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Cell Cycle Control pp 149–179Cite as

Regulation of the Cell Cycle by the Rb Tumor Suppressor Family

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 22))

Abstract

The rare childhood cancer retinoblastoma is caused, at least in part, by inactivating mutations in the retinoblastoma gene. The study of the retinoblastoma protein (Rb) over the past decade has led to a significant advance in our molecular understanding of many forms of cancer which take the lives of thousands of people (of all ages) every year. Deregulated cell proliferation is a common feature of many cancers. Rb, though not essential for cell proliferation, plays a significant role in regulating cell cycle progression and perturbation of Rb, or its upstream regulators appear to have an important role in the development of the majority of human solid tumors. This review will describe how Rb and two of its relatives, p107 and p130, are thought to regulate cell proliferation and differentiation, and what is known about how loss of Rb function might contribute to tumor formation.

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Authors and Affiliations

  1. The Dana-Farber Cancer Institute and the Harvard Medical School, 44 Binney Street, Boston, Massachusetts, 02115, USA

    M. E. Ewen

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  1. Department of Pathology, MSB 548, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA

    Michele Pagano

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© 1998 Springer-Verlag Berlin Heidelberg

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Ewen, M.E. (1998). Regulation of the Cell Cycle by the Rb Tumor Suppressor Family. In: Pagano, M. (eds) Cell Cycle Control. Results and Problems in Cell Differentiation, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69686-5_7

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  • DOI: https://doi.org/10.1007/978-3-540-69686-5_7

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