Auszug
Die photodynamische Therapie (PDT) am Auge wurde als neue Therapie der exsudativen Form der altersabhängigen Makuladegeneration (AMD) und bei choroidalen Neovaskularisationen (CNV) im Rahmen von pathologischer Myopie Ende der 90er Jahre eingeführt. Die Therapieempfehlungen basierten auf den Ergebnissen zweier großer prospektiver, multizentrischer, randomisierter klinischer Studien (TAP- und VIP-Studie) [1]–[3]. In der Zwischenzeit wurde die PDT am Auge auch bei zahlreichen anderen Pathologien mit zum Teil bemerkenswertem Erfolg angewendet [4, 5]. Im Folgenden werden wir auf die idiopathische choroidale Neovaskularisation im Speziellen eingehen und eine Literaturübersicht über bisherige publizierte Beiträge und eigene Ergebnisse in Form von Fallberichten präsentieren.
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Literatur
Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year result of 2 randomized clinical trials — TAP report. Arch Ophthalmol 117: 1329–1345
Verteporfin in Photodynamic Therapy Study Group (2001) Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year result of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization — verteporfin in photodynamic therapy report 2. Am J Ophthalmol 131: 541–560
Blinder KJ, Blumenkranz MS, Bressler NM, Bressler SB, Donato G, Lewis H, Lim JI, Menchini U, Miller JW, Mones JM, Potter MJ, Pournaras C, Reaves A, Rosenfeld P, Schachat AP, Schmidt-Erfurth U, Sickenberg M, Singerman LJ, Slakter JS, Strong HA, Virgili G, Williams GA (2003) Verteporfin therapy of subfoveal choroidal neovascularization in pathologic myopia: 2-year results of a randomized clinical trial. VIP report no. 3. Ophthalmology 110: 667–673
Mennel S, Barbazetto I, Meyer CH, Peter S, Stur M (2007) Ocular photodynamic therapy — standard applications and new indications. Part 2. Review of the literature and personal experience. Ophthalmologica 221: 282–291
Mennel S, Barbazetto I, Meyer CH, Peter S, Stur M (2007) Ocular photodynamic therapy — standard applications and new indications (part 1). Review of the literature and personal experience. Ophthalmologica 221: 216–226
Derosa JT, Yannuzzi LA, Marmor M, Fotino M, Sorenson JA, Spaide RF (1995/96) Risk factors for neovascularization in young patients: a case-control study. Doc Ophthalmol 91: 207–222
Spaide RF (1999) Choroidal neovascularization in younger patients. Curr Opin Ophthalmol 10: 177–181
Cohen SY, Laroche A, Leguen Y, Soubrane G, Coscas GJ (1996). Etiology of choroidal neovascularization in young patients. Ophthalmology 103: 1241–1244
Lindblom B, Andersson T (1998) The prognosis of idiopathic choroidal neovascularization in persons younger than 50 years of age. Ophthalmology 105: 1816–1820
Ho AC, Yannuzzi LA, Pisicano K, DeRosa J (1995) The natural history of idiopathic subfoveal choroidal neovascularization. Ophthalmology 102: 782–789
Mimouni KF, Bressler SB, Bressler NM (2003) Photodynamic therapy with verteporfin for subfoveal choroidal neovascularization in children. Am J Ophthalmol 135: 900–902
Harissi-Dagher M, Sebag M, Gauthier D, Marcil G, Labelle P, Arbour JD (2005) Photodynamic therapy in young patients with choroidal neovascularization following traumatic choroidal rupture. Am J Ophthalmol 139: 726–728
Giansanti F, Virgili G, Varano M, Tedeschi M, Rapizzi E, Giacomelli G, Menchini U (2005) Photodynamic therapy for choroidal neovascularization in pediatric patients. Retina 25: 590–596
Potter MJ, Szabo SM, Ho T (2006) Combined photodynamic therapy and intravitreal triamcinolone for the treatment of myopic choroidal neovascularization in a 13-year-old girl. Graefes Arch Clin Exp Ophthalmol 244: 639–641
Postelmans L, Pasteels B, Coquelet P, El Ouardighi H, Verougstraete C, Schmidt-Erfurth U (2004) Severe pigment epithelial alterations in the treatment area following photodynamic therapy for classic choroidal neovascularization in young females. Am J Ophthalmol 138: 803–808
Wachtlin J, Behme T, Heimann H, Kellner U, Foerster MH (2003) Concentric retinal pigment epithelium atrophy after a single photodynamic therapy. Graefes Arch Clin Exp Ophthalmol 241: 518–521
Sii F, Lee LR (2006) Retinopathy associated with photodynamic therapy for treatment of idiopathic choroidal neovascularization. Clin Experiment Ophthalmol 34: 184–186
Mennel S, Peter S, Meyer CH, Thuman G (2006) Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model. Graefes Arch Clin Exp Ophthalmol 244: 1015–1021
Höh H, Marzelin S, Methlin D (2004) Individualisierung der Behandlungsparameter der PDT. Klin Monatsbl Augenheilkund 221(Suppl 4): 10
Sickenberg M, Schmidt-Erfurth U, Miller JW, Pournaras CJ, Zografos L, Piguet B, Donati G, Laqua H, Barbazetto I, Gragoudas ES, Lane AM, Birngruber R, van den Bergh H, Strong HA, Manjuris U, Gray T, Fsadni M, Bressler NM (2000) A preliminary study of photodynamic therapy using verteporphin for choroidal neovascularisation in pathologic myopia, ocular histoplasmosis syndrome, angioid streaks, and idiopathic causes. Arch Ophthalmol 118: 327–336
Muller-Velten R, Michels S, Schmidt-Erfurth U, Laqua H (2003) Photodynamic therapy: extended indication. Ophthalmologe 100: 384–390
Spaide RF, Martin ML, Slakter J, Yannuzzi LA, Sorenson J, Guyer DR, Freund KB (2002) Treatment of idiopathic subfoveal choroidal neovascular lesions using photodynamic therapy with verteporfin. Am J Ophthalmol 134: 62–68
Chan WM, Lam DS, Wong TH, Lai TY, Kwok AK, Tam BS, Li KK (2003) Photodynamic therapy with verteporfin for subfoveal idiopathic choroidal neovascularization: oneyear results from a prospective case series. Ophthalmology 110: 2395–2402
Wachtlin J, Wehner A, Heimann H, Foerster MH (2004) Photodynamic treatment with verteporfin for patients with idiopathic choroidal neovascularization. Two-year results. Ophthalmologe 101: 489–495
Su ZA, Yao K, Shen J, Jiang JK, Fang XY, Lin JJ, DU XH (2007) Evaluation of photodynamic therapy in idiopathic choroidal neovascularization. Zhonghua Yan Ke Za Zhi 43: 509–513
Ruiz-Moreno JM, Montero JA, Arias L, Sanabria MR, Coco R, Silva R, Araiz J, Gomez-Ulla F, Garcia-Layana A (2006) Photodynamic therapy in subfoveal and juxtafoveal idiopathic and postinflammatory choroidal neovascularization. Acta Ophthalmol Scand 84: 743–748
Karacorlu M, Karacorlu S, Ozdemir H (2004) Photodynamic therapy in patients with idiopathic choroidal neovascularization. Jpn J Ophthalmol 48: 422–424
Lam A, Lee HC, Ho AC, Regillo CD, McNamara JA, Fineman MD (2006) Photodynamic therapy in young patients. Ophthalmic Surg Lasers Imaging 37: 182–189
Rogers AH, Duker JS, Nichols N, Baker BJ (2003) Photodynamic therapy of idiopathic and inflammatory choroidal neovascularization in young adults. Ophthalmology 110: 1315–1320
Yoo MH, Boo HD, Kim HK (2005) Result of photodynamic therapy for idiopathic subfoveal choroidal neovascularization. Korean J Ophthalmol 19: 264–268
Chan WM, Lai TY, Lau TT, Lee VY, Liu DT, Lam DS (2008) Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. Retina 28: 71–80
Giovannini A, Neri P, Mercanti L, Bruè C (2007) Photodynamic treatment versus photodynamic treatment associated with systemic steroids for idiopathic choroidal neovascularisation. Br J Ophthalmol 91: 620–623
Uemura A, Thomas MA (2000) Visual outcome after surgical removal of choroidal neovascularization in pediatric patients. Arch Ophthalmol 118: 1373–1378
Mennel S, Schmidt JC, Meyer CH (2003) Therapeutic strategies in choroidal neovascularizations secondary to angioid streaks. Am J Ophthalmol 136: 580–582
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Mennel, S., Meyer, C.H. (2008). Therapie der idiopathischen CNV mittels photodynamischer Therapie. In: Lang, G.E. (eds) Photodynamische Therapie in der Augenheilkunde — Verschiedene Indikationen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70506-2_2
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