Abstract
Two quaternary ammonium compounds, namely benzalkonium chloride and cetyl pyridinium chloride, have been studied as additives for incorporation into acrylic bone cement (Palacos K-40) as anti-microbial agents. Each compound was added at 1% and 5% by mass. Setting time of the cement was 9.75 minutes. This was not altered by benzalkonium chloride (5%), but was shortened to 9.00 minutes by 5% cetyl pyridinium chloride.
Release was determined by measuring chloride release from set cement specimens with a chloride-ion selective electrode. Release was shown to occur but it did not follow simple diffusion-based kinetics. Rather it was a complicated process, and similar to that of gentamicin sulphate from bone cements.
The results show that these anti-microbial compounds can be incorporated into acrylic bone cement and then released satisfactorily, suggesting that these compounds have the potential to be used as active ingredients in orthopaedic cements.
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Nicholson, J., Mathey, M., Surana, V. (2008). Release of Quaternary Ammonium Antimicrobial Compounds from Acrylic Bone Cement. In: Katashev, A., Dekhtyar, Y., Spigulis, J. (eds) 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics. IFMBE Proceedings, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69367-3_15
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DOI: https://doi.org/10.1007/978-3-540-69367-3_15
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