Interferon Research: Impact on Understanding Transcriptional Control

  • J. E. DarnellJr.
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 316)


Celebrations are certainly in order for the 50th anniversary of the Isaacs/Lindenmann discovery of interferon as a secreted substance of probable cellular origin that conferred resistance to at least four viruses of distinctly different character—influenza, Sendai, Newcastle’s disease, and vaccinia. Personal pride, excusable, I hope, leads me to recall also that following the trail of how interferon works its magic led 15 years ago this year to the discovery of the STATs and their activation by the Jak kinases. These later findings were stimulated by and in turn further stimulated an ever deepening interest in how transcription figured in changing cell behavior. Here are presented some further reflections on these topics.


Mouse Mammary Tumor Virus Antiviral State Interferon Cytokine Effect Stat Activation Nonphosphorylated STAT1 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • J. E. DarnellJr.
    • 1
  1. 1.Laboratory of Molecular Cell BiologyThe Rockefeller UniversityNew YorkUSA

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