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Questions of Cell Shape

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Book cover Neuroacanthocytosis Syndromes II

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This chapter considers existing knowledge regarding the molecular basis of the mechanisms of bending of cell membranes, and then attempts to relate this knowledge to the possible pathophysiology underlying the neuroacanthocytosis syndromes. Curvature of animal cell membranes can be induced by a series of different mechanisms: by insertion or deletion of phospholipid from inner or outer leaflet; by contraction or expansion of the underlying cytoskeleton; by binding of soluble, typically cytoplasmic, proteins to either the lipid bilayer directly or to adaptor integral proteins; or (theoretically) by change in conformation of integral membrane proteins. Any of these, alone or in combination, could be active in chorea-acanthocytosis/McLeod syndrome. Striking electron micrographs suggest that there is a degree of cytoskeletal disorganisation in both of these conditions.

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Author information

Authors and Affiliations

  1. Department of Medicine, University College London, Rayne Building, University Street, London, WC1E 6JJ, UK

    G. W. Stewart & S. M. S. Wilmore

  2. Department of Anatomy, Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan

    S. Ohno & N. Terada

Authors
  1. G. W. Stewart
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  2. S. M. S. Wilmore
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  3. S. Ohno
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  4. N. Terada
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Editor information

Editors and Affiliations

  1. Movement Disorders Clinic Department of Neurology, James J. Peters Veterans Affairs Medical Center, 130 W. Kingsbridge Road (127), Bronx, NY 10468

    Ruth H. Walker

  2. Department of Neurology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA

    Ruth H. Walker

  3. Department of Medical Genetics Cambridge Institute for Medical Research Wellcome Trust/MRC Building, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 2XY, UK

    Shinji Saiki

  4. Neurologische Klinik, Ludwig-Maximilians-Universität, D-81366, München, Germany

    Adrian Danek

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Stewart, G.W., Wilmore, S.M.S., Ohno, S., Terada, N. (2008). Questions of Cell Shape. In: Walker, R.H., Saiki, S., Danek, A. (eds) Neuroacanthocytosis Syndromes II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71693-8_9

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