Differences in the Molecular Biology of Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third

  • Kuno Lehmann
  • Paul M. SchneiderEmail author
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 182)


Adenocarcinoma of the distal esophagus, gastric cardia, and upper gastric third are grouped in type I-III by the Siewert classification. This classification is based on the endoscopic localisation of the tumor center, and is the most important diagnostic tool to group these tumors. On a molecular level, there is currently no marker that would allow to differentiate the three different types. Furthermore, the Siewert classification was not uniformly used in the recent literature, making interpretation and generalization of these results difficult. However, several potential targets have been identified that may help to separate these tumors by molecular markers, and are summarized in this chapter.


Vascular Endothelial Growth Factor Esophageal Carcinoma Intestinal Metaplasia Gastric Cardia Cardia Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of SurgeryUniversity Hospital of ZurichZurichSwitzerland

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