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Acute Tubulointerstitial Nephritis

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Management of Acute Kidney Problems

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Abstract

Acute tubulointerstitial nephritis (ATIN) is a cause of acute kidney injury (AKI) which is characterized by the presence of inflammatory cells within the renal tubules and interstitium. The etiology of ATIN is diverse but is most frequently associated to a drug reaction, infection, or autoimmune pathology. Diagnostic clues can be found from the patient’s history, examination, and laboratory investigation results, but a renal biopsy is recommended to confirm the diagnosis and facilitate early treatment. Drug-induced ATIN should be treated by stopping any causative agent and starting oral steroids. Infection-related and autoimmune ATIN should be managed by treating the underlying cause.

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Authors and Affiliations

  1. Department of Renal Medicine, St James’s University Hospital, Beckett Street, Leeds, LS9 7TF, UK

    Richard J. Baker

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  1. David J. Border
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  2. Richard J. Baker
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Correspondence to Richard J. Baker .

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Editors and Affiliations

  1. Charité Campus Virchow, Universitätsklinikum Berlin, Augustenburger Platz 1, Berlin, 13353, Germany

    Achim Jörres

  2. Dipto. Nefrologia, Ospedale San Bortolo, Viale Rodolfi 16, Vicenza, 36100, Italy

    Claudio Ronco

  3. School of Medicine, University of Pittsburgh, Terrace Street 3550, Pittsburgh, 15261, U.S.A.

    John A. Kellum

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Border, D.J., Baker, R.J. (2010). Acute Tubulointerstitial Nephritis. In: Jörres, A., Ronco, C., Kellum, J. (eds) Management of Acute Kidney Problems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69441-0_37

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  • DOI: https://doi.org/10.1007/978-3-540-69441-0_37

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