Purification and Cloning of Interferon Alpha

  • S. Pestka
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 316)


Interferon alpha (IFN-α) was approved by the US Food and Drug Administration on June 5, 1986 and paved the way for development of many other cytokines and growth factors. Nevertheless, we have barely touched the surface of understanding the multitude of human IFNs. This paper reviews the history of the purification of human leukocyte IFN, the cloning of the IFN-αs, and the current state of knowledge of human interferon alpha genes and proteins.


Sugar HPLC Carbohydrate Polypeptide Interferon 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • S. Pestka
    • 1
    • 2
  1. 1.Department of Molecular Genetics, Microbiology and ImmunologyRobert Wood Johnson Medical SchoolPiscatawayUSA
  2. 2.PBL Biomedical LaboratoriesPiscatawayUSA

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