The Receptor of the Type I Interferon Family

  • G. Uzé
  • G. Schreiber
  • J. Piehler
  • S. Pellegrini
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 316)

Abstract

All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how a multitude of subtypes can generate similar signaling outputs but also govern specific cellular responses. This review summarizes results from the last decade that contributed to our current state of knowledge of IFN-receptor complex structure and assembly.

Keywords

Ternary Complex Receptor Subunit Interferon Receptor FNIII Domain Helical Cytokine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • G. Uzé
    • 1
  • G. Schreiber
    • 2
  • J. Piehler
    • 3
  • S. Pellegrini
    • 4
  1. 1.CNRS UMR 5124University Montpellier IIMontpellier cedex 5France
  2. 2.Department of Biological ChemistryWeizmann Institute of ScienceRehovotIsrael
  3. 3.Institute of Biochemistry, Biocenter N210Johann Wolfgang Goethe UniversityFrankfurt-am-MainGermany
  4. 4.Unit of Cytokine Signaling, CNRS URA 1961Institut PasteurParisFrance

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