Human Papillomavirus-Associated Lesions of the Urinary Tract

  • Alberto Rosenblatt
  • Homero Gustavo de Campos Guidi


Human papillomavirus (HPV) infection can affect the urethra of male and female individuals causing symptoms and concern. Urethral lesions (warts) may occasionally develop and the urethra can also be a source of HPV infection, contributing to the spread of infection between partners. This chapter reviews updated concepts concerning urethral HPV, including new detection methods, treatment options, and prevention. In addition, the role of HPV in the development of urethral, bladder, prostate, and kidney cancer is also discussed. The prevalence of urethral involvement among genital HPV-associated lesions is 4–25% (von Krogh, 2001) and the prevalence of HPV detection in the urethra, in the absence of clinical lesions, ranges from 3 to 50% (Rosemberg et al., 1988; Katelaris et al., 1988; Cecchini et al., 1988; Aynaud et al., 2003). Chuang et al. (1984) reported that the male ­urethra is affected more often than the female urethra, and recent analysis by von Krogh (2001) reported HPV-related meatal lesions in 20–25% of male and 4–8% of female individuals. Meatal warts have also been observed in children, and Takatsuki et al. (1993) described a relapsing meatal condyloma in a 4-year-old boy.


  1. Agarwal C, Hembree JR, Rorke EA, Eckert RL (1994) Interferon and retinoic acid suppress the growth of human papillomavirus type 16 immortalized cervical epithelial cells, but only interferon suppresses the level of the human papillomavirus transforming oncogenes. Cancer Res 54: 2108–2112PubMedGoogle Scholar
  2. Agliano AM, Gradilone A, Gazzaniga P, Napolitano M, Vercillo R, Albonici L, Naso G, Manzari V, Frati L, Vecchione A (1994) High frequency of human papillomavirus detection in urinary bladder cancer. Urol Int 53: 125–129PubMedCrossRefGoogle Scholar
  3. Aguilar LV, Lazcano-Ponce E, Vaccarella S, Cruz A, Hernandez P, Smith JS, Munoz N, Kornegay JR, Hernandez-Avila M, Franceschi S (2006) Human papillomavirus in men: Compar­ison of different genital sites. Sex Transm Infect 82: 31–33PubMedCrossRefGoogle Scholar
  4. Albarran YCA, de la Garza A, Cruz Quiroz BJ, Vazquez Zea E, Diaz Estrada I, Mendez Fuentez E, Lopez Contreras M, Andrade-Manzano A, Padilla S, Varela AR, Rosales R (2007) MVA E2 recombinant vaccine in the treatment of human papillomavirus infection in men presenting intraurethral flat condyloma: A phase I/II study. BioDrugs 21: 47–59CrossRefGoogle Scholar
  5. Anwar K, Naiki H, Nakakuki K, Inuzuka M (1992a) High frequency of human papillomavirus infection in carcinoma of the urinary bladder. Cancer 70: 1967–1973PubMedCrossRefGoogle Scholar
  6. Anwar K, Nakakuki K, Shiraishi T, Naiki H, Yatani R, Inuzuka M (1992b) Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas. Cancer Res 52: 5991–5996PubMedGoogle Scholar
  7. Aynaud O (1992) Meatal spreader. J Urol 147: 409PubMedGoogle Scholar
  8. Aynaud O, Ionesco M, Barrasso R (2003) Cytologic detection of human papillomavirus DNA in normal male urethral samples. Urology 61: 1098–1101PubMedCrossRefGoogle Scholar
  9. Aynaud O, Tranbaloc P, Orth G (1998) Lack of evidence for a role of human papillomaviruses in transitional cell carcinoma of the bladder. J Urol 159: 86–89; discussion 90PubMedCrossRefGoogle Scholar
  10. Bans LL, Eble JN, Lingeman JE, Maynard BR (1983) Transitional cell carcinoma of the fossa navicularis of the male urethra. J Urol 129: 1055–1056PubMedGoogle Scholar
  11. Barghi MR, Hajimohammadmehdiarbab A, Moghaddam SM, Kazemi B (2005) Correlation between human papillomavirus infection and bladder transitional cell carcinoma. BMC Infect Dis 5: 102PubMedCrossRefGoogle Scholar
  12. Benoit G, Orth G, Vieillefond A, Sinico M, Charpentier B, Jardin A, Fries D (1988) Presence of papilloma virus type 11 in condyloma acuminatum of bladder in female renal transplant recipient. Urology 32: 343–344PubMedCrossRefGoogle Scholar
  13. Beutner KR, Ferenczy A (1997) Therapeutic approaches to genital warts. Am J Med 102: 28–37PubMedCrossRefGoogle Scholar
  14. Bloiso G, Warner R, Cohen M (1988) Treatment of urethral diseases with neodymium:YAG laser. Urology 32: 106–110PubMedCrossRefGoogle Scholar
  15. Bohle A, Doehn C, Kausch I, Jocham D (1998) Treatment of recurrent penile condylomata acuminata with external application and intraurethral instillation of bacillus Calmette Guerin. J Urol 160: 394–396PubMedCrossRefGoogle Scholar
  16. Carpiniello VL, Schoenberg M, Malloy TR (1990) Long-term followup of subclinical human papillomavirus infection treated with the carbon dioxide laser and intraurethral 5-fluorouracil: A treatment protocol. J Urol 143: 726–728PubMedGoogle Scholar
  17. Cecchini S, Cipparrone I, Confortini M, Scuderi A, Meini L, Piazzesi G (1988) Urethral cytology of Cytobrush specimens. A new technique for detecting subclinical human papillomavirus infection in men. Acta Cytol 32: 314–317Google Scholar
  18. Chan KW, Wong KY, Srivastava G (1997) Prevalence of six types of human papillomavirus in inverted papilloma and papillary transitional cell carcinoma of the bladder: an eva­luation by polymerase chain reaction. J Clin Pathol 50: 1018–1021PubMedCrossRefGoogle Scholar
  19. Chang F, Lipponen P, Tervahauta A, Syrjanen S, Syrjanen K (1994) Transitional cell carcinoma of the bladder: Failure to demonstrate human papillomavirus deoxyribonucleic acid by in situ hybridization and polymerase chain reaction. J Urol 152: 1429–1433PubMedGoogle Scholar
  20. Chen K, Chang BZ, Ju M, Zhang XH, Gu H (2007) Comparative study of photodynamic therapy vs CO2 laser vaporization in treatment of condylomata acuminata: A randomized clinical trial. Br J Dermatol 156: 516–520PubMedCrossRefGoogle Scholar
  21. Chetsanga C, Malmstrom PU, Gyllensten U, Moreno-Lopez J, Dinter Z, Pettersson U (1992) Low incidence of human papillomavirus type 16 DNA in bladder tumor detected by the polymerase chain reaction. Cancer 69: 1208–1211PubMedCrossRefGoogle Scholar
  22. Choo CK, Ling MT, Chan KW, Tsao SW, Zheng Z, Zhang D, Chan LC, Wong YC (1999) Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading frames. Prostate 40: 150–158PubMedCrossRefGoogle Scholar
  23. Chrisofos M, Skolarikos A, Lazaris A, Bogris S, Deliveliotis C (2004) HPV 16/18-associated condyloma acuminatum of the urinary bladder: First international report and review of literature. Int J STD AIDS 15: 836–838PubMedCrossRefGoogle Scholar
  24. Chuang TY, Perry HO, Kurland LT, Ilstrup DM (1984) Condyloma acuminatum in Rochester, Minn., 1950–1978. I. Epidemiology and clinical features. Arch Dermatol 120: 469–475Google Scholar
  25. Clinical Effectiveness Group BAfSHaHB (2007) United Kingdom national guideline on the management of anogenital warts. In: British Association for Sexual Health and HIV (BASHH), London (UK)Google Scholar
  26. Culp OS, Kaplan IW (1944) Condylomata acuminata: Two hundred cases treated with podophyllin. Ann Surg 120: 251–256PubMedCrossRefGoogle Scholar
  27. de Carvalho JJ, Syrjanen KJ, Jacobino M, Rosa NT, Carvalho LZ (2006) Prevalence of genital human papillomavirus infections established using different diagnostic techniques among males attending a urological clinic. Scand J Urol Nephrol 40: 138–143PubMedCrossRefGoogle Scholar
  28. De Gaetani C, Ferrari G, Righi E, Bettelli S, Migaldi M, Ferrari P, Trentini GP (1999) Detection of human papillomavirus DNA in urinary bladder carcinoma by in situ hybridisation. J Clin Pathol 52: 103–106PubMedCrossRefGoogle Scholar
  29. D’Hauwers K, Depuydt C, Bogers JP, Stalpaert M, Vereecken A, Wyndaele JJ, Tjalma W (2007) Urine versus brushed samples in human papillomavirus screening: Study in both genders. Asian J Androl 9: 705–710PubMedCrossRefGoogle Scholar
  30. Dillner J, Knekt P, Boman J, Lehtinen M, Af Geijersstam V, Sapp M, Schiller J, Maatela J, Aromaa A (1998) Sero-epidemiological association between human-papillomavirus infection and risk of prostate cancer. Int J Cancer 75: 564–567PubMedCrossRefGoogle Scholar
  31. Dodd JG, Paraskevas M, McNicol PJ (1993) Detection of human papillomavirus 16 transcription in human prostate tissue. J Urol 149: 400–402PubMedGoogle Scholar
  32. Dyment PG (1996) Human papillomavirus infection. Adolesc Med 7: 119–130PubMedGoogle Scholar
  33. Effert PJ, Frye RA, Neubauer A, Liu ET, Walther PJ (1992) Human papillomavirus types 16 and 18 are not involved in human prostate carcinogenesis: Analysis of archival human prostate cancer specimens by differential polymerase chain reaction. J Urol 147: 192–196PubMedGoogle Scholar
  34. Fralick RA, Malek RS, Goellner JR, Hyland KM (1994) Urethroscopy and urethral cytology in men with external genital condyloma. Urology 43: 361–364PubMedCrossRefGoogle Scholar
  35. Friedman-Kien AE, Eron LJ, Conant M, Growdon W, Badiak H, Bradstreet PW, Fedorczyk D, Trout JR, Plasse TF (1988) Natural interferon alfa for treatment of condylomata acuminata. JAMA 259: 533–538PubMedCrossRefGoogle Scholar
  36. Furihata M, Inoue K, Ohtsuki Y, Hashimoto H, Terao N, Fujita Y (1993) High-risk human papillomavirus infections and overexpression of p53 protein as prognostic indicators in transitional cell carcinoma of the urinary bladder. Cancer Res 53: 4823–4827PubMedGoogle Scholar
  37. Gartman E (1956) Intraurethral verruca acuminata in men. J Urol 75: 717–718PubMedGoogle Scholar
  38. Giuliano AR, Nielson CM, Flores R, Dunne EF, Abrahamsen M, Papenfuss MR, Markowitz LE, Smith D, Harris RB (2007) The optimal anatomic sites for sampling heterosexual men for human papillomavirus (HPV) detection: The HPV detection in men study. J Infect Dis 196: 1146–1152PubMedCrossRefGoogle Scholar
  39. Gonzalvo Perez V, Ramada Benlloch F, Blasco Alfonso JE, Donderis Guastavino C, Pallas Costa Y, Navalon Verdejo P, Zaragoza Orts J (1994) [Endoscopic electrofulguration of intraurethral condylomata acuminata]. Actas Urol Esp 18: 234–236PubMedGoogle Scholar
  40. Graversen PH, Bagi P, Rosenkilde P (1990) Laser treatment of recurrent urethral condylomata acuminata in men. Scand J Urol Nephrol 24: 163–166PubMedCrossRefGoogle Scholar
  41. Grce M, Furcic I, Hrascan R, Husnjak K, Krhen I, Marekovic Z, Zeljko Z, Pavelic K (1997) Human papillomaviruses are not associated with renal carcinoma. Anticancer Res 17: 2193–2196PubMedGoogle Scholar
  42. Green J, Monteiro E, Bolton VN, Sanders P, Gibson PE (1991) Detection of human papillomavirus DNA by PCR in semen from patients with and without penile warts. Genitourin Med 67: 207–210PubMedGoogle Scholar
  43. Griffiths TR, Mellon JK (2000) Human papillomavirus and urological tumours: II. Role in bladder, prostate, renal and testicular cancer. BJU Int 85: 211–217Google Scholar
  44. Gutierrez J, Jimenez A, de Dios Luna J, Soto MJ, Sorlozano A (2006) Meta-analysis of studies analyzing the relationship between bladder cancer and infection by human papillomavirus. J Urol 176: 2474–2481; discussion 2481PubMedCrossRefGoogle Scholar
  45. Herberman RB, Ortaldo JR, Mantovani A, Hobbs DS, Kung HF, Pestka S (1982) Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. Cell Immunol 67: 160–167PubMedCrossRefGoogle Scholar
  46. Hisada M, Rabkin CS, Strickler HD, Wright WE, Christianson RE, van den Berg BJ (2000) Human papillomavirus antibody and risk of prostate cancer. JAMA 283: 340–341PubMedCrossRefGoogle Scholar
  47. Huguet Perez J, Errando Smet C, Regalado Pareja R, Rosales Bordes A, Salvador Bayarri J, Vicente Rodriguez J (1996) [Urethral condyloma in the male: Experience with 48 cases]. Arch Esp Urol 49: 675–680PubMedGoogle Scholar
  48. Ibrahim GK, Gravitt PE, Dittrich KL, Ibrahim SN, Melhus O, Anderson SM, Robertson CN (1992) Detection of human papillomavirus in the prostate by polymerase chain reaction and in situ hybridization. J Urol 148: 1822–1826PubMedGoogle Scholar
  49. Iwasawa A, Hiltunen-Back E, Reunala T, Nieminen P, Paavonen J (1997) Human papillomavirus DNA in urine specimens of men with condyloma acuminatum. Sex Transm Dis 24: 165–168PubMedCrossRefGoogle Scholar
  50. Jones DJ (1991) Haemospermia: A prospective study. Br J Urol 67: 88–90PubMedCrossRefGoogle Scholar
  51. Kamel D, Turpeenniemi-Hujanen T, Vahakangas K, Paakko P, Soini Y (1994) Proliferating cell nuclear antigen but not p53 or human papillomavirus DNA correlates with advanced clinical stage in renal cell carcinoma. Histopathology 25: 339–347PubMedCrossRefGoogle Scholar
  52. Kaplinsky RS, Pranikoff K, Chasan S, DeBerry JL (1995) Indications for urethroscopy in male patients with penile condylomata. J Urol 153: 1120–1121PubMedCrossRefGoogle Scholar
  53. Katelaris PM, Cossart YE, Rose BR, Thompson CH, Sorich E, Nightingale B, Dallas PB, Morris BJ (1988) Human papillomavirus: The untreated male reservoir. J Urol 140: 300–305PubMedGoogle Scholar
  54. Kilciler M, Bedir S, Erdemir F, Coban H, Erten K, Ors O, Ozgok Y (2007) Condylomata acuminata of external urethral meatus causing infravesical obstruction. Int Urol Nephrol 39: 107–109PubMedCrossRefGoogle Scholar
  55. Knowles MA (1992) Human papillomavirus sequences are not detectable by Southern blotting or general primer-mediated polymerase chain reaction in transitional cell tumours of the bladder. Urol Res 20: 297–301PubMedCrossRefGoogle Scholar
  56. Krogh J, Beuke HP, Miskowiak J, Honnens de Lichtenberg M, Nielsen OS (1990) Long-term results of carbon dioxide laser treatment of meatal condylomata acuminata. Br J Urol 65: 621–623PubMedCrossRefGoogle Scholar
  57. Kuwahara M, Fujisaki N, Kagawa S, Furihata M, Ohtsuki Y (1998) Determination of p53 protein and high-risk human papillomavirus DNA in carcinomas of the renal pelvis and ureter. Int J Mol Med 1: 703–707PubMedGoogle Scholar
  58. Levine LA, Elterman L, Rukstalis DB (1996) Treatment of subclinical intraurethral human papilloma virus infection with interferon alfa-2b. Urology 47: 553–557PubMedCrossRefGoogle Scholar
  59. Lu QL, Lalani el N, Abel P (1997) Human papillomavirus 16 and 18 infection is absent in urinary bladder carcinomas. Eur Urol 31: 428–432PubMedGoogle Scholar
  60. Maloney KE, Wiener JS, Walther PJ (1994) Oncogenic human papillomaviruses are rarely associated with squamous cell carcinoma of the bladder: Evaluation by differential polymerase chain reaction. J Urol 151: 360–364PubMedGoogle Scholar
  61. Masood S, Rhatigan RM, Powell S, Thompson J, Rodenroth N (1991) Human papillomavirus in prostatic cancer: No evidence found by in situ DNA hybridization. South Med J 84: 235–236PubMedCrossRefGoogle Scholar
  62. McKenna JG, McMillan A (1990) Management of intrameatal warts in men. Int J STD AIDS 1: 259–263PubMedGoogle Scholar
  63. McNicol PJ, Dodd JG (1990) Detection of papillomavirus DNA in human prostatic tissue by Southern blot analysis. Can J Microbiol 36: 359–362PubMedCrossRefGoogle Scholar
  64. McNicol PJ, Dodd JG (1991) High prevalence of human papillomavirus in prostate tissues. J Urol 145: 850–853PubMedGoogle Scholar
  65. Mevorach RA, Cos LR, di Sant’Agnese PA, Stoler M (1990) Human papillomavirus type 6 in grade I transitional cell carcinoma of the urethra. J Urol 143: 126–128PubMedGoogle Scholar
  66. Moonen PM, Bakkers JM, Kiemeney LA, Schalken JA, Melchers WJ, Witjes JA (2007) Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer. Eur Urol 52: 464–468PubMedCrossRefGoogle Scholar
  67. Mvula M, Iwasaka T, Iguchi A, Nakamura S, Masaki Z, Sugimori H (1996) Do human papillomaviruses have a role in the pathogenesis of bladder carcinoma. J Urol 155: 471–474PubMedCrossRefGoogle Scholar
  68. Noel JC, Thiry L, Verhest A, Deschepper N, Peny MO, Sattar AA, Schulman CC, Haot J (1994) Transitional cell carcinoma of the bladder: Evaluation of the role of human papillomaviruses. Urology 44: 671–675PubMedCrossRefGoogle Scholar
  69. Nuovo GJ, Hochman HA, Eliezri YD, Lastarria D, Comite SL, Silvers DN (1990) Detection of human papillomavirus DNA in penile lesions histologically negative for condylomata. Analysis by in situ hybridization and the polymerase chain reaction. Am J Surg Pathol 14: 829–836Google Scholar
  70. Olsen S, Marcussen N, Jensen KM, Lindeberg H (1995) Urethral condylomata, due to human papilloma virus (HPV) type 6/11., associated with transitional cell tumors in the bladder and ureter. A case report. Scand J Urol Nephrol Suppl 172: 51–55Google Scholar
  71. Rabkin CS, Biggar RJ, Melbye M, Curtis RE (1992) Second primary cancers following anal and cervical carcinoma: Evidence of shared etiologic factors. Am J Epidemiol 136: 54–58PubMedGoogle Scholar
  72. Rintala MA, Grenman SE, Pollanen PP, Suominen JJ, Syrjanen SM (2004) Detection of high-risk HPV DNA in semen and its association with the quality of semen. Int J STD AIDS 15: 740–743PubMedCrossRefGoogle Scholar
  73. Rintala MA, Pollanen PP, Nikkanen VP, Grenman SE, Syrjanen SM (2002) Human papillomavirus DNA is found in the vas deferens. J Infect Dis 185: 1664–1667PubMedCrossRefGoogle Scholar
  74. Rosemberg SK, Jacobs H, Fuller T (1982) Some guidelines in the treatment of urethral condylomata with carbon dioxide laser. J Urol 127: 906–908PubMedGoogle Scholar
  75. Rosemberg SK, Reid R, Greenberg M, Lorincz AT (1988) Sexually transmitted papillomaviral infection in the male: II. The urethral reservoir. Urology 32: 47–49CrossRefGoogle Scholar
  76. Rothman I, Berger RE, Kiviat N, Navarro AL, Remington ML (1994) Urethral meatal warts in men: results of urethroscopy and biopsy. J Urol 151: 875–877PubMedGoogle Scholar
  77. Rotola A, Monini P, Di Luca D, Savioli A, Simone R, Secchiero P, Reggiani A, Cassai E (1992) Presence and physical state of HPV DNA in prostate and urinary-tract tissues. Int J Cancer 52: 359–365PubMedCrossRefGoogle Scholar
  78. Salmon SE, Durie BG, Young L, Liu RM, Trown PW, Stebbing N (1983) Effects of cloned human leukocyte interferons in the human tumor stem cell assay. J Clin Oncol 1: 217–225PubMedGoogle Scholar
  79. Sand PK, Shen W, Bowen LW, Ostergard DR (1987) Cryotherapy for the treatment of proximal urethral condyloma acuminatum. J Urol 137: 874–876Google Scholar
  80. Sano T, Sakurai S, Fukuda T, Nakajima T (1995) Unsuccessful effort to detect human papillomavirus DNA in urinary bladder cancers by the polymerase chain reaction and in situ hybridization. Pathol Int 45: 506–512PubMedCrossRefGoogle Scholar
  81. Sawczuk I, Badillo F, Olsson CA (1983) Condylomata acuminata: Diagnosis and follow-up by retrograde urethrography. Urol Radiol 5: 273–274PubMedCrossRefGoogle Scholar
  82. Scheinfeld N, Lehman DS (2006) An evidence-based review of medical and surgical treatments of genital warts. Dermatol Online J 12: 5PubMedGoogle Scholar
  83. Shaw MB, Payne SR (2007) A simple technique for accurate diathermy destruction of urethral meatal warts. Urology 69: 975–976PubMedCrossRefGoogle Scholar
  84. Shibutani YF, Schoenberg MP, Carpiniello VL, Malloy TR (1992) Human papillomavirus associated with bladder cancer. Urology 40: 15–17PubMedCrossRefGoogle Scholar
  85. Simoneau M, LaRue H, Fradet Y (1999) Low frequency of human papillomavirus infection in initial papillary bladder tumors. Urol Res 27: 180–184PubMedCrossRefGoogle Scholar
  86. Sinclair AL, Nouri AM, Oliver RT, Sexton C, Dalgleish AG (1993) Bladder and prostate cancer screening for human papillomavirus by polymerase chain reaction: Conflicting results using different annealing temperatures. Br J Biomed Sci 50: 350–354PubMedGoogle Scholar
  87. Smetana Z, Keller T, Leventon-Kriss S, Huszar M, Lindner A, Mitrani-Rosenbaum S, Mendelson E, Smetana S (1995) Presence of human papilloma virus in transitional cell carcinoma in Jewish population in Israel. Cell Mol Biol (Noisy-le-grand) 41: 1017–1023Google Scholar
  88. Smetana Z, Malik Z, Orenstein A, Mendelson E, Ben-Hur E (1997) Treatment of viral infections with 5-aminolevulinic acid and light. Lasers Surg Med 21: 351–358PubMedCrossRefGoogle Scholar
  89. Steele GS, Fielding JR, Renshaw A, Loughlin KR (1997) Transitional cell carcinoma of the fossa navicularis. Urology 50: 792–795PubMedCrossRefGoogle Scholar
  90. Strand A, Rylander E, Wilander E, Zehbe I, Kraaz W (1996) Histopathologic examination of penile epithelial lesions is of limited diagnostic value in human papillomavirus infection. Sex Transm Dis 23: 293–298CrossRefGoogle Scholar
  91. Strickler HD, Burk R, Shah K, Viscidi R, Jackson A, Pizza G, Bertoni F, Schiller JT, Manns A, Metcalf R, Qu W, Goedert JJ (1998) A multifaceted study of human papillomavirus and prostate carcinoma. Cancer 82: 1118–1125PubMedCrossRefGoogle Scholar
  92. Strickler HD, Goedert JJ (2001) Sexual behavior and evidence for an infectious cause of prostate cancer. Epidemiol Rev 23: 144–151PubMedCrossRefGoogle Scholar
  93. Sumino Y, Emoto A, Satoh F, Nakagawa M, Mimata H (2006) Transitional cell carcinoma of the navicular fossa detected human papillomavirus 16. Int J Urol 13: 645–647PubMedCrossRefGoogle Scholar
  94. Sumino Y, Mimata H, Nomura Y (2004) Urethral condyloma acuminata following urethral instrumentation in an elderly man. Int J Urol 11: 928–930PubMedCrossRefGoogle Scholar
  95. Sur M, Cooper K, Allard U (2001) Investigation of human papillomavirus in transitional cell carcinomas of the urinary bladder in South Africa. Pathology 33: 17–20PubMedGoogle Scholar
  96. Takatsuki K, Kamiyama Y, Sato S, Amemiya H, Iizumi T, Yazaki T, Umeda T (1993) [A case report of condyloma acuminatum of urethral meatus in a boy]. Hinyokika Kiyo 39: 479–481PubMedGoogle Scholar
  97. Thin RN (1992) Meatoscopy: A simple technique to examine the distal anterior urethra in men. Int J STD AIDS 3: 21–23PubMedGoogle Scholar
  98. Volz LR, Carpiniello VL, Malloy TR (1994) Laser treatment of urethral condyloma: A five-year experience. Urology 43: 81–83PubMedCrossRefGoogle Scholar
  99. von Krogh G (2001) Management of anogenital warts (condylomata acuminata). Eur J Dermatol 11: 598–603; quiz 604PubMedGoogle Scholar
  100. Wang XL, Wang HW, Wang HS, Xu SZ, Liao KH, Hillemanns P (2004) Topical 5-aminolaevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata. Br J Dermatol 151: 880–885PubMedCrossRefGoogle Scholar
  101. Wen YC, Wu HH, Chen KK (2006) Pan-urethral wart treated with 5-fluorouracil intraurethral instillation. J Chin Med Assoc 69: 391–392PubMedCrossRefGoogle Scholar
  102. Wideroff L, Schottenfeld D, Carey TE, Beals T, Fu G, Sakr W, Sarkar F, Schork A, Grossman HB, Shaw MW (1996) Human papillomavirus DNA in malignant and hyperplastic prostate tissue of black and white males. Prostate 28: 117–123PubMedCrossRefGoogle Scholar
  103. Wiener JS, Liu ET, Walther PJ (1992) Oncogenic human papillomavirus type 16 is associated with squamous cell cancer of the male urethra. Cancer Res 52: 5018–5023PubMedGoogle Scholar
  104. Wiener JS, Walther PJ (1994) A high association of oncogenic human papillomaviruses with carcinomas of the female urethra: Polymerase chain reaction-based analysis of multiple histological types. J Urol 151: 49–53PubMedGoogle Scholar
  105. Wiwanitkit V (2005) Urinary bladder carcinoma and human papilloma virus infection, an appraisal of risk. Asian Pac J Cancer Prev 6: 217–218PubMedGoogle Scholar
  106. Workowski KA, Berman SM (2007) Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines. Clin Infect Dis 44(Suppl 3): S73–S76PubMedCrossRefGoogle Scholar
  107. Young R (1996) Usual variants of primary bladder lesions and secondary tumours of the bladder. In: Pathology of bladder cancer. Williams and Wilkins, Baltimore, pp 326–337Google Scholar
  108. Youshya S, Purdie K, Breuer J, Proby C, Sheaf MT, Oliver RT, Baithun S (2005) Does human papillomavirus play a role in the development of bladder transitional cell carcinoma? A comparison of PCR and immunohistochemical analysis. J Clin Pathol 58: 207–210PubMedCrossRefGoogle Scholar
  109. Yu Z, Xia T, Xue Z (1999) [The detection of high risk human papillomaviruses in papillary transitional cell carcinoma of urinary bladder]. Zhonghua Wai Ke Za Zhi 37: 369–371; 322PubMedGoogle Scholar
  110. Zaak D, Hofstetter A, Frimberger D, Schneede P (2003) Recurrence of condylomata acuminata of the urethra after conventional and fluorescence-controlled Nd:YAG laser treatment. Urology 61: 1011–1015PubMedCrossRefGoogle Scholar
  111. Zderic SA, Carpiniello VL, Malloy TR, Rando RF (1989) Urological applications of human papillomavirus typing using deoxyribonucleic acid probes for the diagnosis and treatment of genital condyloma. J Urol 141: 63–65PubMedGoogle Scholar
  112. Zheng W, Vilos G, McCulloch S, Borg P, Denstedt JD (2000) Electrical burn of urethra as cause of stricture after transurethral resection. J Endourol 14: 225–228PubMedCrossRefGoogle Scholar
  113. zur Hausen H (1996) Papillomavirus infections - a major cause of human cancers. Biochim Biophys Acta 1288: F55–F78PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Alberto Rosenblatt
    • 1
  • Homero Gustavo de Campos Guidi
  1. 1.Albert Einstein Jewish HospitalSao PauloBrasil

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