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Molekulare Mechanismen von Zell-Zell-Wechselwirkungen

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Grundlagen der Molekularen Medizin

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Molekulare Mechanismen für spezifische Wechselwirkungen zwischen Zellen entstanden schon früh in der Evolution, beim übergang von einzelligen zu vielzelligen Eukaryonten. Während der Embryonalentwicklung der Wirbeltiere spielen Zell-Zell-Wechselwirkungen in der Histogenese und Organogenese eine Rolle, im adulten Organismus stabilisieren sie das ausdifferenzierte Gewebe. Viele zelluläre Interaktionen in der Ontogenese sind überwiegend dynamisch, dagegen sind die meisten Zell-Zell-Wechselwirkungen im adulten Gewebe weitgehend statisch. Viele Zellen des Immunsystems gehen besonders dynamische, teilweise kurzlebige, zelluläre Interaktionen ein (Alberts et al. 1994; Karp 1999; Lodish et al. 2000; Wolpert et al. 1999).

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  1. Novartis Institutes for Biomedical Research, 4002, Basel, Schweiz

    Dr. Thomas Brümmendorf

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  1. Der Vorstandsvorsitzende (CEO), Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin

    Detlev Ganten

  2. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10, 13125, Berlin-Buch

    Klaus Ruckpaul

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Brümmendorf, T. (2008). Molekulare Mechanismen von Zell-Zell-Wechselwirkungen. In: Ganten, D., Ruckpaul, K. (eds) Grundlagen der Molekularen Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69414-4_2

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