Suspected Epstein–Barr Virus (EBV) Disease of the Anterior Segment

  • Thomas Reinhard


• EBV specific antibodies (IgG) are found in the majority of healthy subjects and are therefore no direct evidence for presumed EBV etiology of eye disease.

• Since EBV DNA can also be found in healthy eyes, detection of its genome in eye fluids and tissues is not more than a hint at suspected EBV eye disease.

• Diagnosis of EBV caused eye disease is justified, if ocular symptoms and signs are observed in the acute phase of primary EBV disease together with EBV specific IgM antibodies.

• Diagnosis of recurrent EBV eye disease is far more equivocal. If in a case of “atypical herpes keratitis”, e. g., only EBV specific antibodies are found and no antibodies against herpes simplex virus (HSV), varicella zoster virus (VZV), and cytomegaly virus (CMV), and if in addition a positive PCR proves the presence of EBV DNA in the disease area, then a causal role for EBV can be assumed with sufficient probability. Such a case is described.

• For therapy of deep recurrent EBV disease of the anterior segment of the eye, a combination of acyclovir (ACV) plus steroids is recommended.


Herpes Simplex Virus Barr Virus Infectious Mononucleosis Stromal Keratitis Virus Carrier State 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Thomas Reinhard
    • 1
  1. 1.University Eye HospitalFreiburgGermany

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