Clinical Classification Systems of Adenocarcinoma of the Esophagogastric Junction

  • Stefan Paul MönigEmail author
  • Arnulf H. Hölscher
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 182)


The classification and definition of adenocarcinomas of the esophagogastric junction (EGJ) have not been standardized, and the choice of surgical procedures is still the subject of controversy. In contrast to the decreasing frequency of gastric cancer and squamous cell carcinomas of the esophagus, a number of studies from various western industrialized nations have reported an increased incidence of adenocarcinomas of the esophagus and cardia in the last 30 years. Studies from population-based cancer registries in the United States, the United Kingdom, and Switzerland have indicated a rapid increase in the incidence of adenocarcinoma of the EGJ (Devesa et al. 1998; Bollschweiler et al. 2001, 2002; Sharma et al. 2003). The reasons for this increase remain unclear; however, a number of causes are being discussed, such as the malignant potential of Barrett mucosa and etiologic factors, such as obesity, dietary factors, alcohol, pharmaceutical agents, and tobacco (Bollschweiler et al. 2001).


Esophageal Carcinoma Intestinal Metaplasia Esophagogastric Junction Cardiac Mucosa Western Industrialize Nation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of General, Visceral and Cancer SurgeryUniversity of CologneCologneGermany

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