am J Psychiatry 154: 655–660

    PubMed  Google Scholar 

  • Ross RG, Harris JG, Olincy A, et al. (1998a) Familial transmission of two independent saccadic abnormalities in schizophrenia. Schizophr Res 30: 59–70

    Article  PubMed  Google Scholar 

  • Ross RG, Olincy A, Harris JG, et al. (1998b) Anticipatory saccades during smooth pursuit eye movements and familial transmission of schizophrenia. Biol Psychiatry 44: 690–697

    Article  PubMed  Google Scholar 

  • Savage CR, Baer L, Keuthen NJ, et al. (1999) Organizational strategies mediate nonverbal memory impairment in obsessive-compulsive disorder. Biol Psychiatry 45: 905–916

    Article  PubMed  Google Scholar 

  • Schaper K, Kölsch, H, Popp J, et al. (2008). KIBRA gene variants are associated with episodic memory in healthy elderly. Neurobiol Aging 29:1123–1125

    Article  PubMed  Google Scholar 

  • Schröder C, Maier W, Wagner M (2002) A meta-analysis of neurocognitive deficits in relatives of patients with schizophrenia. Schizophr Res 53: 126–127

    Google Scholar 

  • Seidman LJ, Biederman J, Monuteaux MC, et al. (2000) Neuropsychological functioning in nonreferred siblings of children with attention deficit/hyperactivity disorder. J Abnorm Psychol 109: 252–265

    Article  PubMed  Google Scholar 

  • Seidman LJ, Faraone SV, Goldstein JM et al. (2002) Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic firstdegree relatives. Arch Gen Psychiatry 59: 839–849. Eine neuere Arbeit aus der großen Harvard-Brockton-Familienstudie zur Schizophrenie (weitere Publikationen hierzu z. B. von Kremen und Faraone), die bei nicht erkrankten Verwandten 1. Grades von schizophrenen Patienten eine Volumenminderung im linken Hippokampus, wie bei den Patienten selbst, fand. Diese Volumenminderung war besonders bei Angehörigen aus Familien mit mehreren Krankheitsfällen ausgeprägt, korrelierte mit der Leistungsminderung im deklarativen Gedächtnis und könnte Resultat einer, möglicherweise genetisch mitbedingten, Störung der Hirnentwicklung sein, die einen Vulnerabilitätsfaktor für die Entwicklung der Krankheit darstellt.

    Article  PubMed  Google Scholar 

  • Sharma T, Lancaster E, Sigmundsson T et al. (1999) Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study. Schizophr Res 40: 111–120

    Article  PubMed  Google Scholar 

  • Shenton ME, Solovay MR, Holzman PS, et al. (1989) Thought disorder in the relatives of psychotic patients. Arch Gen Psychiatry 46: 897–901

    PubMed  Google Scholar 

  • Sitskoorn MM, Aleman A, Ebisch SJ, et al. (2004) Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophrenia Research 71:285–295

    Article  PubMed  Google Scholar 

  • Snitz BE, Macdonald AW, Carter CS. (2005) Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull. 32:179–194

    Article  PubMed  Google Scholar 

  • Stefansson H, Ophoff RA, Steinberg S et al. (2009) Common variants conferring risk of schizophrenia. Nature 6;460(7256):744-7.

    Google Scholar 

  • Stoltenberg SF, Glass JM, Chermack ST et al. (2006) Possible association between response inhibition and a variant in the brain-expressed tryptophan hydroxylase-2 gene. Psychiatr Genet 16:35–38

    Article  PubMed  Google Scholar 

  • Stratta P, Daneluzzo E, Mattei P, et al. (1997) No deficit in Wisconsin Card Sorting Test performance of schizophrenic patients’ first-degree relatives. Schizophr Res 26: 147–151

    Article  PubMed  Google Scholar 

  • Tam GW, Redon R, Carter NP, Grant SG (2009) The role of DNA copy number variation in schizophrenia. Biol Psychiatry 66(11): 1005–12.

    Article  PubMed  Google Scholar 

  • Wagner M, Maier W (2008) Genetische Aspekte neuropsychologischer Störungen bei schizophrenen Patienten. In: T. Kircher u. S. Gauggel (Eds.) Neuropsychologie der Schizophrenie. Symptome, Kognition, Gehirn (S. 44-57). Heidelberg: Springer

    Google Scholar 

  • Wagner M, Schuhmacher A, Schwab S, et al. (2008) The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans. Int J Neuropsychopharmacol 11:1163–1167

    Article  PubMed  Google Scholar 

  • Whyte MC, Brett C, Harrison LK, et al. (2006) Neuropsychological performance over time in people at high risk of developing schizophrenia and controls. Biol Psychiatry 59: 730–739

    Article  PubMed  Google Scholar 

  • Weisbrod M, Hill H, Niethammer R, Sauer H (1999) Genetic influence on auditory information processing in schizophrenia: P300 in monozygotic twins. Biol Psychiatry 46: 721–725

    Article  PubMed  Google Scholar 

  • Winterer G, Musso F, Konrad A, et al. (2007). Association of attentional network funktion with exon 5 variations of the CHRNA4 gene. Hum Mol Genet 16 (18): 2165–2174.

    Article  PubMed  Google Scholar 

  • Zakzanis KK, Leach L, Kaplan EF (1999) Neuropsychological differential diagnosis. Swets & Zeitlinger, Lisse/NL

    Google Scholar 

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Wagner, M., Petrovsky, N. (2010). Genetische Aspekte der Neuropsychologie psychischer Störungen. In: Lautenbacher, S., Gauggel, S. (eds) Neuropsychologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72340-0_8

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