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Einsatz von Neo-Hepatozyten zur Therapie des fibrotischen Leberschadens

  • Conference paper
Chirurgisches Forum 2007

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 36))

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Abstract

Hepatocyte transplantation has been successful in many animal models of acute liver failure. In contrast, only few clinical attempts have been made, mainly because of the lack of a reliable source of liver cells. Transplantation of human stem or precursor cells may represent an alternative technique. Herein, we evaluated whether transplantation of Neo-Hepatocytes, i. e. hepatocyte-like cells differentiated from blood monocytes, could sustain function and recovery of fibrotic liver tissue. A single intrahepatic transplantation of Neo-Hepatocytes did not support liver function (urea and ammonia plasma levels) as well as liver recovery (aspartate aminotransferase plasma level) in case of CCl4-induced liver fibrosis.

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Literatur

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Author information

Authors and Affiliations

  1. Institut für Experimentelle Chirurgie, Universität Rostock, Schillingallee 69a, 18055, Rostock

    Dr. rer. nat. Christian Eipel, K. Sievert & B. Vollmar

  2. Fresenius Biotech, Bad Homburg

    A. K. Nüssler

  3. Institut für Arbeitsphysiologie, Leibniz Research Centre for Working Environment and Human Factors, Universität Dortmund, Dortmund

    M. Brulport & J. G. Hengstler

Authors
  1. Dr. rer. nat. Christian Eipel
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  2. A. K. Nüssler
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  3. K. Sievert
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  4. M. Brulport
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  5. J. G. Hengstler
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  6. B. Vollmar
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Editor information

Editors and Affiliations

  1. Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Berufsgenossenschaftliche Universitätsklinik »Bergmannsheil« GmbH, Bürkle-de-la-Camp-Platz 1, 44789, Bochum

    H. -U. Steinau (Direktor) (Direktor)

  2. Abteilung Chirurgische Forschung Medizinische Fakultät Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden

    H. K. Schackert (Leiter) (Leiter)

  3. Deutsche Gesellschaft für Chirurgie Geschäftsstelle, Luisenstraße 58/59, 10117, Berlin

    H. Bauer

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© 2007 Springer Medizin Verlag Heidelberg

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Eipel, C., Nüssler, A.K., Sievert, K., Brulport, M., Hengstler, J.G., Vollmar, B. (2007). Einsatz von Neo-Hepatozyten zur Therapie des fibrotischen Leberschadens. In: Steinau, H.U., Schackert, H.K., Bauer, H. (eds) Chirurgisches Forum 2007. Deutsche Gesellschaft für Chirurgie, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71123-0_81

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  • DOI: https://doi.org/10.1007/978-3-540-71123-0_81

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-71122-3

  • Online ISBN: 978-3-540-71123-0

  • eBook Packages: Medicine (German Language)

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