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Molecular Carcinogenesis

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Key Topics in Surgical Research and Methodology

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Abstract

Over the last 20 years, the systematic application of molecular methodologies has revealed a series of cellular events that contribute to cancer development. Although it is clear that each tumor type is unique in terms of pathogenesis and progression, carcinogenesis seems to follow some characteristic fundamental principles, including nonlethal genetic damage, clonal expansion of a single transformed cell, as well as alterations in proto-oncogenes and tumor suppressor genes, all presented in a progressive, multistep fashion.

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Authors and Affiliations

  1. Department of Histology & Embryology, Molecular Carcinogenesis Group, Medical School, University of Athens, 75 Mikras Asias Street, Goudi, Athens, 11527, Greece

    Michael Zachariadis, Konstantinos Evangelou, Nikolaos G. Kastrinakis, Panagiota Papanagnou & Vassilis G. Gorgoulis

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  1. Michael Zachariadis
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  2. Konstantinos Evangelou
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  3. Nikolaos G. Kastrinakis
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  4. Panagiota Papanagnou
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  5. Vassilis G. Gorgoulis
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Editors and Affiliations

  1. Dept. Biosurgery & Surgical Technology, Imperial College London St. Mary's Hospital London, 10th floor QEQM Bldg. Praed Street, London, W2 1NY, United Kingdom

    Thanos Athanasiou  & Ara Darzi  & 

  2. UCSF Global Health Sciences, 3333 California Street, Suite 285, San Francisco L, CA, 94143-0443, USA

    Haile Debas

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Zachariadis, M., Evangelou, K., Kastrinakis, N.G., Papanagnou, P., Gorgoulis, V.G. (2010). Molecular Carcinogenesis. In: Athanasiou, T., Debas, H., Darzi, A. (eds) Key Topics in Surgical Research and Methodology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71915-1_74

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