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Postoperative Staging of Pancreatic Cancer

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Book cover Pancreatic Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 177))

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Abstract

Pancreatic cancer is a devastating disease with a 5-year survival rate of 3%–5%. The mortality of pancreatic cancer is almost identical with its incidence. The vast majority are pancreatic ductal adenocarcinomas. It is typically a tumour of the elderly. The main risk factor is smoking. Clinical and histopathological studies have identified pancreatic cancer precursor lesions. These include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasia (IPMN) and mucinous cystic neoplasm (MCN). To improve patient prognosis, surgical interventions have become more aggressive, including pancreaticoduodenectomy and more or less radical lymphadenectomy. Following surgery, it is the surgical pathologist who provides valuable information regarding the exact tumour localization, histological tumour type, grading, completeness of resection, nodal status and the presence of precursor lesions.

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References

  1. Adsay NV, Basturk O, Bonnett M, et al. (2005) A proposal for a new and more practical grading scheme for pancreatic ductal adenocarcinoma. Am J Surg Pathol 29:724–733

    Article  PubMed  Google Scholar 

  2. Albores-Saaverda J, Hefess C, Hruban RH, et al. (1998) Recommendations for the reporting of pancreatic specimens containing malignant tumours. Association of Directors of Anatomic and Surgical Pathology. Hum Pathol 29:893–895

    Google Scholar 

  3. Alderson D, Johnson CD, Neoptolomeos JP, et al. (2005) Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut 54 [Suppl 5]:v1–v16

    Google Scholar 

  4. Anderson NL, Anderson NG (2002) The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics 1:845–867

    Article  PubMed  CAS  Google Scholar 

  5. Anderson NL, Polanski M, Pieper R, et al. (2004) The human plasma proteome: a non-redundant list developed by combination of four separate sources. Mol Cell Proteomics 3:311–326

    Article  PubMed  CAS  Google Scholar 

  6. Benassai G, Mastrorilli M, Quarto G, et al. (2000) Factors influencing survival after resection for ductal adenocarcinoma of the head of the pancreas. J Surg Oncol 73:212–218

    Article  PubMed  CAS  Google Scholar 

  7. Bhattacharyya S, Siegel ER, Petersen GM, et al. (2004) Diagnosis of pancreatic cancer using serum proteomic profiling. Neoplasia 6:674–686

    Article  PubMed  CAS  Google Scholar 

  8. Brennan MF, Kattan MW, Klimstra D, Conlon K (2004) Prognostic nomogram for patients undergoing resection for adenocarcinoma of the pancreas. Ann Surg 240:293–298

    Article  PubMed  Google Scholar 

  9. Carpelan-Holmstrom M, Nordling S, Pukkala E, et al. (2005) Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Gut 54:385–387

    Article  PubMed  CAS  Google Scholar 

  10. Chen R, Yi EC, Donohoe S, Pan S, et al. (2005) Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape. Gastroenterology 129:1187–1197

    Article  PubMed  CAS  Google Scholar 

  11. Compton CC, Henson DE (1997) Protocol for the examination of specimens removed from patients with carcinoma of the exocrine pancreas: a basis for checklists. Cancer Committee, College of American Pathologists. Arch Pathol Lab Med 121:1129–1136

    PubMed  CAS  Google Scholar 

  12. Ebert MP, Korc M, Malfertheiner P, Röcken C (2006) Advances, challenges, and limitations in serum-proteome-based cancer diagnosis. J Proteome Res 5:19–25

    Article  PubMed  CAS  Google Scholar 

  13. Garcea G, Neal CP, Pattenden CJ, et al. (2005) Molecular prognostic markers in pancreatic cancer: a systematic review. Eur J Cancer 41:2213–2236

    Article  PubMed  CAS  Google Scholar 

  14. Gebhardt C, Meyer W, Reichel M, Wunsch PH (2000) Prognostic factors in the operative treatment of ductal pancreatic carcinoma. Langenbecks Arch Surg 385:14–20

    Article  PubMed  CAS  Google Scholar 

  15. Gronborg M, Bunkenborg J, Kristiansen TZ, et al. (2004) Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res 3:1042–1055

    Article  PubMed  CAS  Google Scholar 

  16. Gronborg M, Kristiansen TZ, Iwahori A, et al. (2005) Biomarker discovery from pancreatic cancer secretome using a differential proteomics approach. Mol Cell Proteomics 5:157–171

    Article  PubMed  Google Scholar 

  17. Hamilton SR, Aalton L (2000) Pathology and genetics of tumours of the digestive system. IARC Press, Lyon

    Google Scholar 

  18. Hezel AF, Kimmelman AC, Stanger BZ, et al. (2006) Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 20:1218–1249

    Article  PubMed  CAS  Google Scholar 

  19. Hruban RH, Adsay NV, Albores-Saavedra J, et al. (2001) Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 25:579–586

    Article  PubMed  CAS  Google Scholar 

  20. Hruban RH, Takaori K, Klimstra DS, et al. (2004) An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 28:977–987

    Article  PubMed  Google Scholar 

  21. Karhu R, Mahlamaki E, Kallioniemi A (2006) Pancreatic adenocarcinoma—genetic portrait from chromosomes to microarrays. Genes Chromosomes Cancer 45:721–730

    Article  PubMed  CAS  Google Scholar 

  22. Klimstra DS (2005) Cystic, mucin-producing neoplasms of the pancreas: the distinguishing features of mucinous cystic neoplasms and intraductal papillary mucinous neoplasms. Semin Diagn Pathol 22:318–329

    Article  PubMed  Google Scholar 

  23. Koopmann J, Zhang Z, White N, et al. (2004) Serum diagnosis of pancreatic adenocarcinoma using surface-enhanced laser desorption and ionization mass spectrometry. Clin Cancer Res 10:860–868

    Article  PubMed  CAS  Google Scholar 

  24. Kuhlmann KF, de Castro SM, Wesseling JG, et al. (2004) Surgical treatment of pancreatic adenocarcinoma; actual survival and prognostic factors in 343 patients. Eur J Cancer 40:549–558

    Article  PubMed  CAS  Google Scholar 

  25. Lander ES, Linton LM, Birren B, et al. (2001) Initial sequencing and analysis of the human genome. Nature 409:860–921

    Article  PubMed  CAS  Google Scholar 

  26. Lim JE, Chien MW, Earle CC (2003) Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients. Ann Surg 237:74–85

    Article  PubMed  Google Scholar 

  27. Lüttges J, Vogel I, Menke M, et al. (1998) The retroperitoneal resection margin and vessel involvement are important factors determining survival after pancreaticoduodenectomy for ductal adenocarcinoma of the head of the pancreas. Virchows Arch 433:237–242

    Article  PubMed  Google Scholar 

  28. Lüttges J, Zamboni G, Klöppel G (1999) Recommendation for the examination of pancreaticoduodenectomy specimens removed from patients with carcinoma of the exocrine pancreas. A proposal for a standardized pathological staging of pancreaticoduodenectomy specimens including a checklist. Dig Surg 16:291–296

    Article  PubMed  Google Scholar 

  29. Lüttges J, Schemm S, Vogel I, et al. (2000) The grade of pancreatic ductal carcinoma is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation. J Pathol 191:154–161

    Article  PubMed  Google Scholar 

  30. Maitra A, Kern SE, Hruban RH (2006) Molecular pathogenesis of pancreatic cancer. Best Pract Res Clin Gastroenterol 20:211–226

    Article  PubMed  CAS  Google Scholar 

  31. Millikan KW, Deziel DJ, Silverstein JC, et al. (1999) Prognostic factors associated with resectable adenocarcinoma of the head of the pancreas. Am Surg 65:618–623

    PubMed  CAS  Google Scholar 

  32. Moon HJ, An JY, Heo JS, et al. (2006) Predicting survival after surgical resection for pancreatic ductal adenocarcinoma. Pancreas 32:37–43

    Article  PubMed  Google Scholar 

  33. Niedergethmann M, Rexin M, Hildenbrand R, et al. (2002) Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma. Am J Surg Pathol 26:1578–1587

    Article  PubMed  Google Scholar 

  34. Pieper R, Gatlin CL, Makusky AJ, et al. (2003) The human serum proteome: display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins. Proteomics 3:1345–1364

    Article  PubMed  CAS  Google Scholar 

  35. Ridwelski K, Meyer F, Fahlke J, et al. (2001) Value of cytokeratin and Ca 19-9 antigen in immunohistological detection of disseminated tumour cells in lymph nodes in pancreas carcinoma. Chirurg 72:920–926

    Article  PubMed  CAS  Google Scholar 

  36. Röcken C, Ebert MP (2006) Pancreatic cancer proteome. Gastroenterology 130:1017–1018

    Article  PubMed  Google Scholar 

  37. Röcken C, Ebert MP, Roessner A (2004) Proteomics in pathology, research and practice. Pathol Res Pract 200:69–82

    Article  PubMed  Google Scholar 

  38. Rosty C, Christa L, Kuzdzal S, et al. (2002) Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res 62:1868–1875

    PubMed  CAS  Google Scholar 

  39. Sato N, Goggins M (2006) The role of epigenetic alterations in pancreatic cancer. J Hepatobiliary Pancreat Surg 13:286–295

    Article  PubMed  Google Scholar 

  40. Shekouh AR, Thompson CC, Prime W, et al. (2003) Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics 3:1988–2001

    Article  PubMed  CAS  Google Scholar 

  41. Sohn TA, Yeo CJ, Cameron JL, et al. (2000) Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 4:567–579

    Article  PubMed  CAS  Google Scholar 

  42. Takai S, Satoi S, Toyokawa H, et al. (2003) Clinicopathologic evaluation after resection for ductal adenocarcinoma of the pancreas: a retrospective, single-institution experience. Pancreas 26:243–249

    Article  PubMed  CAS  Google Scholar 

  43. Tseng JF, Raut CP, Lee JE, et al. (2004) Pancreaticoduodenectomy with vascular resection: margin status and survival duration. J Gastrointest Surg 8:935–949

    Article  PubMed  Google Scholar 

  44. Venter JC, Adams MD, Myers EW, et al. (2001) The sequence of the human genome. Science 291:1304–1351

    Article  PubMed  CAS  Google Scholar 

  45. Wenger FA, Peter F, Zieren J, et al. (2000) Prognosis factors in carcinoma of the head of the pancreas. Dig Surg 17:29–35

    Article  PubMed  CAS  Google Scholar 

  46. Wulfkuhle JD, Liotta LA, Petricoin EF (2003) Proteomic applications for the early detection of cancer. Nat Rev Cancer 3:267–275

    Article  PubMed  CAS  Google Scholar 

  47. Xia Q, Kong XT, Zhang GA, et al. (2005) Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer. Biochem Biophys Res Commun 330:526–532

    Article  PubMed  CAS  Google Scholar 

  48. Yeo CJ, Cameron JL, Lillemoe KD, et al. (2002) Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg 236:355–366

    Article  PubMed  Google Scholar 

  49. Yu KH, Rustgi AK, Blair IA (2005a) Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometry. J Proteome Res 4:1742–1751

    Article  PubMed  CAS  Google Scholar 

  50. Yu Y, Chen S, Wang LS, et al. (2005b) Prediction of pancreatic cancer by serum biomarkers using surface-enhanced laser desorption/ionization-based decision tree classification. Oncology 68:79–86

    Article  PubMed  CAS  Google Scholar 

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© 2008 Springer-Verlag Berlin Heidelberg

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Röcken, C., Ebert, M. (2008). Postoperative Staging of Pancreatic Cancer. In: Pancreatic Cancer. Recent Results in Cancer Research, vol 177. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71279-4_5

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  • DOI: https://doi.org/10.1007/978-3-540-71279-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-71266-4

  • Online ISBN: 978-3-540-71279-4

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