Viral Regulation and Evasion of the Host Response
The type I interferons (IFN) are cytokines produced by mammalian cells in response to virus infection or other Stressors. IFNs exert antiviral function by binding to the IFNα/β receptors on the cell surface, with the major effect of triggering the JAK-STAT signaling cascade and inducing the expression of interferon-stimulated genes. The resulting innate antiviral response is a first line of immune defense against virus infection. Recent studies demonstrate that many viruses, including hepatitis C virus, direct processes to control the host response to infection. We provide a review of the virus/host processes involved in IFN signaling and regulation of innate immune defenses.
KeywordsWest Nile Virus Interferon Regulatory Factor Japanese Encephalitis Virus Rift Valley Fever Virus Viral Regulation
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