Viral Regulation and Evasion of the Host Response

  • Y.-M. Loo
  • M. GaleJr.
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 316)

Abstract

The type I interferons (IFN) are cytokines produced by mammalian cells in response to virus infection or other Stressors. IFNs exert antiviral function by binding to the IFNα/β receptors on the cell surface, with the major effect of triggering the JAK-STAT signaling cascade and inducing the expression of interferon-stimulated genes. The resulting innate antiviral response is a first line of immune defense against virus infection. Recent studies demonstrate that many viruses, including hepatitis C virus, direct processes to control the host response to infection. We provide a review of the virus/host processes involved in IFN signaling and regulation of innate immune defenses.

Keywords

West Nile Virus Interferon Regulatory Factor Japanese Encephalitis Virus Rift Valley Fever Virus Viral Regulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Y.-M. Loo
    • 1
  • M. GaleJr.
    • 1
  1. 1.Department of ImmunologyUniversity of Washington School of MedicineSeattleUSA

Personalised recommendations