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Multiscale Fractal Analysis of Cortical Pyramidal Neurons

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Bildverarbeitung für die Medizin 2007

Part of the book series: Informatik aktuell ((INFORMAT))

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Abstract

The present study used 3D data on neuronal morphology images to quantitatively characterize the phenotype of transgenic neurons. We calculated the multiscale fractal dimension (MFD) of reconstructed neuronal cells. It was shown that in a specific mouse mutant changes in the complexity of neuronal morphology correlate with changes in the MFD of dendrites of pyramidal neurons. Neurons in the mutant strain have lower peak fractal dimension compared with the wildtype, and a greater variety of the cell morphological phenotype.

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Author information

Authors and Affiliations

  1. Institute for Computer Science, University of Leipzig, D-04109, Leipzig, Germany

    Andreas Schierwagen

  2. Institute of Physics at São Carlos, University of São Paulo, 13560-970, São Carlos, SP, Brazil

    Luciano da Fontoura Costa

  3. Department of Neuroanatomy, Paul Flechsig Institut for Brain Research, University of Leipzig, D-04109, Leipzig, Germany

    Alán Alpár & Ulrich Gärtner

Authors
  1. Andreas Schierwagen
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  2. Luciano da Fontoura Costa
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  3. Alán Alpár
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  4. Ulrich Gärtner
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Editor information

Editors and Affiliations

  1. Klinikum rechts der Isar Institut für Medizinische Statistik und Epidemiologie, Technische Universität München, Ismaninger Strasse 22, 81675, München

    Alexander Horsch

  2. Institut für Medizinische Informatik, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52057, Aachen

    Thomas M. Deserno

  3. Institut für Medizinische Informatik, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg

    Heinz Handels

  4. Abt. für Medizinische und Biologische Informatik / H0100, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg

    Hans-Peter Meinzer

  5. Institut für Medizinische Informatik, Universitätsmedizin Berlin, Campus Benjamin Franklin Hindenburgdamm 30, 12200, Berlin

    Thomas Tolxdorff (Charité) (Charité)

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© 2007 Springer-Verlag Berlin Heidelberg

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Schierwagen, A., Costa, L.d.F., Alpár, A., Gärtner, U. (2007). Multiscale Fractal Analysis of Cortical Pyramidal Neurons. In: Horsch, A., Deserno, T.M., Handels, H., Meinzer, HP., Tolxdorff, T. (eds) Bildverarbeitung für die Medizin 2007. Informatik aktuell. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71091-2_85

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