Ecological Havoc, the Rise of White-Tailed Deer, and the Emergence of Amblyomma americanum-Associated Zoonoses in the United States

  • C. D. Paddock
  • M. J. Yabsley
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 315)

Two infectious diseases, and one presumably infectious disease, each vectored by or associated with the bite of the lone star tick ( Amblyomma americanum ), were identified and characterized by clinicians and scientists in the United States during the 1980s and 1990s. These three conditions—human monocytic (or monocytotropic) ehrlichiosis (HME), Ehrlichia ewingii ehrlichiosis, and southern tick-associated rash illness (STARI)—undoubtedly existed in the United States prior to this time. However, the near-simultaneous recognition of these diseases is remarkable and suggests the involvement of a unifying process that thrust multiple pathogens into the sphere of human recognition.

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References

  1. Anderson BE, Dawson JE, Jones DC, Wilson KH (1991)Ehrlichia chaffeensis, a new species associated with human ehrlichiosis. J Clin Microbiol 29:2838–2842.PubMedGoogle Scholar
  2. Anderson BE, Greene CE, Jones DC, Dawson JE (1992a)Ehrlichia ewingii sp nov., the etiologic agent of canine granulocytic ehrlichiosis. Int J Syst Bacteriol 42:299–302.PubMedCrossRefGoogle Scholar
  3. Anderson BE, Sumner JW, Dawson JE, Tzianabos T, Greene CR, Olson JG, Fishbein DB, Olsen-Rasmussen M, Holloway BP, George EH (1992b) Detection of the etiologic agent of human ehrlichiosis by polymerase chain reaction. J Clin Microbiol 30:775–780.PubMedGoogle Scholar
  4. Anziani OS, Ewing SA, Barker RW (1990) Experimental transmission of a granulocytic form of the tribe Ehrlichieae byDermacentor variabilis andAmblyomma americanum to dogs. Am J Vet Res 51:929–931.PubMedGoogle Scholar
  5. Arens MQ, Liddell AM, Buening G, Gaudreault-Keener M, Sumner JW, Comer JA, Buller RS, Storch GA (2003) Detection by PCR and serology ofEhrlichia spp. in the blood of wild white-tailed deer in Missouri. J Clin Microbiol 41:1263–1265.PubMedCrossRefGoogle Scholar
  6. Armstrong PM, Rich SM, Smith DR, Hartl DL, Spielman A, Telford SR (1996) A newBorrelia infecting lone star ticks. Lancet 347:67–68.PubMedCrossRefGoogle Scholar
  7. Armstrong PM, Brunet LR, Spielman A, Telford SR (2001) Risk of Lyme disease: perceptions of residents of a lone star-tick infested community. Bull World Health Organ 79:916–925.PubMedGoogle Scholar
  8. Atwood EL, Lamb JT, Sonenshine DE (1965) A contribution to the epidemiology of Rocky Mountain spotted fever in the eastern United States. Am J Trop Med Hyg 14:831–837.PubMedGoogle Scholar
  9. Bakken JS (1998) The discovery of human granulocytotropic ehrlichiosis. J Lab Clin Med 132:175–180.PubMedCrossRefGoogle Scholar
  10. Bakken JS, Dumler JS, Chen SM, Eckman MR, Van Etta LL, Walker DH (1994) Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? J Am Med Assoc 272:212–218.CrossRefGoogle Scholar
  11. Barbour AG, Maupin GO, Teltow GJ, Carter CJ, Piesman J (1996) Identification of an uncultivableBorrelia species in the hard tickAmblyomma americanum: possible agent of a Lyme disease-like illness. J Infect Dis 173:403–409.PubMedGoogle Scholar
  12. Baumgartner DL (1988) Review of myiasis (Insecta: Diptera: Calliphoridae, Sarcophagidae) of Nearctic wildlife. Wildl Rehab 7:3–46.Google Scholar
  13. Bishopp FC, Trembley HL (1945) Distribution and hosts of certain North American ticks. J Parasitol 31:1–54.CrossRefGoogle Scholar
  14. Bloemer SR, Snoddy EL, Cooney JC, Fairbanks K (1986) Influence of deer exclusion on populations of lone star ticks and American dog ticks (Acari: Ixodidae). J Med Entomol 79:679–683.Google Scholar
  15. Bloemer SR, Zimmerman RH, Fairbanks K (1988) Abundance, attachement sites, and density estimators for lone star ticks (Acari: Ixodidae) infesting white-tailed deer. J Med Entomol 25:295–230.PubMedGoogle Scholar
  16. Bloemer SR, Mount GA, Morris A, Zimmerman RH, Barnard DR, Snoddy EL (1990) Management of lone star ticks (Acari: Ixodidae) in recreational areas with acaricide applications, vegetative management, and exclusion of white-tailed deer. J Med Entomol 27:543–550.PubMedGoogle Scholar
  17. Buller RS, Arens M, Hmiel SP, Paddock CD, Sumner JW, Rikihisa Y, Unver A, Gaudreault-Keener M, Manian FA, Liddell AM, Schmulewitz N, Storch GA (1999)Ehrlichia ewingii, a newly recognized agent of human ehrlichiosis. N Engl J Med 341:148–155.PubMedCrossRefGoogle Scholar
  18. Burgdorfer W, Hayes SF, Thomas LA (1981) A new spotted fever group rickettsia from the lone star tick Amblyomma americanum. In: Burgdorfer W, Anacker RL (eds) Rickettsiae and rickettsial diseases. Academic, New York, pp 595–602.Google Scholar
  19. Burkot TR, Mullen GR, Anderson R, Schneider BS, Happ CM, Zeidner NS (2001)Borrelia lonestari DNA in adultAmblyomma americanum ticks, Alabama. Emerging Infect Dis 7:471–473.PubMedGoogle Scholar
  20. Calhoun EL (1954) Natural occurrence of tularemia in the lone star tick and dogs in Arkansas. Am J Trop Med Hyg 3:360–366.PubMedGoogle Scholar
  21. Campbell BS, Bowles DE (1994) Human tick bite records in a United States Air Force population, 1989–1992: implications for tick-borne disease risk. J Wilderness Med 5:405–412.Google Scholar
  22. Centers for Disease Control and Prevention (2005) Summary of notifiable diseases—(2003) Morb Mortal Wkly Rep 52:1–85.Google Scholar
  23. Childs JE, Paddock CD (2003) The ascendancy ofAmblyomma americanum as a vector of pathogens affecting humans in the United States. Ann Rev Entomol 48:307–337.CrossRefGoogle Scholar
  24. Clark K (2004)Borrelia species in host seeking ticks and small mammals in northern Florida. J Clin Microbiol 42:576–586.Google Scholar
  25. Clymer BC, Howell DE, Hair JA (1970) Animal hosts of economically important ticks in east-central Oklahoma. Ann Entomol Soc Am 63:612–614.Google Scholar
  26. Collins DL, Nardy RV, Glasgow RD (1949) Some host relationships of Long Island ticks. J Econ Entomol 42:110–112.PubMedGoogle Scholar
  27. Comer JA, Nicholson WL, Paddock CD, Sumner JW, Childs JE (2000) Detection of antibodies reactive withEhrlichia chaffeensis in the raccoon. J Wildl Dis 36:705–712.PubMedGoogle Scholar
  28. Cooley RA, Kohls GM (1944) The genusAmblyomma (Ixodidade) in the United States. J Parasitol 30:77–111.CrossRefGoogle Scholar
  29. Cronon W (1983) Changes in the land. Indians, colonists, and the ecology of New England. Hill and Wang, New York.Google Scholar
  30. Davidson WR, Lockhart JM, Stallknecht DE, Howerth EA (1999) Susceptibility of red and gray foxes to infection by Ehrlichia chaffeensis. J Wildl Dis 35:696–702.PubMedGoogle Scholar
  31. Dasch GA, Kelly DJ, Richards AL, Sanchez JL, Rives CC (1993) Western blotting analysis of sera from military personnel exhibiting serological reactivity to spotted fever group rickettsiae. Am J Trop Med Hyg 49 [Suppl 3]:220.Google Scholar
  32. Dawson JE, Anderson BE, Fishbein DB, Sanchez JL, Goldsmith CS, Wilson KH, Duntley CW (1991) Isolation and characterization of anEhrlichia sp. from a patient diagnosed with human ehrlichiosis. J Clin Microbiol 29:2741–2745.PubMedGoogle Scholar
  33. Demma LJ, Holman RC, McQuiston JH, Krebs JW, Swerdlow DL (2005) Epidemiology of human ehrlichiosis and anaplasmosis in the United States. Am J Trop Med Hyg 73:400–409.PubMedGoogle Scholar
  34. Donahue JG, Piesman J, Spielman A (1987) Reservoir competence of white-footed mice for Lyme disease spirochetes. Am J Trop Med Hyg 36:92–96.PubMedGoogle Scholar
  35. Downing RL (1987) Success story: white-tailed deer. In: Restoring America’s Wildlife. US Dept Interior Fish and Wildlife Service, US Govt Printing Office, Washington, DC, pp 45–57.Google Scholar
  36. Dugan VG, Little SE, Beall AD, Stallknecht DE (2000) Natural infection of domestic goats with Ehrlichia chaffeensis. J Clin Microbiol 38:448–449.PubMedGoogle Scholar
  37. Dugan VG, Yabsley MJ, Tate CM, Mead DG, Munderloh UG, Herron MJ, Stallknecht DE, Little SE, Davidson WR (2006) Evaluation of a prototypeAnaplasma phagocytophilum surveillance system using white-tailed deer (Odocoileus virginianus) as natural sentinels. Vector Borne Zoonotic Dis 6:197–207.CrossRefGoogle Scholar
  38. Ewing SA, Roberson WR, Buckner RG, Hyat CS (1971) A new strain of Ehrlichia canis. J Am Vet Med Assoc 159:1771–1774.PubMedGoogle Scholar
  39. Ewing SA, Dawson JE, Kocan AA, Barker RW, Warner CK, Panciera RJ, Fox JC, Kocan KM, Blouin EF (1995) Experimental transmission ofEhrlichia chaffeensis (Rickettsiales: Ehrlichieae) among white-tailed deer byAmblyomma americanum (Acari:Ixodidae). J Med Entomol 32:368–374.PubMedGoogle Scholar
  40. Felz MW, Durden LA, Oliver JH (1996) Ticks parasitizing humans in Georgia and South Carolina. J Parasitol 82:505–508.PubMedCrossRefGoogle Scholar
  41. Felz MW, Chandler FW, Oliver JH, Rahn DW, Schreifer ME (1999) Solitary erythema migrans in Georgia and South Carolina. Arch Dermatol 135:955–960.CrossRefGoogle Scholar
  42. Fishbein DB (1990) Human ehrlichiosis in the United States. In: Williams JC, Kakoma I (eds) Ehrlichiosis. Kluwer, Amsterdam, pp 100–111.Google Scholar
  43. Fishbein DB, Dawson JE, Robinson LE (1994) Human ehrlichiosis in the United States, 1985–1990. Ann Intern Med 120:736–743.PubMedGoogle Scholar
  44. Fitch A (1870) Fourteenth report on the noxious, beneficial and other insects of the state of New York. Trans N Y State Ag Soc 30:355–381.Google Scholar
  45. Gardner SL, Holman RC, Krebs JW, Berkelman R, Childs JE (2003) National surveillance for the human ehrlichioses in the United States, 1997–2001, and proposed methods for evaluation of data quality. Ann N Y Acad Sci 990:80–89.PubMedCrossRefGoogle Scholar
  46. Geist V (1998) Deer of the world. Their evolution, behavior, and ecology. Stackpole Books, Mechanicsburg, PA.Google Scholar
  47. Ginsberg HS, Zhioua E (1996) Nymphal survival and habitat distribution ofIxodes scapularis andAmblyomma americanum ticks (Acari: Ixodidae) on Fire Island New York USA. Exp Appl Acarol 20:533–544.CrossRefGoogle Scholar
  48. Ginsberg HS, Ewing CP, O’Connell AF, Bosler EM, Daly JG, Sayre MW (1991) Increased population densities ofAmblyomma americanum (Acari: Ixodidae) on Long Island, New York. J Parasitol 77:493–495.PubMedCrossRefGoogle Scholar
  49. Ginsberg HS, Butler M, Zhioua E (2002) Effect of deer exclusion by fencing on abundance ofAmblyomma americanum (Acari: Ixodidae) on Fire Island New York, USA. J Vector Ecol 27:215–221.PubMedGoogle Scholar
  50. Goddard J (2002) A ten-year study of tick biting in Mississippi: implications for human disease transmission. J Agromed 8:25–32.CrossRefGoogle Scholar
  51. Goddard J, McHugh CP (1990) Impact of severe tick infestation at Little Rock AFB, Arkansas on Volant Scorpion military training. Military Med 155:277–280.Google Scholar
  52. Goddard J, Norment BR (1986) Spotted fever group rickettsiae in the lone star tickAmblyomma americanum (Acari: Ixodidae). J Med Entomol 23:465–472.PubMedGoogle Scholar
  53. Good NE (1973) Ticks of eastern Long Island: notes on host relations and seasonal distribution. Ann Entomol Soc Am 66:240–243.Google Scholar
  54. Goodman RA, Hawkins EC, Olby NJ, Grindem CB, Hegarty B, Breitschwerdt EB (2003) Molecular identification ofEhrlichia ewingii in dogs: 15 cases (1997–2001). J Am Vet Med Assoc 222:1102–1107.PubMedCrossRefGoogle Scholar
  55. Groves MG, Dennis GL, Amyx HL, Huxsoll DL (1975) Transmission ofEhrlichia canis to dogs by ticks (Rhipicephalus sanguineus). Am J Vet Res 36:937–940.PubMedGoogle Scholar
  56. Haddad FA, Schwartz I, Liveris D, Wormser GP (2005) A skin lesion in a patient from Kentucky. Clin Infect Dis 40:429 :475–476.CrossRefGoogle Scholar
  57. Hair JA, Howell DE (1970) Lone star ticks. Their biology and control in Ozark recreation areas. Oklahoma State University Agricultural Experiment Station Bulletin B 679:1–47.Google Scholar
  58. Hoch AL, Barker RW, Hair JA (1971) Measurement of physical parameters to determine suitability of modified woodlots as lone star tick habitat. J Med Entomol 8:725–730.PubMedGoogle Scholar
  59. Hoogstral H (1981) Changing patterns of tickborne disease in modern society. Ann Rev Entomol 26:75–99.CrossRefGoogle Scholar
  60. Hooker WA, Bishopp FC, Wood HP (1912) Some North American ticks. US Bureau Entomol Bull 106:1–204.Google Scholar
  61. Hopla CE (1955) The multiplication of tularemia organisms in the lone star tick. Am J Hyg 61:371–380.PubMedGoogle Scholar
  62. Hopla CE, Downs CM (1953) The isolation of Bacterium tularense from the tick Amblyomma americanum. J Kansas Entomol Soc 26:71–72.Google Scholar
  63. IJdo JW, Wu C, Magnarelli LA, Stafford KC, Anderson JF, Fikrig E (2000) Detection ofEhrlichia chaffeensis DNA inAmblyomma americanum ticks in Connecticut and Rhode Island. J Clin Microbiol 38:4655–4656.PubMedGoogle Scholar
  64. Iker S (1983) Swamped with deer. Natl Wildl 21:4–11.Google Scholar
  65. James AM, Liveris D, Wormser GP, Schwartz I, Montecalvo MA, Johnson BJ (2001)Borrelia lonestari infection after a bite by anAmblyomma americanum tick. J Infect Dis 183:1810–1814.PubMedCrossRefGoogle Scholar
  66. Keirans JE, Lacombe EH (1998) First records ofAmblyomma americanum Ixodes (Ixodes)dentatus, andIxodes (Ceratixodes)uriae (Acari: Ixodidae) from Maine. J Parasitol 84:629–631.PubMedCrossRefGoogle Scholar
  67. Kennamer JE, Kennamer M, Brenneman R (1992) History. In: Dickson JG (ed) The wild turkey: biology and management. Stackpole Books, Mechanicsburg, PA, pp 6–17.Google Scholar
  68. Kirkland KB, Klimko TB, Meriwether RA, Schriefer M, Levin M, Levine J, MacKenzie WR, Dennis DT (1997) Erythema migrans-like rash illness at a camp in North Carolina: a new tick-borne disease? Arch Intern Med 157:2635–2641.PubMedCrossRefGoogle Scholar
  69. Kocan AA, Levesque GC, Whitworth LC, Murphy GL, Ewing SA, Barker RW (2000) Naturally occurringEhrlichia chaffeensis infection in coyotes from Oklahoma. Emerging Infect Dis 6:477–480.PubMedCrossRefGoogle Scholar
  70. Kokernot RH, Calisher CH, Stannard LJ, Hayes J (1969) Arbovirus studies in the Ohio-Mississippi Basin, 1964–67. Lone star virus, a hitherto unknown agent isolated from the tickAmblyomma americanum (Linn.). Am J Trop Med Hyg 18:789–795.PubMedGoogle Scholar
  71. Kollars TM, Oliver JH, Durden LA, Kollars PG (2000) Host associations and seasonal activity ofAmblyomma americanum in Misssouri. J Parasitol 86:1156–1159.PubMedGoogle Scholar
  72. Krafsur ES, Whitten CJ, Novy JE (1987) Screwworm eradication in North and Central America. Parasitol Today 3:131–137.PubMedCrossRefGoogle Scholar
  73. Lacombe E, Rand PW, Smith RP (1993) Disparity ofBorrelia burgdorferi infection rates of adultIxodes dammini on deer and vegetation. J Infect Dis 167:1236–1238.PubMedGoogle Scholar
  74. Leopold A, Sowls LK, Spencer DL (1947) A survey of over-populated deer ranges in the United States. J Wildl Mangement 11:162–177.CrossRefGoogle Scholar
  75. Liddell AM, Stockham SL, Scott MA, Sumner JW, Paddock CD, Gaudreault-Keener M, Arens MQ, Storch GA (2003) Predominance ofEhrlichia ewingii in Missouri dogs. J Clin Microbiol 41:4617–4622.PubMedCrossRefGoogle Scholar
  76. Lockhart JM, Davidson WR, Dawson JE, Stallknecht DE (1995) Temporal association ofAmblyomma americanum with the presence ofEhrlichia chaffeensis-reactive antibodies in white-tailed deer. J Wildl Dis 31:119–124.PubMedGoogle Scholar
  77. Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE (1996) Site-specific geographic association betweenAmblyomma americanum (Acari: Ixodidae) infestations andEhrlichia chaffeensis-reactive (Rickettsiales: Ehrlichieae) antibodies in white-tailed deer. J Med Entomol 33:153–158.PubMedGoogle Scholar
  78. Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE, Howerth EW (1997a) Isolation ofEhlichia chaffeensis from wild white-tailed deer (Odocoileus virginianus) confirms their role as natural reservoir hosts. J Clin Microbiol 35:1681–1686.PubMedGoogle Scholar
  79. Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE, Little SE (1997b) Natural history ofEhrlichia chaffeensis (Rickettsiales: Ehrlichieae) in the Piedmont physiographic province of Georgia. J Parasitol 83:887–894.PubMedCrossRefGoogle Scholar
  80. Loftis AD, Reeves WK, Spurlock JP, Mahan SM, Troughton DR, Dasch GA, Levin ML (2006) Infection of a goat with a tick-transmitted Ehrlichia from Georgia, U.S.A., that is closely related to Ehrlichia ruminantium. J Vector Ecol 31:213–223.PubMedCrossRefGoogle Scholar
  81. Loken KI, Wu CC, Johnson RC, Bey RF (1985) Isolation of the Lyme disease spirochete from mammals in Minnesota. Proc Soc Exp Biol Med 179:300–302.PubMedGoogle Scholar
  82. Long SW, Zhang X, Zhang J, Ruble RP, Teel P, Yu XJ (2003) Evaluation of transovarial transmission and transmissibility ofEhrlichia chaffeensis (Rickettsiales: Anaplasmataceae) inAmblyomma americanum (Acari: Ixodidae). J Med Entomol 40:1000–1004.PubMedCrossRefGoogle Scholar
  83. Long SW, Pound JM, Yu XJ (2004)Ehrlichia prevalence inAmblyomma americanum, central Texas. Emerging Infect Dis 10:1342–1343.PubMedGoogle Scholar
  84. Maeda K, Markowitz N, Hawley RC, Ristic M, Cox D, McDade JE (1987) Human infection withEhrlichia canis, a leukocytic rickettsia. N Engl J Med 316:853–856.PubMedGoogle Scholar
  85. Machado RZ, Duarte JM, Dagnone AS, Szabo MP (2006) Detection ofEhrlichia chaffeensis in Brazilian marsh deer (Blatocercus dichotomus). Vet Parasitol 139:262–266.PubMedCrossRefGoogle Scholar
  86. Marshall WF, Telford SR, Rys RN, Rutledge BJ, Mathiesen D, Malawista SE, Spielman A, Persing DH (1994) Detection of Borrelia burgdorferi DNA in museum specimens of Peromyscus leucopus. J Infect Dis 170:1027–1032.PubMedGoogle Scholar
  87. Masters EJ, Donnell HD, Fobbs M (1994) Missouri Lyme disease: 1989–1992. J Spirochetal Tick-Borne Dis 1:12–17.Google Scholar
  88. Masters EJ, Granter S, Duray P, Cordes P (1998) Physician-diagnosed erythema migrans and erythema migrans-like rashes following lone star tick bites. Arch Dermatol 134:955–960.PubMedCrossRefGoogle Scholar
  89. McCabe RE, McCabe TR (1984) Of slings and arrows: an historical perspective. In: Halls LK (ed) White-tailed deer ecology and management. Stackpole Books, Harrisburg, PA, pp 19–72.Google Scholar
  90. McCullough DR (1984) Lesson from the George Reserve Michigan. In: Halls LK (ed) White-tailed deer ecology and management. Stackpole Books, Harrisburg, PA, pp 211–242.Google Scholar
  91. McDonald JS, Miller KV (1993) A history of white-tailed deer restocking in the United States 1878 to 1992. Research Publication 93–1, The Quality Deer Management Association, Watkinsville, GA.Google Scholar
  92. McQuiston JH, Paddock CD, Holman RC, Childs JE (1999) The human ehrlichioses in the United States. Emerging Infect Dis 5:635–642.PubMedCrossRefGoogle Scholar
  93. Means RG, White DJ (1997) New distribution records ofAmblyomma americanum (L) (Acari: Ixodidae) in New York State. J Vector Ecol 22:133–145.PubMedGoogle Scholar
  94. Merten HA, Durden LA (2000) A state-by-state survey of ticks recorded from humans in the United States. J Vector Ecol 25:102–113.PubMedGoogle Scholar
  95. Mixson TR, Ginsberg HS, Campbell SR, Sumner JW, Paddock CD (2004) Detection ofEhrlichia chaffeensis in adult and nymphalAmblyomma americanum (Acari: Ixodidae) ticks from Long Island, New York. J Med Entomol 41:1104–1110.PubMedCrossRefGoogle Scholar
  96. Mixson TR, Campbell SR, Gill JS, Ginsberg HS, Reichard MV, Schulze TL, Dasch GA (2006) Prevalence ofEhrlichia,Borrelia, and rickettsial agents inAmblyomma americanum (Acari: Ixodidae) collected from nine states. J Med Entomol 43:1261–1268.PubMedCrossRefGoogle Scholar
  97. Mock DE, Applegate RD, Fox LB (2001) Preliminary survey of ticks (Acari: Ixodidae) parasitizing wild turkeys (Aves: Phasianidae) in eastern Kansas. J Med Entomol 38:118–121.PubMedCrossRefGoogle Scholar
  98. Moore VA, Varela AS, Yabsley MJ, Davidson WR, Little SE (2003) Detection ofBorrelia lonestari, putative vector of southern tick-associated rash illness, in white-tailed deer (Odocoileus virginianus) from the southeatern United States. J Clin Microbiol 41:424–427.PubMedCrossRefGoogle Scholar
  99. Mount GA, Haile DG, Barnard DR, Daniels E (1993) New version of LSTSIM for computer simulation ofAmblyomma americanum (Acari: Ixodidae) population dynamics. J Med Entomol 30:843–857.PubMedGoogle Scholar
  100. Moyer P (2005) Experimental animal inoculations withBorrelia lonestari, putative agent of southern tick-associated rash illness. MS thesis. University of Georgia, Athens, GA.Google Scholar
  101. Moyer PL, Varela AS, Luttrell MP, Moore VA, Stallknecht DE, Little SE (2006) White-tailed deer (Odocoileus virginianus) develop spirochetemia following experimental infection with Borrelia lonestari. Vet Microbiol 115:229–236.PubMedCrossRefGoogle Scholar
  102. Mueller-Anneling L, Gilchrist MJ, Thorne PS (2000)Ehrlichia chaffeensis antibodies in white-tailed deer Iowa, 1994 and 1996. Emerging Infect Dis 6:397–400.PubMedCrossRefGoogle Scholar
  103. Ndip LM, Ndip RN, Esemu SN, Dickmu VL, Fokam EB, Walker DH, McBride JE (2005) Ehrlichial infection in Cameroonian canines by Ehrlichia canis and Ehrlichia ewingii. Vet Parasitol 111:59–66.Google Scholar
  104. Olano JP, Masters E, Hogrefe W, Walker DH (2003) Human monocytotropic ehrlichiosis Missouri. Emerging Infect Dis 9:1579–1586.PubMedGoogle Scholar
  105. Oliver JH, Stallknecht D, Chandler FH, James AM, McGuire BS, Howerth E (1992) Detection ofBorrelia burgdorferi in laboratory-rearedIxodes dammini (Acari: Ixodidae) fed on experimentally inoculated white-tailed deer. J Med Entomol 29:980–984.PubMedGoogle Scholar
  106. Oliver JH, Chandler FW, Luttrell MP, James AM, Stallknecht DE, McGuire BS, Hutcheson HJ, Cummins GA, Lane RS (1993) Isolation and transmission of the Lyme disease spirochete from the southeastern United States. Proc Natl Acad Sci U S A 90:7371–7375.PubMedCrossRefGoogle Scholar
  107. Paddock CD, Childs JE (2003)Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin Microbiol Rev 16:37–64.PubMedCrossRefGoogle Scholar
  108. Paddock CD, Folk SM, Shore GM, Machado LJ, Huycke MM, Slater LN, Liddell AM, Buller RS, Storch GA, Monson TP, Rimland D, Sumner JW, Singleton J, Bloch KC, Tang Y, Standaert SM, Childs JE (2001) Infections withEhrlichia chaffeensis andEhrlichia ewingii in persons coinfected with human immunodeficiency virus. Clin Infect Dis 33:1586–1594.PubMedCrossRefGoogle Scholar
  109. Paddock CD, Liddell AM, Storch GA (2005) Other causes of tick-borne ehrlichioses, including Ehrlichia ewingii. In: Goodman JL, Dennis DT, Sonenshine DE (eds) Tick-borne diseases of humans. ASM Press, Washington, DC, pp 258–267.Google Scholar
  110. Parker RR, Kohls GM (1943) American Q fever: the occurrence ofRickettsia diaporica inAmblyomma americanum in eastern Texas. Publ Health Rep 58:1510–1511.Google Scholar
  111. Patrick CD, Hair JA (1978) White-tailed deer utilization of different habitats and its influence on lone star tick populations. J Parasitol 64:1100–1106.CrossRefGoogle Scholar
  112. Persing DH, Telford SR, Rys PN, Dodge DE, White TJ, Malawista SE, Spielman A (1990) Detection ofBorrelia burgdorferi DNA in museum specimens ofIxodes dammini ticks. Science 249:1420–1423.PubMedCrossRefGoogle Scholar
  113. Philip CB, White JS (1955) Disease agents recovered incidental to a tick survey of the Mississippi Gulf Coast. J Econ Entomol 48:396–400.Google Scholar
  114. Piesman J, Spielman A (1982)Babesia microti: infectivity of parasites from ticks for hamsters and white-footed mice. Exp Parasitol 53:242–248.PubMedCrossRefGoogle Scholar
  115. Piesman J, Spielman A, Etkind P, Ruebush TK, Juranek DD (1979) Role of deer in the epizootiology ofBabesia microti in Massachusetts USA. J Med Entomol 15:537–540.PubMedGoogle Scholar
  116. Roland WE, Everett ED, Cyr TL, Hasan SZ, Dommaraju CB, McDonald GA (1998)Ehrlichia chaffeensis in Missouri ticks. Am J Trop Med Hyg 59:641–643.PubMedGoogle Scholar
  117. Rue LR (1978) The deer of North America. Crown Publishers, New York.Google Scholar
  118. Satalowich FT (1997) Tick-borne disease summary: 1996. Missouri Epidemiol 10–12.Google Scholar
  119. Schulze TL, Bowen GS, Bosler EM, Lakat MF, Parkin WE, Altman R, Ormiston BG, Shisler JK (1984)Amblyomma americanum: a potential vector of Lyme disease in New Jersey. Science 224:601–603.PubMedCrossRefGoogle Scholar
  120. Schulze TL, Jordan RA, Schultze CJ, Mixson T, Papero M (2005) Relative encounter frequencies and prevalence of selectedBorrelia Ehrlichia, andAnaplasma infections inAmblyomma americanum andIxodes scapularis (Acari: Ixodidae) ticks from central New Jersey. J Med Entomol 42:450–456.PubMedCrossRefGoogle Scholar
  121. Schulze TL, Jordan RA, Healy SP, Roegner VE, Meddis M, Jahn MB, Guthrie DL (2006) Relative abundance and prevalence of selectedBorrelia infections inIxodes scapularis andAmblyomma americanum (Acari: Ixodidae) from publicly owned lands in Monmouth County, New Jersey. J Med Entomol 43: 1269–1275.PubMedCrossRefGoogle Scholar
  122. Scrimenti RJ (1970) Erythema chronicum migrans. Arch Dermatol 102:104–105.PubMedCrossRefGoogle Scholar
  123. Severinghaus CW, Brown CP (1956) History of the white-tailed deer in New York. N Y Fish Game J 3:129–166.Google Scholar
  124. Sirigireddy KR, Mock DC, Ganta RR (2006) Multiplex detection of Ehrlichia and Anaplasma pathogens in vertebrate and tick hosts by real-time RT-PCR. Ann N Y Acad Sci 1078: 552–556.PubMedCrossRefGoogle Scholar
  125. Spielman A (1994) The emergence of Lyme disease and human babesiosis in a changing environment. Ann N Y Acad Sci 740:146–156.PubMedCrossRefGoogle Scholar
  126. Spielman A, Telford SR, Pollack RJ (1993) The origins and course of the present outbreak of Lyme disease. In: Ginsberg HS (ed) Ecology and environmental management of Lyme disease. Rutgers University Press, New Brunswick, NJ, pp 83–96.Google Scholar
  127. Steere AC, Broderick TF, Malawista SE (1978) Erythema chronicum migrans and Lyme arthritis: epidemiologic evidence for a tick vector. Am J Epidemiol 108:312–321.PubMedGoogle Scholar
  128. Steiert JG, Gilfoy F (2002) Infection rates ofAmblyomma americanum andDermacentor variabilis byEhrlichia chaffeensis andEhrlichia ewingii in southwest Missouri. Vector Borne Zoonotic Dis 2:53–60.PubMedCrossRefGoogle Scholar
  129. Stromdahl EY, Williamson PC, Kollars TM, Evans SR, Barry RK, Vince MA, Dobbs NA (2003) Evidence ofBorrelia lonestari DNA inAmblyomma americanum (Acari: Ixodidae) removed from humans. J Clin Microbiol 41:5557–5562.PubMedCrossRefGoogle Scholar
  130. Sumner JW, McKechnie D, Janowski D, Paddock CD (2000) Detection of Ehrlichia ewingii in field-collected ticks by using PCR amplification of 16S rRNA gene and groESL operon sequences. 15th Meeting of the American Society for Rickettsiology. Captiva Island, FL Abstract 72.Google Scholar
  131. Taft SC, Miller MK, Wright SM (2005) Distribution of borreliae among ticks collected from eastern states. Vector-Borne Zoonotic Dis 5:383–389.PubMedCrossRefGoogle Scholar
  132. Tate CM, Mead DG, Luttrell MP, Howerth EW, Dugan VG, Munderloh UG, Davidson WR (2005) Experiemental infection of white-tailed deer withAnaplasma phagocytophilum, the etiologic agent of human granulocytic anaplasmosis. J Clin Microbiol 43:3595–3601.PubMedCrossRefGoogle Scholar
  133. Telford SR, Mather TN, Moore SI, Wilson ML, Spielman A (1988) Incompetence of deer as reservoirs of the Lyme disease spirochete. Am J Trop Med Hyg 39:105–109.PubMedGoogle Scholar
  134. Telford SR, Dawson JE, Katavolos P, Warner CK, Kolbert CP, Persing DH (1996) Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proc Natl Acad Sci U S A 93:6209–6214.PubMedCrossRefGoogle Scholar
  135. Thomson BF (1977) The changing face of New England. Houghton Mifflin, Boston.Google Scholar
  136. Thompson C, Spielman A, Krause PJ (2001) Coinfecting deer-associated zoonoses: Lyme disease, babesiosis, and ehrlichiosis. Clin Infect Dis 33:676–685.PubMedCrossRefGoogle Scholar
  137. Varela AS, Luttrell MP, Howerth EW, Moore VA, Davidson WR, Stallknecht DE, Little SE (2004a) First culture isolation ofBorrelia lonestari, putative agent of southern tick-associated rash illness. J Clin Microbiol 42:1163–1169.PubMedCrossRefGoogle Scholar
  138. Varela AS, Moore VA, Little SE (2004b) Disease agents inAmblyomma americanum from northeastern Georgia. J Med Entomol 41:753–759.PubMedCrossRefGoogle Scholar
  139. Varela AS, Stallknecht DE, Yabsley MJ, Moore VA, Howerth EW, Davidson WR, Little SE (2005) Primary and secondary infection withEhrlichia chaffeensis in white-tailed deer (Odocoileus virginianus). Vector Borne Zoonotic Dis 5:48–57.PubMedCrossRefGoogle Scholar
  140. Varela-Stokes AS, Stokes JV, Davidson WR, Little SE (2006) Co-infection of white-tailed deer with multiple strains of Ehrlichia chaffeensis. Vector Borne Zoonotic Dis 6:140–151.PubMedCrossRefGoogle Scholar
  141. Vessel MF, Wong HH (1987) Natural history of vacant lots. University of California Press, Berkeley.Google Scholar
  142. Wahlenberg WG (1946) Longleaf pine, its use, ecology, regeneration, protection, growth and management. Charles Lathrop Pack Forestry Foundation, Washington, DC.Google Scholar
  143. Western KA, Benson GD, Gleason NN, Healy GR, Schultz MG (1970) Babesiosis in a Massachusetts resident. N Engl J Med 283:854–856.PubMedCrossRefGoogle Scholar
  144. Whitaker JO, Hamilton WJ (1998) Mammals of the eastern United States, 3rd edn. Cornell University Press, Ithaca NY.Google Scholar
  145. Whitlock JE, Fang QQ, Durden LA, Oliver JH (2000) Prevalence ofEhrlichia chaffeensis (Rickettsiales: Rickettsiaceae) inAmblyomma americanum (Acari: Ixodidae) from the Georgia coast and barrier islands. J Med Entomol 37:276–280.PubMedCrossRefGoogle Scholar
  146. Wilson ML, Alder GH, Spielman A (1985) Correlation between abundance of deer and that of the deer tickIxodes dammini (Acari: Ixodidae). Ann Entomol Soc Am 78:172–176.Google Scholar
  147. Wolf L, McPherson T, Harrison B, Engber B, Anderson A, Whitt P (2000) Prevalence ofEhrlichia ewingii inAmblyomma americanum in North Carolina. J Clin Microbiol 38:2795.PubMedGoogle Scholar
  148. Wormser GP, Masters E, Liveris D, Nowakowski J, Nadelman RB, Holmgren D, Bittker S, Cooper D, Wang G, Schwartz I (2005) Microbiologic evaluation of patients from Missouri with erythema migrans. Clin Infect Dis 40:423–428.PubMedCrossRefGoogle Scholar
  149. Yabsley MJ, Varela AS, Tate CM, Dugan VG, Stallknecht DE, Little SE, Davidson WR (2002)Ehrlichia ewingii infection in white-tailed deer (Odocoileus virginianus). Emerging Infect Dis 8:668–671.PubMedGoogle Scholar
  150. Yabsley MJ, Dugan VG, Stallknecht DE, Little SE, Lockhart JM, Dawson JE, Davidson WR (2003a) Evaluation of a prototypeEhrlichia chaffeensis surveillance system using white-tailed deer (Odocoileus virginianus) as natural sentinels. Vector Borne Zoonotic Dis 3:195–207.PubMedCrossRefGoogle Scholar
  151. Yabsley MJ, Little SE, Sims EJ, Dugan VJ, Stallknecht DE, Davidson WR (2003b) Molecular variation in the variable-length PCR target and 120-kDa antigen genes ofEhrlichia chaffeensis from white-tailed deer (Odocoileus virginianus). J Clin Microbiol 41:5202–5206.PubMedCrossRefGoogle Scholar
  152. Yabsley MJ, Norton TM, Powell MR, Davidson WR (2004) Molecular and serologic evidence of tick-borne ehrlichiae in three species of lemurs from St. Catherines Island, Georgia USA. J Zoo Wildl Med 35:503–509.PubMedCrossRefGoogle Scholar
  153. Yabsley MJ, Wimberly MC, Stallknecht DE, Little SE, Davidson WR (2005) Spatial analysis of the distribution ofEhrlichia chaffeensis, causative agent of human monocytotropic ehrlichiosis, across a multi-state region. Am J Trop Med Hyg 72:840–850.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • C. D. Paddock
    • 1
  • M. J. Yabsley
    • 2
  1. 1.Division of Viral and Rickettsial DiseasesNational Center for Infectious Diseases, Centers for Disease Control and PreventionAtlantaUSA
  2. 2.Southeastern Cooperative Wildlife Disease Study, College of Veterinary MedicineUniversity of GeorgiaAthensUSA

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