Advertisement

Endoscopic Mucosal Resection for Staging and Therapy of Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third

  • Henriette HeinrichEmail author
  • Peter Bauerfeind
Chapter
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 182)

Abstract

Minamally invasive endoscopic resection techniques allow definitive histological staging for dysplasia and early cancer and in many cases curative treatment. In Barrett’s esophagus with High Grade Dysplasia (HGD) or early mucosal cancer, endoscopic mucosal resection (EMR) should be considered both as diagnostic and therapeutic first line procedure, with the possibility to repeat the procedure in case of residual Barrett’s dysplasia or mucosal cancer. In early cancer of the the submucosa, surgical resection should be discussed. Endoscopic submucosal dissection (ESD) is a useful therapeutic option for HGD or early cancer in the squamous epithelium of the esophagus or in the stomach when en bloc resection is needed in large lesions.

Keywords

Endoscopic Submucosal Dissection Early Gastric Cancer Endoscopic Resection Endoscopic Mucosal Resection Bloc Resection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Abe N et al (2002) Risk factors predictive of lymph node metastasis in depressed early gastric cancer. Am J Surg 183(2):168–172PubMedCrossRefGoogle Scholar
  2. Chung IK et al (2009) Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms: Korean ESD Study Group multicenter study. Gastrointest Endosc 69(7):1228–1235PubMedCrossRefGoogle Scholar
  3. Coda S et al (2009) Risk factors for cardiac and pyloric stenosis after endoscopic submucosal dissection, and efficacy of endoscopic balloon dilation treatment. Endoscopy 41(5):421–426PubMedCrossRefGoogle Scholar
  4. Curvers WL et al (2008) Endoscopic tri-modal imaging for detection of early neoplasia in Barrett’s oesophagus: a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. Gut 57(2):167–172PubMedCrossRefGoogle Scholar
  5. Fujishiro M et al (2006) Endoscopic submucosal dissection of esophageal squamous cell neoplasms. Clin Gastroenterol Hepatol 4(6):688–694PubMedCrossRefGoogle Scholar
  6. Ginsberg GG (2008) Endoscopic approaches to Barrett’s oesophagus with high-grade dysplasia/early mucosal cancer. Best Pract Res Clin Gastroenterol 22(4):751–772PubMedCrossRefGoogle Scholar
  7. Giovannini M et al (2004) Circumferential endoscopic mucosal resection in Barrett’s esophagus with high-grade intraepithelial neoplasia or mucosal cancer. Preliminary results in 21 patients. Endoscopy 36(9):782–787Google Scholar
  8. Gondrie JJ et al (2008) Stepwise circumferential and focal ablation of Barrett’s esophagus with high-grade dysplasia: results of the first prospective series of 11 patients. Endoscopy 40(5):359–369PubMedCrossRefGoogle Scholar
  9. Goto O et al (2009) Outcomes of endoscopic submucosal dissection for early gastric cancer with special reference to validation for curability ­criteria. Endoscopy 41(2):118–122PubMedCrossRefGoogle Scholar
  10. Gotoda T (2008) Endoscopic resection for premalignant and malignant lesions of the gastrointestinal tract from the esophagus to the colon. Gastrointest Endosc Clin North Am 18(3):435–450CrossRefGoogle Scholar
  11. Green S et al (2009) Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett’s oesophagus. Cochrane Database Syst Rev 2: CD007334Google Scholar
  12. Holt AP, Patel M, Ahmed MM (2004) Palliation of patients with malignant gastroduodenal obstruction with self-expanding metallic stents: the treatment of choice? Gastrointest Endosc 60(6):1010–1017PubMedCrossRefGoogle Scholar
  13. Hull MJ et al (2006) Endoscopic mucosal resection: an improved diagnostic procedure for early gastroesophageal epithelial neoplasms. Am J Surg Pathol 30(1):114–118PubMedCrossRefGoogle Scholar
  14. Inoue H, Endo M (1990) Endoscopic esophageal mucosal resection using a transparent tube. Surg Endosc 4(4):198–201PubMedCrossRefGoogle Scholar
  15. Ishihara R et al (2008) Local recurrence of large squamous-cell carcinoma of the esophagus after endoscopic resection. Gastrointest Endosc 67(6):799–804PubMedCrossRefGoogle Scholar
  16. Kato H et al (2001) Lifting of lesions during endoscopic mucosal resection (EMR) of early colorectal cancer: implications for the assessment of resectability. Endoscopy 33(7):568–573PubMedCrossRefGoogle Scholar
  17. Larghi A, Waxman I (2007) State of the art on endoscopic mucosal resection and endoscopic submucosal dissection. Gastrointest Endosc Clin North Am 17(3):441–469CrossRefGoogle Scholar
  18. Larghi A et al (2007) Long-term follow-up of complete Barrett’s eradication endoscopic mucosal resection (CBE-EMR) for the treatment of high grade dysplasia and intramucosal carcinoma. Endoscopy 39(12):1086–1091PubMedCrossRefGoogle Scholar
  19. May A et al (2002a) Local endoscopic therapy for intraepithelial high-grade neoplasia and early adenocarcinoma in Barrett’s oesophagus: acute-phase and intermediate results of a new treatment approach. Eur J Gastroenterol Hepatol 14(10):1085–1091PubMedCrossRefGoogle Scholar
  20. May A et al (2002b) Intraepithelial high-grade neoplasia and early adenocarcinoma in short-­segment Barrett’s esophagus (SSBE): curative treatment using local endoscopic treatment techniques. Endoscopy 34(8):604–610PubMedCrossRefGoogle Scholar
  21. Miyamoto S et al (2002) A new technique for endoscopic mucosal resection with an insulated-tip electrosurgical knife improves the completeness of resection of intramucosal gastric neoplasms. Gastrointest Endosc 55(4):576–581PubMedCrossRefGoogle Scholar
  22. Odze RD, Lauwers GY (2008) Histopathology of Barrett’s esophagus after ablation and endoscopic mucosal resection therapy. Endoscopy 40(12): 1008–1015PubMedCrossRefGoogle Scholar
  23. Ono H (2006) Early gastric cancer: diagnosis, pathology, treatment techniques and treatment outcomes. Eur J Gastroenterol Hepatol 18(8):863–866PubMedCrossRefGoogle Scholar
  24. Pech O et al (2008) Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus. Gut 57(9):1200–1206PubMedCrossRefGoogle Scholar
  25. Peters FP et al (2006) Stepwise radical endoscopic resection is effective for complete removal of Barrett’s esophagus with early neoplasia: a prospective study. Am J Gastroenterol 101(7):1449–1457PubMedCrossRefGoogle Scholar
  26. Pohl J et al (2008) Endoscopic resection of early esophageal and gastric neoplasias. Dig Dis 26(4):285–290PubMedCrossRefGoogle Scholar
  27. Pouw RE, Bergman JJ (2008) Endoscopic resection of early oesophageal and gastric neoplasia. Best Pract Res Clin Gastroenterol 22(5):929–943PubMedCrossRefGoogle Scholar
  28. Rastogi A et al (2008) Incidence of esophageal adenocarcinoma in patients with Barrett’s esophagus and high-grade dysplasia: a meta-analysis. Gastrointest Endosc 67(3):394–398PubMedCrossRefGoogle Scholar
  29. Rosch T et al (2004) Attempted endoscopic en bloc resection of mucosal and submucosal tumors using insulated-tip knives: a pilot series. Endo­scopy 36(9):788–801PubMedCrossRefGoogle Scholar
  30. Saito Y et al (2008) Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection. Dig Dis Sci 53(2):330–333PubMedCrossRefGoogle Scholar
  31. Seewald S et al (2003) Circumferential EMR and complete removal of Barrett’s epithelium: a new approach to management of Barrett’s esophagus containing high-grade intraepithelial neoplasia and intramucosal carcinoma. Gastrointest Endosc 57(7):854–859PubMedCrossRefGoogle Scholar
  32. Shaheen NJ et al (2009) Radiofrequency ablation in Barrett’s esophagus with dysplasia. N Engl J Med 360(22):2277–2288PubMedCrossRefGoogle Scholar
  33. Siddiqui J, Gerke H (2008) Efficacy and safety of band ligator assisted mucosal resection to completely remove Barrett’s esophagus with high grade dysplasia or early cancer. Gastrointest Endosc 67(5): AB177–AB177Google Scholar
  34. Soehendra N et al (2006) Use of modified multiband ligator facilitates circumferential EMR in Barrett’s esophagus (with video). Gastrointest Endosc 63(6):847–852PubMedCrossRefGoogle Scholar
  35. Uedo N et al (2006) Longterm outcomes after endoscopic mucosal resection for early gastric cancer. Gastric Cancer 9(2):88–92PubMedCrossRefGoogle Scholar
  36. van der Burgh A et al (1996) Oesophageal cancer is an uncommon cause of death in patients with Barrett’s oesophagus. Gut 39(1):5–8PubMedCrossRefGoogle Scholar
  37. von Rahden BHA, Feith M, Stein HJ (2006) [Limited Surgical Resection Versus Local Endoscopic Therapy of Early Cancers of the Esophagogastric Junction]. Zentralbl Chir 131(2):97–104Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of Hepatology and GastroenterologyUniversity of ZüerichZüerichSwitzerland

Personalised recommendations