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Kognition bei Kindern und Jugendlichen mit Schizophrenie

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Book cover Neuropsychologie der Schizophrenie

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Die Prävalenz schizophrener Erkrankungen in der Gesamtbevölkerung beträgt maximal 1%, im Kindes- und Jugendalter (d. h. bis zum 18. Lebensjahr) hingegen erkranken nur 2 von 100.000 Personen (McKenna 1994). Bei nur 0,1–1% aller Schizophrenen tritt die Erkrankung vor dem 10. Lebensjahr auf, bei 4% vor dem 15. Lebensjahr (Mehler-Wex u. Warnke 2004). Es handelt sich somit um eine in dieser Altersgruppe im Vergleich zum Erwachsenenalter äußerst seltene Erkrankung.

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Literatur

  • Asarnow RF (1999) Neurocognitive impairments in schizophrenia: a piece of the epigenetic puzzle. Eur Child Adolesc Psychiatry 8(Suppl I): I/5–I/8

    Google Scholar 

  • Asarnow RF, Karatekin C (2001) Neurobehavioral perspective. In: Remschmidt H (ed) Schizophrenia in children and adolescents. Cambridge Univ Press, pp 135–167

    Google Scholar 

  • Asarnow RF, Tanguay PE, Bott L, Freeman BJ (1987) Patterns of intellectual functioning in non-retarded autistic and schizophrenic children. J Child Psychol Psychiatry 28: 237–280

    Article  Google Scholar 

  • Asarnow RF, Nuechterlein KH, Asamen J et al. (2002a) Neurocognitive functioning and schizophrenia spectrum disorders can be independent expressions of familial liability for schizophrenia in community control children: the UCLA family study. Schizophr Res 54: 111–120

    Article  PubMed  Google Scholar 

  • Asarnow RF, Nuechterlein KH, Subotnik KL et al. (2002b) Neurocognitive impairments in nonpsychotic parents of children with schizophrenia and attention-deficit/hyperactivity disorder: the University of California, Los Angeles Family Study. Arch Gen Psychiatry 59(11): 1053–1060

    Article  PubMed  Google Scholar 

  • Badura F, Trott GE, Mehler C et al. (2001) A study of cranial computertomograms in very early and early onset schizophrenia. J Neural Transm 108: 1335–1344

    Article  PubMed  CAS  Google Scholar 

  • Barrantes-Vidal N, Fananas L, Rosa A et al. (2003) Neurocognitive, behavioural and neurodevelopmental correlates of schizotypy clusters in adolescents from the general population. Schizophr Res 61(2–3): 293–302

    Article  PubMed  Google Scholar 

  • Byrne M, Hodges A, Grant E, Owens DC, Johnstone EC (1999) Neuropsychological assessment for young people at high genetic risk for developing schizophrenia compared with controls: preliminary findings of the Edinburgh High Risk Study (EHRS). Psychol Med 29: 1161–1173

    Article  PubMed  CAS  Google Scholar 

  • Caplan R, Guthrie D, Foy JG (1992) Communication deficits and formal thought disorder in schizophrenic children. J Am Acad Child Adolesc Psychiatry 31: 151–159

    PubMed  CAS  Google Scholar 

  • Cornblatt BA, Keilp JG (1994) Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 20: 31–46

    PubMed  CAS  Google Scholar 

  • Cornblatt BA, Lenzenweger MF, Erlenmeyer-Kimling L (1989) The continuous performance test, identical pairs version: II. Contrasting attentional profiles of schizophrenic and depressed patients. Psychiatry Res 29:65–85

    Article  PubMed  CAS  Google Scholar 

  • Cornblatt BA, Obuchowski M, Roberts S, Pollack S, Erlenmeyer-Kimling L (1999) Cognitive and behavioural precursors of schizophrenia. Dev Psychopathol 11: 487–508

    Article  PubMed  CAS  Google Scholar 

  • Davalos DB, Compagnon N, Heinlein S, Ross RG (2004) Neuropsychological deficits in children associated with increased familial risk for schizophrenia. Schizophr Res 67: 123–130

    Article  PubMed  Google Scholar 

  • Diwadkar VA, Montrose DM, Dworakowski D, Sweeney JA, Keshavan MS (2005) Genetically predisposed offspring with schizotypal features: An ultra high-risk group for schizophrenia? Prog Neuropsychopharmacol Biol Psychiatry 30: 230–238

    Article  PubMed  Google Scholar 

  • Eggers C, Bunk D (1997) The long-term course of childhood-onset schizophrenia: a 42 year follow-up. Schizophr Bull 23(1): 105–117

    PubMed  CAS  Google Scholar 

  • Erlenmeyer-Kimling L, Rock D, Roberts SA et al. (2000) Attention, memory and motor skills as childhood predictors of schizophrenia-related psychoses, the New York High-Risk Project. Am J Psychiatry 157: 1416–1422

    Article  PubMed  CAS  Google Scholar 

  • Gochmann PA, Greenstein D, Sporn A et al. (2004) Childhood onset schizophrenia: familial neurocognitive measures. Schizophr Res 71: 43–47

    Article  Google Scholar 

  • Gur RE, Cowell P, Turetsky BI et al. (1998) A follow-up magnetic resonance imaging study of schizophrenia — relationship of neuroanatomical changes to clinical and neurobehavioral measures. Arch Gen Psychiatry 55: 145–152

    Article  PubMed  CAS  Google Scholar 

  • Karatekin C, Asarnow RF (1998) Working memory in childhood-onset schizophrenia and attention-deficit/hyperactivity disorder. Psychiatry Res 80: 165–176

    Article  PubMed  CAS  Google Scholar 

  • Keilp JG, Herrera J, Stritzke P, Cornblatt BA (1997) The continuous performance test, identical pairs version: III. Brain functioning during performance of numbers and shapes subtasks. Psychiatry Res 74: 35–45

    Article  PubMed  CAS  Google Scholar 

  • Keshavan MS, Sujata M, Mehra A, Montrose DM, Sweeney JA (2003) Psychosis proneness and ADHD in young relatives of schizophrenia patients. Schizophr Res 59: 85–92

    Article  PubMed  Google Scholar 

  • Kimble M, Lyons M, O’Donnell B et al. (2000) The effect of family status and schizotypy on electrophysiological measures of attention and semantic processing. Biol Psychiatry 47: 402–412

    Article  PubMed  CAS  Google Scholar 

  • Laurent A, Saoud M, Bougerol T et al. (1999) Attentional deficits in patients with schizophrenia and in their non-psychotic first-degree relatives. Psychiatry Res 89: 147–159

    Article  PubMed  CAS  Google Scholar 

  • Larrison AL, Ferrante CF, Briand KA, Sereno AB (2000) Schizotypal traits, attention and eye-movements. Prog Neuropsychopharmacol Biol Psychiatry 24: 357–372

    Article  PubMed  CAS  Google Scholar 

  • Lenzenweger MF (2001) Reaction time slowing during high-load, sustained attention task performance in relation to psychometrically identified schizotypy. J Abnorm Psychol 100:84–89

    Article  Google Scholar 

  • McKenna K, Gorden CT, Rapoport JL (1994) Childhood-onset schizophrenia: timely neurobiological research. J Am Acad Child Adolesc Psychiatry 33: 771–781

    Article  PubMed  CAS  Google Scholar 

  • Mehler C, Warnke A (2002) Structural brain abnormalities specific to childhood-onset schizophrenia identified by neuroimaging techniques. J Neural Transm 109: 219–234

    Article  PubMed  CAS  Google Scholar 

  • Mehler-Wex C, Warnke A (2004) Schizophrene Psychosen im Kindesalter und ihre Prognose. In: Nissen G (Hrsg) Psychische Störungen im Kindesalter und ihre Prognose. Schattauer, Stuttgart, New York, S 137–144

    Google Scholar 

  • Mehler-Wex C, Riederer P, Gerlach M (2006) Dopaminergic dysbalance in distinct basal ganglia neurocircuits: implications for the pathophysiology of Parkinson’s disease, schizophrenia and attention deficit hyperactivity disorder. Neurotoxic Res 10(3): 1–12

    Google Scholar 

  • Michie PT, Kent A, Stienstra R et al. (2000) Phenotypic markers as risk factors in schizophrenia: neurocognitive functions. Aust N Z J Psychiatry 34(Suppl): S74–S85

    Article  PubMed  Google Scholar 

  • Murray GK, Jones PB, Moilanen K et al. (2006) Infant motor development and adult cognitive functions in schizophrenia. Schizophr Res 81(1): 65–74

    Article  PubMed  CAS  Google Scholar 

  • Neumann CS, Walker EF (2003) Neuromotor functioning in adolescents with schizotypal personality disorder: associations with symptoms and neurocognition. Schizophr Bull 29(2): 285–298

    PubMed  Google Scholar 

  • Niemi LT, Suvisaari JM, Tuulio-Henriksson A, Lönnqvist JK (2002) Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies. Schizophr Res 60: 239–258

    Article  Google Scholar 

  • Niendam TA, Bearden CE, Rosso IM et al. (2003) A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Am J Psychiatry 160: 2060–2062

    Article  PubMed  Google Scholar 

  • Öner Ö, Munir K (2005) Attentional and neurocognitive characteristics of high-risk offspring of parents with schizophrenia compared with DSM-IV attention deficit hyperactivity disorder children. Schizophr Res 76: 293–299

    Article  PubMed  Google Scholar 

  • Randall G, Ross MD (2003) Early expression of a pathophysiological feature of schizophrenia: saccadic intrusions into smooth-pursuit eye movements in school-age children vulnerable to schizophrenia. J Am Acad Child Adolesc Psychiatry 42(4): 468–476

    Google Scholar 

  • Rapoport JL, Giedd J, Kumra S et al. (1997) Childhood-onset schizophrenia. Arch Gen Psychiatry 54: 897–903

    PubMed  CAS  Google Scholar 

  • Rhinewine JP, Lencz T, Thadan EP et al. (2005) Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlates. Biol Psychiatry 58(9): 705–712

    Article  PubMed  Google Scholar 

  • Ross RG, Olincy A, Harris JG, Sullivan B, Radant AD (2000) Smooth pursuit eye movements in schizophrenia and attentional dysfunction: adults with schizophrenia, ADHD and a normal comparison group. Biol Psychiatry 8: 690–697

    Google Scholar 

  • Ross RG, Olincy A, Mikulich SK et al. (2002) Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes. Psychophysiology 39: 809–819

    Article  PubMed  Google Scholar 

  • Ross RG, Heinlein S, Zerbe GO, Radant A (2005) Saccadic eye movement task identifies cognitive deficits in children with schizophrenia, but not in unaffected child relatives. J Child Psychol Psychiatry 46: 1354–1362

    Article  PubMed  Google Scholar 

  • Schaeffer JL, Ross RG (2002) Childhood-onset schizophrenia: premorbid and prodromal diagnostic and treatment histories. J Am Acad Child Adolesc Psychiatry 41: 538–545

    Article  PubMed  Google Scholar 

  • Schubert EW, McNeil TF (2005) Neuropsychological impairment and its neurological correlates in adult offspring with heightened risk for schizophrenia and affective psychoses. Am J Psychiatry 162(4): 758–766

    Article  PubMed  Google Scholar 

  • Seidman LJ, Stone WS, Jones R, Harrison RH, Mirsky AF (1998) Comparative effects of schizophrenia and temporal lobe epilepsy on memory. J Int Neuropsychol Soc 4: 342–352

    PubMed  CAS  Google Scholar 

  • Silverstein ML, Mavrolefteros G, Close D (2002) Premorbid adjustment and neuropsychological performance in schizophrenia. Schizophr Bull 28(1): 157–165

    PubMed  Google Scholar 

  • Trott GE, Gold-Carl H, Badura F (1999) Klinik, Verlauf und Therapie von schizophrenen Psychosen mit sehr frühem Krankheitsbeginn. In: Naber D, Müller-Spahn F (Hrsg) Leponex. Pharmakologie und Klinik eines atypischen Neuroleptikums. Springer, Berlin Heidelberg New York Tokio, S 51–62

    Google Scholar 

  • Volpz HP, Gaser C, Hager F et al. (1999) Decreased frontal activation in schizophrenics during stimulation with the continuous performance test — a functional magnetic resonance imaging study. Eur Psychiatry 14: 17–24

    Article  Google Scholar 

  • Yeon RA, Hodde-Vargas J, Hendren RL et al. (1997) Brain abnormalities in schizophrenia-spectrum children: implications for a neurodevelopmental perspective. Psychiatry Res Neuroimag Sect 76: 1–13

    Article  Google Scholar 

  • Zahn TP, Jacobsen L, Gordon CT et al. (1998) Attention deficits in childhood-onset schizophrenia: reaction time studies. J Abnorm Psychol 107: 97–108

    Article  PubMed  CAS  Google Scholar 

  • Zinkstok J, Amelsvoort T van (2005) Neuropsychological profile and neuroimaging in patients with 22Q11.2 deletion syndrome: a review. Child Neuropsychol 11(1): 21–37

    Article  PubMed  Google Scholar 

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Mehler-Wex, C., Schwenck, C., Warnke, A. (2008). Kognition bei Kindern und Jugendlichen mit Schizophrenie. In: Neuropsychologie der Schizophrenie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71147-6_7

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  • DOI: https://doi.org/10.1007/978-3-540-71147-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-71146-9

  • Online ISBN: 978-3-540-71147-6

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