Temporal Subtraction Versus Dual-Energy Contrast-Enhanced Digital Breast Tomosynthesis: A Pilot Study
In contrast-enhanced DBT (CE-DBT), breast lesion vascularity is characterized by administrating an iodinated vascular contrast agent. In this work, a combined temporal and dual-energy (DE) subtraction CE-DBT technique was performed in 4 women with mammographic findings that warranted biopsy. Lesion enhancement characteristics and morphology obtained with both CE-DBT techniques are correlated to lesion enhancement characteristics and morphology obtained with CE-MRI. The findings are compared to the clinical outcome of the regular DBT exam. Preliminary results show that both temporal and DE CE-DBT provide morphologic and qualitative vascular information concordant with CE-MRI. Temporal subtraction is the most sensitive method since background breast tissue can be completely canceled while with DE CE-DBT tissue background can only be partially canceled. However, the temporal CE-DBT image data suffer from significantly more motion artifacts and therefore possible misdiagnosis.
KeywordsContrast-Enhanced Digital Breast Tomosynthesis Dual Energy Subtraction Temporal Subtraction vascular contrast agent
Unable to display preview. Download preview PDF.
- 1.Weidner, N., Semple, J.P., Welch, W.R., Folkman, J.: Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. New England Journal of Medicine 324, 1–8 (1991)Google Scholar
- 3.Puong, S., Patoureaux, F., Iordache, R., Muller, S.: Dual-energy contrast enhanced digital breast tomosynthesis: concept, method, and evaluation on phantoms. In: Hsieh, J., Flynn, M.J. (eds.) Proc. Medical Imaging 2007: Physics of Medical Imaging, vol. 6510. SPIE, San Diego (2007)Google Scholar
- 4.Carton, A.K., Lindman, K., Ullberg, C.K., Francke, T.: Dual-energy subtraction for contrast enhanced digital breast tomosynthesis. In: Hsieh, J., Flynn, M.J. (eds.) Proc. Physics of Medical Imaging, vol. 6510. SPIE, San Diego (2007)Google Scholar
- 6.Schnall, M.D., Blume, J., Bluemke, D.A., DeAngelis, G.A., DeBruhl, N., Harms, S., Heywang-Köbrunner, S.H., Hylton, N.M., Kuhl, C.K., Pisano, E.D., Causer, P., Schnitt, S.J., Thickman, D., Stelling, C.B., Weatherall, P.T., Lehman, C., Gatsonis, C.A.: Diagnostic architectural and dynamic features at breast MR imaging: multicenter study. Radiology 238(1), 42–53 (2006)CrossRefGoogle Scholar